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Protein

Neuroblastoma-amplified sequence

Gene

NBAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Golgi-to-endoplasmic reticulum (ER) retrograde tranport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418).Curated1 Publication

GO - Molecular functioni

  • SNARE binding Source: UniProtKB

GO - Biological processi

  • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma-amplified sequence
Alternative name(s):
Neuroblastoma-amplified gene protein
Gene namesi
Name:NBAS
Synonyms:NAG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:15625. NBAS.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • Dsl1/NZR complex Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Short stature, optic nerve atrophy, and Pelger-Huet anomaly (SOPH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by severe postnatal growth retardation, facial dysmorphism with senile face, small hands and feet, normal intelligence, abnormal nuclear shape in neutrophil granulocytes (Pelger-Huet anomaly), and optic atrophy with loss of visual acuity and color vision.
See also OMIM:614800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0689571914R → H in SOPH. 1 PublicationCorresponds to variant rs369698072dbSNPEnsembl.1
Infantile liver failure syndrome 2 (ILFS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of infantile liver failure syndrome, a life-threatening disorder of hepatic function that manifests with acute liver failure in the first few months of life. Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis.
See also OMIM:616483
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074645187Missing in ILFS2. 1 Publication1
Natural variantiVAR_074646202Missing in ILFS2. 1 Publication1
Natural variantiVAR_074647348P → S in ILFS2. 1 Publication1
Natural variantiVAR_074649777P → H in ILFS2. 1 Publication1
Natural variantiVAR_074650842V → F in ILFS2. 1 Publication1
Natural variantiVAR_074651903L → R in ILFS2. 1 PublicationCorresponds to variant rs368196005dbSNPEnsembl.1
Natural variantiVAR_074652984I → S in ILFS2. 1 PublicationCorresponds to variant rs140841721dbSNPEnsembl.1
Natural variantiVAR_0746531055L → P in ILFS2. 1 PublicationCorresponds to variant rs796052121dbSNPEnsembl.1

NBAS mutations have been found in a multisystem disease affecting the liver, eye, immune system, connective tissue, and bone. Clinical manifestations include a progeroid appearance, short stature, slender bones, epiphyseal dysplasia with multiple phalangeal pseudo-epiphyses, cervical instability, myelopathy, elevated transaminases, hypogammaglobulinemia, reduced natural killer cells, Pelger-Huet anomaly of granulocytes, and in some cases retinal dystrophy and optic atrophy.

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi51594.
MalaCardsiNBAS.
MIMi614800. phenotype.
616483. phenotype.
OpenTargetsiENSG00000151779.
Orphaneti391677. Short stature-optic atrophy-Pelger-Huet anomaly syndrome.
PharmGKBiPA164723457.

Polymorphism and mutation databases

BioMutaiNBAS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928061 – 2371Neuroblastoma-amplified sequenceAdd BLAST2371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei473PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei1057N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2RRP1.
MaxQBiA2RRP1.
PaxDbiA2RRP1.
PRIDEiA2RRP1.

PTM databases

iPTMnetiA2RRP1.
PhosphoSitePlusiA2RRP1.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in heart and skeletal muscle, and lowest levels in liver, small intestine and thymus. Well expressed in retinal ganglion cells, epidermal skin cells, and leukocytes. Up-regulated together with N-myc in some neuroblastoma cell lines.4 Publications

Gene expression databases

BgeeiENSG00000151779.
ExpressionAtlasiA2RRP1. baseline and differential.
GenevisibleiA2RRP1. HS.

Organism-specific databases

HPAiHPA036817.

Interactioni

Subunit structurei

Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex); links NRZ to SNARE USE1L (PubMed:19369418).2 Publications

GO - Molecular functioni

  • SNARE binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119627. 17 interactors.
DIPiDIP-56726N.
IntActiA2RRP1. 13 interactors.
MINTiMINT-4838513.
STRINGi9606.ENSP00000281513.

