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A2RRT3 (FB31A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 31-A
Gene names
Name:fbxo31-a
Synonyms:fbxo31
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Sequence similarities

Belongs to the FBXO31 family.

Contains 1 F-box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519F-box only protein 31-A
PRO_0000378164

Regions

Domain54 – 10047F-box

Sequences

Sequence LengthMass (Da)Tools
A2RRT3 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: AFBDE2BF7A5FAB17

FASTA51959,240
        10         20         30         40         50         60 
MAMCARLCGV GQSGGCRRRQ QRKGAGNDPE LEDEEEEDEV RIEAGEAAVT PRRPHSLLLL 

        70         80         90        100        110        120 
PPEILVEIFS LLPGTELGGL AQVCSKFRQI LTTDTIWKRR CRQEYGVCEN LRKLEVTGVS 

       130        140        150        160        170        180 
CHDVYVKLLH QYRHILGLWQ PDIGPYGGLL NVVVDGLFII GWMYLPPHDP HVDEAMRMKP 

       190        200        210        220        230        240 
VFRIHLMERK DATVECMYGH KGPHNSQIQI VKKDEFSTKC LQTDYHRMSG GRQEEFRTWL 

       250        260        270        280        290        300 
REDLGRTLED IFHEHMQELI LMKFIYICQY DNCLTYRRIY HPPSHPEDLL NPGFFKGTYG 

       310        320        330        340        350        360 
SHGLEIVMLS FHGTIAKVTK ITGDPNVPAG QQTVEVDLTR PVQLPDVEHL RNFDEMSRLI 

       370        380        390        400        410        420 
LDVQAQIHRE QRQTDNEEDD GRGAGPDKAE PAQQPAPLLR PPNEDANGAD DDGDGGEQKP 

       430        440        450        460        470        480 
PNVQSFVLPA GVMARNEEYP RSCKMCFYGT GLIAGHGFSS PERTPGLFIL FDEDRFGFIW 

       490        500        510 
LELKSFSLYS RMRDRFQQSE APSLEAFEEM LQNMQSWTT 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC131839 mRNA. Translation: AAI31840.1.
RefSeqNP_001091294.1. NM_001097825.1.
UniGeneXl.51228.

3D structure databases

ProteinModelPortalA2RRT3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100037115.
KEGGxla:100037115.

Organism-specific databases

CTD100037115.
XenbaseXB-GENE-953640. fbxo31.

Phylogenomic databases

KOK10308.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

InterProIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFB31A_XENLA
AccessionPrimary (citable) accession number: A2RRT3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways