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A2RRT3

- FB31A_XENLA

UniProt

A2RRT3 - FB31A_XENLA

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Protein

F-box only protein 31-A

Gene

fbxo31-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. cyclin catabolic process Source: UniProtKB
  3. mitotic G1 DNA damage checkpoint Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-A
Gene namesi
Name:fbxo31-a
Synonyms:fbxo31
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-953640. fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519F-box only protein 31-APRO_0000378164Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2RRT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 10047F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RRT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMCARLCGV GQSGGCRRRQ QRKGAGNDPE LEDEEEEDEV RIEAGEAAVT
60 70 80 90 100
PRRPHSLLLL PPEILVEIFS LLPGTELGGL AQVCSKFRQI LTTDTIWKRR
110 120 130 140 150
CRQEYGVCEN LRKLEVTGVS CHDVYVKLLH QYRHILGLWQ PDIGPYGGLL
160 170 180 190 200
NVVVDGLFII GWMYLPPHDP HVDEAMRMKP VFRIHLMERK DATVECMYGH
210 220 230 240 250
KGPHNSQIQI VKKDEFSTKC LQTDYHRMSG GRQEEFRTWL REDLGRTLED
260 270 280 290 300
IFHEHMQELI LMKFIYICQY DNCLTYRRIY HPPSHPEDLL NPGFFKGTYG
310 320 330 340 350
SHGLEIVMLS FHGTIAKVTK ITGDPNVPAG QQTVEVDLTR PVQLPDVEHL
360 370 380 390 400
RNFDEMSRLI LDVQAQIHRE QRQTDNEEDD GRGAGPDKAE PAQQPAPLLR
410 420 430 440 450
PPNEDANGAD DDGDGGEQKP PNVQSFVLPA GVMARNEEYP RSCKMCFYGT
460 470 480 490 500
GLIAGHGFSS PERTPGLFIL FDEDRFGFIW LELKSFSLYS RMRDRFQQSE
510
APSLEAFEEM LQNMQSWTT
Length:519
Mass (Da):59,240
Last modified:March 6, 2007 - v1
Checksum:iAFBDE2BF7A5FAB17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131839 mRNA. Translation: AAI31840.1.
RefSeqiNP_001091294.1. NM_001097825.1.
UniGeneiXl.51228.

Genome annotation databases

GeneIDi100037115.
KEGGixla:100037115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131839 mRNA. Translation: AAI31840.1 .
RefSeqi NP_001091294.1. NM_001097825.1.
UniGenei Xl.51228.

3D structure databases

ProteinModelPortali A2RRT3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100037115.
KEGGi xla:100037115.

Organism-specific databases

CTDi 100037115.
Xenbasei XB-GENE-953640. fbxo31.

Phylogenomic databases

KOi K10308.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view ]
PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiFB31A_XENLA
AccessioniPrimary (citable) accession number: A2RRT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 6, 2007
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3