Structurei

3D structure databases

ProteinModelPortaliA2RRP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati130 – 169WD 1Add BLAST40
Repeati316 – 355WD 2Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 1035Interaction with USE1L1 PublicationAdd BLAST1035
Regioni1036 – 2371Interaction with ZW10 and RINT12 PublicationsAdd BLAST1336

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1421 – 1425Poly-Thr5
Compositional biasi2242 – 2247Poly-Leu6

Sequence similaritiesi

Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1797. Eukaryota.
ENOG410YJNG. LUCA.
GeneTreeiENSGT00390000012474.
HOGENOMiHOG000113737.
InParanoidiA2RRP1.
KOiK20473.
OMAiIDVNWWA.
OrthoDBiEOG091G00Q2.
PhylomeDBiA2RRP1.
TreeFamiTF313901.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR029145. NBAS_N.
IPR011044. Quino_amine_DH_bsu.
IPR013244. Sec39_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF15492. Nbas_N. 1 hit.
PF08314. Sec39. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RRP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPESGPAL SPGTAEGEEE TILYDLLVNT EWPPETEVQP RGNQKHGASF
60 70 80 90 100
IITKAIRDRL LFLRQYIWYS PAPFLLPDGL VRLVNKQINW HLVLASNGKL
110 120 130 140 150
LAAVQDQCVE IRSAKDDFTS IIGKCQVPKD PKPQWRRVAW SYDCTLLAYA
160 170 180 190 200
ESTGTVRVFD LMGSELFVIS PASSFIGDLS YAIAGLIFLE YKASAQWSAE
210 220 230 240 250
LLVINYRGEL RSYLVSVGTN QSYQESHCFS FSSHYPHGIN TAIYHPGHRL
260 270 280 290 300
LLVGGCETAE VGMSKASSCG LSAWRVLSGS PYYKQVTNGG DGVTAVPKTL
310 320 330 340 350
GLLRMLSVKF YSRQGQEQDG IFKMSLSPDG MLLAAIHFSG KLSIWAIPSL
360 370 380 390 400
KQQGEWGQNE QPGYDDLNPD WRLSTEKRKK IKDKESFYPL IDVNWWADSA
410 420 430 440 450
VTLARCSGAL TVSSVKTLKN LLGKSCEWFE PSPQVTATHD GGFLSLECEI
460 470 480 490 500
KLAPKRSRLE TRAGEEDEGE EDSDSDYEIS AKARYFGYIK QGLYLVTEME
510 520 530 540 550
RFAPPRKRPR TITKNYRLVS LRSTTPEELY QRKIESEEYE EALSLAHTYG
560 570 580 590 600
LDTDLVYQRQ WRKSAVNVAS IQNYLSKIKK RSWVLHECLE RVPENVDAAK
610 620 630 640 650
ELLQYGLKGT DLEALLAIGK GADDGRFTLP GEIDIDSISY EELSPPDEEP
660 670 680 690 700
AKNKKEKELK KRQELLKLVN FSKLTLEQKE LCRCRRKLLT YLDRLATYEE
710 720 730 740 750
ILGVPHASEQ RYDAEFFKKF RNQNIVLSAR TYAQESNVQA LEILFTYHGS
760 770 780 790 800
DLLPHRLAIL SNFPETTSPH EYSVLLPEAC FNGDSLMIIP WHEHKHRAKD
810 820 830 840 850
WCEELACRMV VEPNLQDESE FLYAAQPELL RFRMTQLTVE KVMDWYQTRA
860 870 880 890 900
EEIEHYARQV DCALSLIRLG MERNIPGLLV LCDNLVTLET LVYEARCDVT
910 920 930 940 950
LTLKELQQMK DIEKLRLLMN SCSEDKYVTS AYQWMVPFLH RCEKQSPGVA
960 970 980 990 1000
