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A2RRU1

- GYS1_RAT

UniProt

A2RRU1 - GYS1_RAT

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Protein
Glycogen [starch] synthase, muscle
Gene
Gys1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan By similarity.

Catalytic activityi

UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391UDP-glucose By similarity

GO - Molecular functioni

  1. glucose binding Source: RGD
  2. glycogen (starch) synthase activity Source: RGD

GO - Biological processi

  1. glycogen biosynthetic process Source: RGD
  2. glycogen metabolic process Source: RGD
  3. heart development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

ReactomeiREACT_207828. Myoclonic epilepsy of Lafora.
REACT_214969. Glycogen synthesis.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase, muscle (EC:2.4.1.11)
Gene namesi
Name:Gys1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1589798. Gys1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. inclusion body Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 738737Glycogen [starch] synthase, muscle
PRO_0000366920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine; by AMPK and PKA By similarity
Modified residuei11 – 111Phosphoserine By similarity
Modified residuei641 – 6411Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASK By similarity
Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei657 – 6571Phosphoserine; by CK2 By similarity
Modified residuei698 – 6981Phosphoserine By similarity
Modified residuei728 – 7281Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2RRU1.
PRIDEiA2RRU1.

PTM databases

PhosphoSiteiA2RRU1.

Expressioni

Gene expression databases

GenevestigatoriA2RRU1.

Interactioni

Subunit structurei

Interacts with GYG1 By similarity.

Protein-protein interaction databases

BioGridi605796. 1 interaction.
STRINGi10116.ENSRNOP00000028271.

Structurei

3D structure databases

ProteinModelPortaliA2RRU1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiA2RRU1.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG741Z1N.
PhylomeDBiA2RRU1.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RRU1-1 [UniParc]FASTAAdd to Basket

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MPLSRSLSMS SLPGLEDWED EFDPENAVLF EVAWEVANKV GGIYTVLQTK    50
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPELKRT LDSMNSKGCK 100
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
AVLFGFLTTW FLGEFLAQNE EKPYVVAHFH EWLAGVGLCL CRARRLPVAT 200
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD IFLEALARLN 350
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI 550
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
LGRYYMSARH MALAKAFPDH FTYEPHEVDA TQGYRYPRPA SVPPSPSLSR 650
HSSPHQSEDE EEPRDGPLRE DSERYDEEEE AAKDRRNIRA PEWPRRASCS 700
SSTGGSKRSN SVDTGPSSSL STPTEPLSPT SSLGEERN 738
Length:738
Mass (Da):84,072
Last modified:March 6, 2007 - v1
Checksum:i912823E398F5263C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC131849 mRNA. Translation: AAI31850.1.
RefSeqiNP_001103085.1. NM_001109615.1.
UniGeneiRn.95278.

Genome annotation databases

EnsembliENSRNOT00000028271; ENSRNOP00000028271; ENSRNOG00000020812.
GeneIDi690987.
KEGGirno:690987.
UCSCiRGD:1589798. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC131849 mRNA. Translation: AAI31850.1 .
RefSeqi NP_001103085.1. NM_001109615.1.
UniGenei Rn.95278.

3D structure databases

ProteinModelPortali A2RRU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 605796. 1 interaction.
STRINGi 10116.ENSRNOP00000028271.

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

PTM databases

PhosphoSitei A2RRU1.

Proteomic databases

PaxDbi A2RRU1.
PRIDEi A2RRU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028271 ; ENSRNOP00000028271 ; ENSRNOG00000020812 .
GeneIDi 690987.
KEGGi rno:690987.
UCSCi RGD:1589798. rat.

Organism-specific databases

CTDi 2997.
RGDi 1589798. Gys1.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
InParanoidi A2RRU1.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG741Z1N.
PhylomeDBi A2RRU1.
TreeFami TF300306.

Enzyme and pathway databases

UniPathwayi UPA00164 .
Reactomei REACT_207828. Myoclonic epilepsy of Lafora.
REACT_214969. Glycogen synthesis.

Miscellaneous databases

NextBioi 742114.
PROi A2RRU1.

Gene expression databases

Genevestigatori A2RRU1.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGYS1_RAT
AccessioniPrimary (citable) accession number: A2RRU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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