Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A2RRU1

- GYS1_RAT

UniProt

A2RRU1 - GYS1_RAT

Protein

Glycogen [starch] synthase, muscle

Gene

Gys1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.By similarity

    Catalytic activityi

    UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

    Enzyme regulationi

    Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391UDP-glucoseBy similarity

    GO - Molecular functioni

    1. glucose binding Source: RGD
    2. glycogen (starch) synthase activity Source: RGD

    GO - Biological processi

    1. glycogen biosynthetic process Source: RGD
    2. glycogen metabolic process Source: RGD
    3. heart development Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_207828. Myoclonic epilepsy of Lafora.
    REACT_214969. Glycogen synthesis.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiGT3. Glycosyltransferase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen [starch] synthase, muscle (EC:2.4.1.11)
    Gene namesi
    Name:Gys1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1589798. Gys1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. inclusion body Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 738737Glycogen [starch] synthase, musclePRO_0000366920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81Phosphoserine; by AMPK and PKABy similarity
    Modified residuei11 – 111PhosphoserineBy similarity
    Modified residuei641 – 6411Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASKBy similarity
    Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei657 – 6571Phosphoserine; by CK2By similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Modified residuei728 – 7281PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA2RRU1.
    PRIDEiA2RRU1.

    PTM databases

    PhosphoSiteiA2RRU1.

    Expressioni

    Gene expression databases

    GenevestigatoriA2RRU1.

    Interactioni

    Subunit structurei

    Interacts with GYG1.By similarity

    Protein-protein interaction databases

    BioGridi605796. 1 interaction.
    STRINGi10116.ENSRNOP00000028271.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RRU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0438.
    GeneTreeiENSGT00390000018612.
    HOGENOMiHOG000160890.
    HOVERGENiHBG001960.
    InParanoidiA2RRU1.
    KOiK00693.
    OMAiFAMKRHG.
    OrthoDBiEOG741Z1N.
    PhylomeDBiA2RRU1.
    TreeFamiTF300306.

    Family and domain databases

    InterProiIPR008631. Glycogen_synth.
    [Graphical view]
    PANTHERiPTHR10176. PTHR10176. 1 hit.
    PfamiPF05693. Glycogen_syn. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2RRU1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLSRSLSMS SLPGLEDWED EFDPENAVLF EVAWEVANKV GGIYTVLQTK    50
    AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPELKRT LDSMNSKGCK 100
    VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
    AVLFGFLTTW FLGEFLAQNE EKPYVVAHFH EWLAGVGLCL CRARRLPVAT 200
    IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
    CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
    KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD IFLEALARLN 350
    YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
    GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
    DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
    HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI 550
    YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
    LGRYYMSARH MALAKAFPDH FTYEPHEVDA TQGYRYPRPA SVPPSPSLSR 650
    HSSPHQSEDE EEPRDGPLRE DSERYDEEEE AAKDRRNIRA PEWPRRASCS 700
    SSTGGSKRSN SVDTGPSSSL STPTEPLSPT SSLGEERN 738
    Length:738
    Mass (Da):84,072
    Last modified:March 6, 2007 - v1
    Checksum:i912823E398F5263C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC131849 mRNA. Translation: AAI31850.1.
    RefSeqiNP_001103085.1. NM_001109615.1.
    UniGeneiRn.95278.

    Genome annotation databases

    EnsembliENSRNOT00000028271; ENSRNOP00000028271; ENSRNOG00000020812.
    GeneIDi690987.
    KEGGirno:690987.
    UCSCiRGD:1589798. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC131849 mRNA. Translation: AAI31850.1 .
    RefSeqi NP_001103085.1. NM_001109615.1.
    UniGenei Rn.95278.

    3D structure databases

    ProteinModelPortali A2RRU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 605796. 1 interaction.
    STRINGi 10116.ENSRNOP00000028271.

    Protein family/group databases

    CAZyi GT3. Glycosyltransferase Family 3.

    PTM databases

    PhosphoSitei A2RRU1.

    Proteomic databases

    PaxDbi A2RRU1.
    PRIDEi A2RRU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028271 ; ENSRNOP00000028271 ; ENSRNOG00000020812 .
    GeneIDi 690987.
    KEGGi rno:690987.
    UCSCi RGD:1589798. rat.

    Organism-specific databases

    CTDi 2997.
    RGDi 1589798. Gys1.

    Phylogenomic databases

    eggNOGi COG0438.
    GeneTreei ENSGT00390000018612.
    HOGENOMi HOG000160890.
    HOVERGENi HBG001960.
    InParanoidi A2RRU1.
    KOi K00693.
    OMAi FAMKRHG.
    OrthoDBi EOG741Z1N.
    PhylomeDBi A2RRU1.
    TreeFami TF300306.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    Reactomei REACT_207828. Myoclonic epilepsy of Lafora.
    REACT_214969. Glycogen synthesis.

    Miscellaneous databases

    NextBioi 742114.
    PROi A2RRU1.

    Gene expression databases

    Genevestigatori A2RRU1.

    Family and domain databases

    InterProi IPR008631. Glycogen_synth.
    [Graphical view ]
    PANTHERi PTHR10176. PTHR10176. 1 hit.
    Pfami PF05693. Glycogen_syn. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiGYS1_RAT
    AccessioniPrimary (citable) accession number: A2RRU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3