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Protein

Myogenic factor

Gene

Myf5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factorUniRule annotation
Gene namesi
Name:Myf5Imported
ORF Names:mCG_16983Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97252. Myf5.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000435.
ExpressionAtlasiA2RSK4. baseline and differential.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA2RSK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 134BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
HOVERGENiHBG006429.
KOiK18484.
OMAiSFDSVYC.
OrthoDBiEOG091G0GKD.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
PfamiView protein in Pfam
PF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
SMARTiView protein in SMART
SM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RSK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD
60 70 80 90 100
DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACAADKSS
210 220 230 240 250
VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP ATPGPSSSRL

IYHVL
Length:255
Mass (Da):28,229
Last modified:March 6, 2007 - v1
Checksum:i0BDCBEDF2ABCAEC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132144 mRNA. Translation: AAI32145.1.
CH466539 Genomic DNA. Translation: EDL21695.1.
RefSeqiNP_032682.1. NM_008656.5.
XP_006513382.1. XM_006513319.2.
UniGeneiMm.4984.

Genome annotation databases

GeneIDi17877.
KEGGimmu:17877.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA2RSK4_MOUSE
AccessioniPrimary (citable) accession number: A2RSK4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 5, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)