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Protein

F-box only protein 31-A

Gene

fbxo31-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. cyclin catabolic process Source: UniProtKB
  3. mitotic G1 DNA damage checkpoint Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31-A
Gene namesi
Name:fbxo31-a
Synonyms:fbxo31
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-953640. fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519F-box only protein 31-APRO_0000378164Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2RRT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 10047F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK10308.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RRT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMCARLCGV GQSGGCRRRQ QRKGAGNDPE LEDEEEEDEV RIEAGEAAVT
60 70 80 90 100
PRRPHSLLLL PPEILVEIFS LLPGTELGGL AQVCSKFRQI LTTDTIWKRR
110 120 130 140 150
CRQEYGVCEN LRKLEVTGVS CHDVYVKLLH QYRHILGLWQ PDIGPYGGLL
160 170 180 190 200
NVVVDGLFII GWMYLPPHDP HVDEAMRMKP VFRIHLMERK DATVECMYGH
210 220 230 240 250
KGPHNSQIQI VKKDEFSTKC LQTDYHRMSG GRQEEFRTWL REDLGRTLED
260 270 280 290 300
IFHEHMQELI LMKFIYICQY DNCLTYRRIY HPPSHPEDLL NPGFFKGTYG
310 320 330 340 350
SHGLEIVMLS FHGTIAKVTK ITGDPNVPAG QQTVEVDLTR PVQLPDVEHL
360 370 380 390 400
RNFDEMSRLI LDVQAQIHRE QRQTDNEEDD GRGAGPDKAE PAQQPAPLLR
410 420 430 440 450
PPNEDANGAD DDGDGGEQKP PNVQSFVLPA GVMARNEEYP RSCKMCFYGT
460 470 480 490 500
GLIAGHGFSS PERTPGLFIL FDEDRFGFIW LELKSFSLYS RMRDRFQQSE
510
APSLEAFEEM LQNMQSWTT
Length:519
Mass (Da):59,240
Last modified:March 6, 2007 - v1
Checksum:iAFBDE2BF7A5FAB17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131839 mRNA. Translation: AAI31840.1.
RefSeqiNP_001091294.1. NM_001097825.1.
UniGeneiXl.51228.

Genome annotation databases

GeneIDi100037115.
KEGGixla:100037115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131839 mRNA. Translation: AAI31840.1.
RefSeqiNP_001091294.1. NM_001097825.1.
UniGeneiXl.51228.

3D structure databases

ProteinModelPortaliA2RRT3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100037115.
KEGGixla:100037115.

Organism-specific databases

CTDi100037115.
XenbaseiXB-GENE-953640. fbxo31.

Phylogenomic databases

KOiK10308.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiFB31A_XENLA
AccessioniPrimary (citable) accession number: A2RRT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 6, 2007
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.