NELLKEYLVT LAKGDLKFPL KIFQHSKPDL QQKIIPDQDQ LMAIALECIY
1010 1020 1030 1040 1050
TCERNDQLCL CYDLLECLPE RGYGDKTEAT TKLHDMVDQL EQILSVSELL
1060 1070 1080 1090 1100
EKHGLEKPIS FVKNTQSSSE EARKLMVRLT RHTGRKQPPV SESHWRTLLQ
1110 1120 1130 1140 1150
DMLTMQQNVY TCLDSDACYE IFTESLLCSS RLENIHLAGQ MMHCSACSEN
1160 1170 1180 1190 1200
PPAGIAHKGK PHYRVSYEKS IDLVLAASRE YFNSSTNLTD SCMDLARCCL
1210 1220 1230 1240 1250
QLITDRPPAI QEELDLIQAV GCLEEFGVKI LPLQVRLCPD RISLIKECIS
1260 1270 1280 1290 1300
QSPTCYKQST KLLGLAELLR VAGENPEERR GQVLILLVEQ ALRFHDYKAA
1310 1320 1330 1340 1350
SMHCQELMAT GYPKSWDVCS QLGQSEGYQD LATRQELMAF ALTHCPPSSI
1360 1370 1380 1390 1400
ELLLAASSSL QTEILYQRVN FQIHHEGGEN ISASPLTSKA VQEDEVGVPG
1410 1420 1430 1440 1450
SNSADLLRWT TATTMKVLSN TTTTTKAVLQ AVSDGQWWKK SLTYLRPLQG
1460 1470 1480 1490 1500
QKCGGAYQIG TTANEDLEKQ GCHPFYESVI SNPFVAESEG TYDTYQHVPV
1510 1520 1530 1540 1550
ESFAEVLLRT GKLAEAKNKG EVFPTTEVLL QLASEALPND MTLALAYLLA
1560 1570 1580 1590 1600
LPQVLDANRC FEKQSPSALS LQLAAYYYSL QIYARLAPCF RDKCHPLYRA
1610 1620 1630 1640 1650
DPKELIKMVT RHVTRHEHEA WPEDLISLTK QLHCYNERLL DFTQAQILQG
1660 1670 1680 1690 1700
LRKGVDVQRF TADDQYKRET ILGLAETLEE SVYSIAISLA QRYSVSRWEV
1710 1720 1730 1740 1750
FMTHLEFLFT DSGLSTLEIE NRAQDLHLFE TLKTDPEAFH QHMVKYIYPT
1760 1770 1780 1790 1800
IGGFDHERLQ YYFTLLENCG CADLGNCAIK PETHIRLLKK FKVVASGLNY
1810 1820 1830 1840 1850
KKLTDENMSP LEALEPVLSS QNILSISKLV PKIPEKDGQM LSPSSLYTIW
1860 1870 1880 1890 1900
LQKLFWTGDP HLIKQVPGSS PEWLHAYDVC MKYFDRLHPG DLITVVDAVT
1910 1920 1930 1940 1950
FSPKAVTKLS VEARKEMTRK AIKTVKHFIE KPRKRNSEDE AQEAKDSKVT
1960 1970 1980 1990 2000
YADTLNHLEK SLAHLETLSH SFILSLKNSE QETLQKYSHL YDLSRSEKEK
2010 2020 2030 2040 2050
LHDEAVAICL DGQPLAMIQQ LLEVAVGPLD ISPKDIVQSA IMKIISALSG
2060 2070 2080 2090 2100
GSADLGGPRD PLKVLEGVVA AVHASVDKGE ELVSPEDLLE WLRPFCADDA
2110 2120 2130 2140 2150
WPVRPRIHVL QILGQSFHLT EEDSKLLVFF RTEAILKASW PQRQVDIADI
2160 2170 2180 2190 2200
ENEENRYCLF MELLESSHHE AEFQHLVLLL QAWPPMKSEY VITNNPWVRL
2210 2220 2230 2240 2250
ATVMLTRCTM ENKEGLGNEV LKMCRSLYNT KQMLPAEGVK ELCLLLLNQS
2260 2270 2280 2290 2300
LLLPSLKLLL ESRDEHLHEM ALEQITAVTT VNDSNCDQEL LSLLLDAKLL
2310 2320 2330 2340 2350
VKCVSTPFYP RIVDHLLASL QQGRWDAEEL GRHLREAGHE AEAGSLLLAV
2360 2370
RGTHQAFRTF STALRAAQHW V
Length:2,371
Mass (Da):268,571
Last modified:March 3, 2009 - v2
Checksum:i54500EFAA487FB94
GO
Isoform 2 (identifier: A2RRP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     860-979: Missing.

