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A2RRT3

- FB31A_XENLA

UniProt

A2RRT3 - FB31A_XENLA

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Protein
F-box only protein 31-A
Gene
fbxo31-a, fbxo31
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.

Pathwayi

GO - Biological processi

  1. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. cyclin catabolic process Source: UniProtKB
  4. mitotic G1 DNA damage checkpoint Source: UniProtKB
  5. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-A
Gene namesi
Name:fbxo31-a
Synonyms:fbxo31
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-953640. fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519F-box only protein 31-A
PRO_0000378164Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliA2RRT3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 10047F-box
Add
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.
Contains 1 F-box domain.

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RRT3-1 [UniParc]FASTAAdd to Basket

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MAMCARLCGV GQSGGCRRRQ QRKGAGNDPE LEDEEEEDEV RIEAGEAAVT    50
PRRPHSLLLL PPEILVEIFS LLPGTELGGL AQVCSKFRQI LTTDTIWKRR 100
CRQEYGVCEN LRKLEVTGVS CHDVYVKLLH QYRHILGLWQ PDIGPYGGLL 150
NVVVDGLFII GWMYLPPHDP HVDEAMRMKP VFRIHLMERK DATVECMYGH 200
KGPHNSQIQI VKKDEFSTKC LQTDYHRMSG GRQEEFRTWL REDLGRTLED 250
IFHEHMQELI LMKFIYICQY DNCLTYRRIY HPPSHPEDLL NPGFFKGTYG 300
SHGLEIVMLS FHGTIAKVTK ITGDPNVPAG QQTVEVDLTR PVQLPDVEHL 350
RNFDEMSRLI LDVQAQIHRE QRQTDNEEDD GRGAGPDKAE PAQQPAPLLR 400
PPNEDANGAD DDGDGGEQKP PNVQSFVLPA GVMARNEEYP RSCKMCFYGT 450
GLIAGHGFSS PERTPGLFIL FDEDRFGFIW LELKSFSLYS RMRDRFQQSE 500
APSLEAFEEM LQNMQSWTT 519
Length:519
Mass (Da):59,240
Last modified:March 6, 2007 - v1
Checksum:iAFBDE2BF7A5FAB17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC131839 mRNA. Translation: AAI31840.1.
RefSeqiNP_001091294.1. NM_001097825.1.
UniGeneiXl.51228.

Genome annotation databases

GeneIDi100037115.
KEGGixla:100037115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC131839 mRNA. Translation: AAI31840.1 .
RefSeqi NP_001091294.1. NM_001097825.1.
UniGenei Xl.51228.

3D structure databases

ProteinModelPortali A2RRT3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100037115.
KEGGi xla:100037115.

Organism-specific databases

CTDi 100037115.
Xenbasei XB-GENE-953640. fbxo31.

Phylogenomic databases

KOi K10308.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view ]
PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiFB31A_XENLA
AccessioniPrimary (citable) accession number: A2RRT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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