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Protein
Submitted name:

Bcr protein

Gene

Bcr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Bcr proteinImported
Gene namesi
Name:BcrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88141. Bcr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA2RRK7.
PeptideAtlasiA2RRK7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009681.
GenevisibleiA2RRK7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126377.

Structurei

3D structure databases

ProteinModelPortaliA2RRK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 403194DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini420 – 578159PHInterPro annotationAdd
BLAST
Domaini582 – 714133C2InterPro annotationAdd
BLAST
Domaini766 – 960195Rho-GAPInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains PH domain.SAAS annotation
Contains Rho-GAP domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
HOVERGENiHBG004165.
KOiK08878.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RRK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVEGEGKSP LLRSQSTSEQ EKRLTWPRRS YSPRSFEDSG GGYTPDCSSN
60 70 80 90 100
ENLTSSEEDF SSGQSSRVSP SPTTYRMFRD KSRSPSQNSQ QSFDSSSPPT
110 120 130 140 150
PQCQKRHRQC QVVVSEATIV GVRKTGQIWP SDGDSTFQGE ADSSFGTPPG
160 170 180 190 200
YGCAADQAEE QRRHQDGLPY IDDSPSSSPH LSSKGRGSLA SGALDPTKVS
210 220 230 240 250
ELDLEKGLEM RKWVLSGILA SEETYLSHLE ALLLPMKPLK AAATTSQPVL
260 270 280 290 300
TSQQIETIFF KVPELYEIHK EFYDGLFPRV QQWSHQQRVG DLFQKLASQL
310 320 330 340 350
GVYRAFVDNY GVAMETAEKC CQANAQFAEI SENLRARSNK DVKDSTTKNS
360 370 380 390 400
LETLLYKPVD RVTRSTLVLH DLLKHTPSSH PDHSLLQDAL RISQNFLSSI
410 420 430 440 450
NEEITPRRQS MTVKKGEHRQ LLKDSFMVEL VEGARKLRHI FLFTDLLLCT
460 470 480 490 500
KLKKQSGGKT QQYDCKWYIP LTDLSFQMVD ELEALPNIPL VPDEELDALK
510 520 530 540 550
IKISQIKSDI QREKRANKGS KVMERLRKKL SEQESLLLLM SPSMAFRVHS
560 570 580 590 600
RNGKSYTFLI SSDYERAEWR ESIREQQKKC FKSFSLTSVE LQMLTNSCVK
610 620 630 640 650
LQTVHHIPLT INKEDDESPG LYGFLHVIVH SATGFKQSSN LYCTLEVDSF
660 670 680 690 700
GYFVNKAKTR VYRDTTEPNW NEEFEIELEG SQTLRILCYE KCYNKMKMTK
710 720 730 740 750
EDGESADKLM GKGQVQLDPQ TLQDRDWQRT VIDMNGIEVK LSVKFTSREF
760 770 780 790 800
SLKRMPSRKQ TGVFGVKIAV VTKRERSKVP YIVRQCVEEI ERRGMEEVGI
810 820 830 840 850
YRVSGVATDI QALKAAFDVN NKDVSVMMSE MDVNAIAGTL KLYFRELPEP
860 870 880 890 900
LFTDEFYPNF AEGIALSDPV AKESCMLNLL LSLPEANLLT FLFLLDHLKR
910 920 930 940 950
VAEKETVNKM SLHNLATVFG PTLLRPSEKE SKLPANPSQP ITMTDSWSLE
960 970 980
VMSQVQVLLY FLQLEAIPAP DSKRQSILFS TEV
Length:983
Mass (Da):111,408
Last modified:March 6, 2007 - v1
Checksum:i646342E79412DECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131682 mRNA. Translation: AAI31683.1.
RefSeqiNP_001074881.1. NM_001081412.2.
UniGeneiMm.333722.

Genome annotation databases

GeneIDi110279.
KEGGimmu:110279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131682 mRNA. Translation: AAI31683.1.
RefSeqiNP_001074881.1. NM_001081412.2.
UniGeneiMm.333722.

3D structure databases

ProteinModelPortaliA2RRK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126377.

Proteomic databases

PaxDbiA2RRK7.
PeptideAtlasiA2RRK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi110279.
KEGGimmu:110279.

Organism-specific databases

CTDi613.
MGIiMGI:88141. Bcr.

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
HOVERGENiHBG004165.
KOiK08878.

Miscellaneous databases

ChiTaRSiBcr. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009681.
GenevisibleiA2RRK7. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2RRK7_MOUSE
AccessioniPrimary (citable) accession number: A2RRK7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.