Note: No experimental confirmation available.
Show »
Length:2,251
Mass (Da):254,816
Checksum:iC253AF9620FDA14E
GO

Sequence cautioni

The sequence AAD18133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAD18133 differs from that shown. Reason: Erroneous termination at position 2372. Translated as stop.Curated
The sequence CAB43382 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22I → T in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti533K → E in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti745F → L in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1102M → T in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1229K → E in AAD18133 (PubMed:9926938).Curated1
Sequence conflicti1277E → G in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1784H → Y in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1797G → S in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1854L → S in AAM93544 (PubMed:12706883).Curated1
Sequence conflicti1997E → D in AAD18133 (PubMed:9926938).Curated1
Sequence conflicti2028P → L in AAD18133 (PubMed:9926938).Curated1
Sequence conflicti2030D → N in AAD18133 (PubMed:9926938).Curated1
Sequence conflicti2033P → T in AAD18133 (PubMed:9926938).Curated1
Sequence conflicti2171A → T in AAD18133 (PubMed:9926938).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06895444Q → E.1 PublicationCorresponds to variant rs77081203dbSNPEnsembl.1
Natural variantiVAR_07464395A → V Probable disease-associated mutation found in patients with a multisystem disease involving liver, eye, immune system, connective tissue and bone. 1 Publication1
Natural variantiVAR_074644137R → W Probable disease-associated mutation found in patients with a multisystem disease involving liver, eye, immune system, connective tissue and bone. 1 PublicationCorresponds to variant rs368085185dbSNPEnsembl.1
Natural variantiVAR_074645187Missing in ILFS2. 1 Publication1
Natural variantiVAR_074646202Missing in ILFS2. 1 Publication1
Natural variantiVAR_057611243I → V.1 PublicationCorresponds to variant rs13029846dbSNPEnsembl.1
Natural variantiVAR_074647348P → S in ILFS2. 1 Publication1
Natural variantiVAR_074648396W → R Probable disease-associated mutation found in patients with a multisystem disease involving liver, eye, immune system, connective tissue and bone. 1 Publication1
Natural variantiVAR_057612655K → R.2 PublicationsCorresponds to variant rs4668909dbSNPEnsembl.1
Natural variantiVAR_074649777P → H in ILFS2. 1 Publication1
Natural variantiVAR_074650842V → F in ILFS2. 1 Publication1
Natural variantiVAR_074651903L → R in ILFS2. 1 PublicationCorresponds to variant rs368196005dbSNPEnsembl.1
Natural variantiVAR_068955949V → L.1 PublicationCorresponds to variant rs74727069dbSNPEnsembl.1
Natural variantiVAR_074652984I → S in ILFS2. 1 PublicationCorresponds to variant rs140841721dbSNPEnsembl.1
Natural variantiVAR_0576131004R → Q.Corresponds to variant rs16862653dbSNPEnsembl.1
Natural variantiVAR_0689561009C → S.1 PublicationCorresponds to variant rs74411619dbSNPEnsembl.1
Natural variantiVAR_0746531055L → P in ILFS2. 1 PublicationCorresponds to variant rs796052121dbSNPEnsembl.1
Natural variantiVAR_0576141178S → N.Corresponds to variant rs35770368dbSNPEnsembl.1
Natural variantiVAR_0689571914R → H in SOPH. 1 PublicationCorresponds to variant rs369698072dbSNPEnsembl.1
Natural variantiVAR_0576152074A → T.1 PublicationCorresponds to variant rs6710817dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026445860 – 979Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388385 mRNA. Translation: AAM93544.1.
AC007738 Genomic DNA. No translation available.
AC074184 Genomic DNA. No translation available.
AC008278 Genomic DNA. No translation available.
AC008282 Genomic DNA. Translation: AAY24347.1.
BC051792 mRNA. Translation: AAH51792.2.
BC108693 mRNA. Translation: AAI08694.1. Different termination.
BC131735 mRNA. Translation: AAI31736.1.
AF056195 mRNA. Translation: AAD18133.1. Sequence problems.
AL050281 mRNA. Translation: CAB43382.1. Different initiation.
CCDSiCCDS1685.1. [A2RRP1-1]
PIRiT13150.
RefSeqiNP_056993.2. NM_015909.3. [A2RRP1-1]
UniGeneiHs.467759.

