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Protein

Transmembrane protein 213

Gene

TMEM213

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 213
Gene namesi
Name:TMEM213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27220. TMEM213.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 7043ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 10716CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406494.

Polymorphism and mutation databases

BioMutaiTMEM213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 10780Transmembrane protein 213PRO_0000337054Add
BLAST

Proteomic databases

PaxDbiA2RRL7.
PRIDEiA2RRL7.

Expressioni

Gene expression databases

BgeeiENSG00000214128.
CleanExiHS_TMEM213.
GenevisibleiA2RRL7. HS.

Organism-specific databases

HPAiHPA054059.

Interactioni

Protein-protein interaction databases

BioGridi127567. 7 interactions.
STRINGi9606.ENSP00000390407.

Structurei

3D structure databases

ProteinModelPortaliA2RRL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J39B. Eukaryota.
ENOG411196J. LUCA.
GeneTreeiENSGT00390000014153.
HOGENOMiHOG000154626.
HOVERGENiHBG095879.
InParanoidiA2RRL7.
OMAiRCCRAGV.
OrthoDBiEOG091G17B8.
PhylomeDBiA2RRL7.
TreeFamiTF336187.

Family and domain databases

InterProiIPR028121. TMEM213.
[Graphical view]
PfamiPF15192. TMEM213. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2RRL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLPAATRA TLILSLAFAS LHSACSAEAS SSNSSSLTAH HPDPGTLEQC
60 70 80 90 100
LNVDFCPQAA RCCRTGVDEY GWIAAAVGWS LWFLTLILLC VDKLMKLTPD

EPKDLQA
Note: Gene prediction based on EST data.
Length:107
Mass (Da):11,520
Last modified:August 10, 2010 - v2
Checksum:iBDE87C507C11E0D3
GO
Isoform 2 (identifier: A2RRL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-52: EASSSNSSSLTAHHPDPGTLEQCLN → D

Note: Gene prediction based on EST data.
Show »
Length:83
Mass (Da):9,071
Checksum:i73B38E1FA5687D74
GO
Isoform 3 (identifier: A2RRL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):11,391
Checksum:i4934C5D10F5165C0
GO
Isoform 4 (identifier: A2RRL7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-107: NVDFCPQAAR...TPDEPKDLQA → RSGYLANLRG...GWRSSVELVG

Note: Gene prediction based on EST data.
Show »
Length:105
Mass (Da):11,555
Checksum:i29AAA003103DD050
GO

Sequence cautioni

The sequence AAI31698 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 5225EASSS…EQCLN → D in isoform 2. CuratedVSP_039555Add
BLAST
Alternative sequencei28 – 281Missing in isoform 3. 1 PublicationVSP_039556
Alternative sequencei52 – 10756NVDFC…KDLQA → RSGYLANLRGEADQLWKFCT VLCFWESRRSSSRIALMREA EEWPGWRSSVELVG in isoform 4. CuratedVSP_039557Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018663 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24042.1.
CH471070 Genomic DNA. Translation: EAW83898.1.
BC131697 mRNA. Translation: AAI31698.1. Different initiation.
CCDSiCCDS47722.1. [A2RRL7-1]
RefSeqiNP_001078898.1. NM_001085429.1. [A2RRL7-1]
XP_005250224.1. XM_005250167.3.
UniGeneiHs.567729.

Genome annotation databases

EnsembliENST00000397602; ENSP00000380727; ENSG00000214128. [A2RRL7-3]
ENST00000413208; ENSP00000401570; ENSG00000214128. [A2RRL7-4]
ENST00000442682; ENSP00000390407; ENSG00000214128. [A2RRL7-1]
ENST00000458494; ENSP00000393891; ENSG00000214128. [A2RRL7-2]
GeneIDi155006.
KEGGihsa:155006.
UCSCiuc010lna.5. human. [A2RRL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018663 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24042.1.
CH471070 Genomic DNA. Translation: EAW83898.1.
BC131697 mRNA. Translation: AAI31698.1. Different initiation.
CCDSiCCDS47722.1. [A2RRL7-1]
RefSeqiNP_001078898.1. NM_001085429.1. [A2RRL7-1]
XP_005250224.1. XM_005250167.3.
UniGeneiHs.567729.

3D structure databases

ProteinModelPortaliA2RRL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127567. 7 interactions.
STRINGi9606.ENSP00000390407.

Polymorphism and mutation databases

BioMutaiTMEM213.

Proteomic databases

PaxDbiA2RRL7.
PRIDEiA2RRL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397602; ENSP00000380727; ENSG00000214128. [A2RRL7-3]
ENST00000413208; ENSP00000401570; ENSG00000214128. [A2RRL7-4]
ENST00000442682; ENSP00000390407; ENSG00000214128. [A2RRL7-1]
ENST00000458494; ENSP00000393891; ENSG00000214128. [A2RRL7-2]
GeneIDi155006.
KEGGihsa:155006.
UCSCiuc010lna.5. human. [A2RRL7-1]

Organism-specific databases

CTDi155006.
GeneCardsiTMEM213.
HGNCiHGNC:27220. TMEM213.
HPAiHPA054059.
neXtProtiNX_A2RRL7.
PharmGKBiPA162406494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J39B. Eukaryota.
ENOG411196J. LUCA.
GeneTreeiENSGT00390000014153.
HOGENOMiHOG000154626.
HOVERGENiHBG095879.
InParanoidiA2RRL7.
OMAiRCCRAGV.
OrthoDBiEOG091G17B8.
PhylomeDBiA2RRL7.
TreeFamiTF336187.

Miscellaneous databases

GenomeRNAii155006.
PROiA2RRL7.

Gene expression databases

BgeeiENSG00000214128.
CleanExiHS_TMEM213.
GenevisibleiA2RRL7. HS.

Family and domain databases

InterProiIPR028121. TMEM213.
[Graphical view]
PfamiPF15192. TMEM213. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM213_HUMAN
AccessioniPrimary (citable) accession number: A2RRL7
Secondary accession number(s): A4D1R3
, C9JH49, C9JX41, C9K0P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.