Genome annotation databases

EnsembliENST00000281513; ENSP00000281513; ENSG00000151779. [A2RRP1-1]
GeneIDi51594.
KEGGihsa:51594.
UCSCiuc002rcc.3. human. [A2RRP1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388385 mRNA. Translation: AAM93544.1.
AC007738 Genomic DNA. No translation available.
AC074184 Genomic DNA. No translation available.
AC008278 Genomic DNA. No translation available.
AC008282 Genomic DNA. Translation: AAY24347.1.
BC051792 mRNA. Translation: AAH51792.2.
BC108693 mRNA. Translation: AAI08694.1. Different termination.
BC131735 mRNA. Translation: AAI31736.1.
AF056195 mRNA. Translation: AAD18133.1. Sequence problems.
AL050281 mRNA. Translation: CAB43382.1. Different initiation.
CCDSiCCDS1685.1. [A2RRP1-1]
PIRiT13150.
RefSeqiNP_056993.2. NM_015909.3. [A2RRP1-1]
UniGeneiHs.467759.

3D structure databases

ProteinModelPortaliA2RRP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119627. 17 interactors.
DIPiDIP-56726N.
IntActiA2RRP1. 13 interactors.
MINTiMINT-4838513.
STRINGi9606.ENSP00000281513.

PTM databases

iPTMnetiA2RRP1.
PhosphoSitePlusiA2RRP1.

Polymorphism and mutation databases

BioMutaiNBAS.

Proteomic databases

EPDiA2RRP1.
MaxQBiA2RRP1.
PaxDbiA2RRP1.
PRIDEiA2RRP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281513; ENSP00000281513; ENSG00000151779. [A2RRP1-1]
GeneIDi51594.
KEGGihsa:51594.
UCSCiuc002rcc.3. human. [A2RRP1-1]

Organism-specific databases

CTDi51594.
DisGeNETi51594.
GeneCardsiNBAS.
H-InvDBHIX0001840.
HGNCiHGNC:15625. NBAS.
HPAiHPA036817.
MalaCardsiNBAS.
MIMi608025. gene.
614800. phenotype.
616483. phenotype.
neXtProtiNX_A2RRP1.
OpenTargetsiENSG00000151779.
Orphaneti391677. Short stature-optic atrophy-Pelger-Huet anomaly syndrome.
PharmGKBiPA164723457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1797. Eukaryota.
ENOG410YJNG. LUCA.
GeneTreeiENSGT00390000012474.
HOGENOMiHOG000113737.
InParanoidiA2RRP1.
KOiK20473.
OMAiIDVNWWA.
OrthoDBiEOG091G00Q2.
PhylomeDBiA2RRP1.
TreeFamiTF313901.

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiNBAS. human.
GenomeRNAii51594.
PROiA2RRP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151779.
ExpressionAtlasiA2RRP1. baseline and differential.
GenevisibleiA2RRP1. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR029145. NBAS_N.
IPR011044. Quino_amine_DH_bsu.
IPR013244. Sec39_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF15492. Nbas_N. 1 hit.
PF08314. Sec39. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNBAS_HUMAN
AccessioniPrimary (citable) accession number: A2RRP1
Secondary accession number(s): O95790
, Q2VPJ7, Q53TK6, Q86V39, Q8NFY8, Q9Y3W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.