A2RRH5 (WDR27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 27

Gene names

Name:

WDR27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 10 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2RRH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2RRH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-207: Missing.

Isoform 3 (identifier: A2RRH5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     111-112: GL → GK
     113-827: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: A2RRH5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     152-152: E → EQRFSVTYIERPDVNNRHKVPPPTFLHTFSQ
     812-827: LATATLDGKLQLFLAE → MESCSVAHAGVQWHDLGSLQPPPSRFKQFFCLSFPSSWDYSLPQLPWMVNSSSF

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 827	827	WD repeat-containing protein 27		PRO_0000306831
Regions
	Repeat	26 – 65	40	WD 1
	Repeat	69 – 109	41	WD 2
	Repeat	162 – 202	41	WD 3
	Repeat	206 – 245	40	WD 4
	Repeat	511 – 550	40	WD 5
	Repeat	553 – 592	40	WD 6
	Repeat	655 – 695	41	WD 7
	Repeat	699 – 748	50	WD 8
	Repeat	753 – 792	40	WD 9
	Repeat	795 – 827	33	WD 10
Natural variations
	Alternative sequence	111 – 207	97	Missing in isoform 2.		VSP_028510
	Alternative sequence	111 – 112	2	GL → GK in isoform 3.		VSP_028511
	Alternative sequence	113 – 827	715	Missing in isoform 3.		VSP_028512
	Alternative sequence	152	1	E → EQRFSVTYIERPDVNNRHKV PPPTFLHTFSQ in isoform 4.		VSP_040796
	Alternative sequence	812 – 827	16	LATAT…LFLAE → MESCSVAHAGVQWHDLGSLQ PPPSRFKQFFCLSFPSSWDY SLPQLPWMVNSSSF in isoform 4.		VSP_040797
	Natural variant	133	1	L → P. Ref.2 Corresponds to variant rs4236176 [ dbSNP | Ensembl ].		VAR_035317
	Natural variant	393	1	V → L. Corresponds to variant rs35895089 [ dbSNP | Ensembl ].		VAR_035318
	Natural variant	437	1	R → H. Ref.2 Corresponds to variant rs3800544 [ dbSNP | Ensembl ].		VAR_035319
	Natural variant	470	1	P → L. Corresponds to variant rs34313252 [ dbSNP | Ensembl ].		VAR_035320
	Natural variant	697	1	A → V. Corresponds to variant rs9396946 [ dbSNP | Ensembl ].		VAR_035321
Experimental info
	Sequence conflict	153	1	T → A in BC040606. Ref.2
	Sequence conflict	512	1	T → S in AAI31634. Ref.2
	Sequence conflict	512	1	T → S in AAI42983. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 932404623943AC4C	FASTA	827	90,038
	10 20 30 40 50 60 MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP 70 80 90 100 110 120 SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ GLVPRGTVMG 130 140 150 160 170 180 SLLGKVLCLQ LSLDDHVVAV CAGNKIFMLD IETQAVRAEL QGHLGPVTAV EFCPWRAGTL 190 200 210 220 230 240 ISASEDRGFK VWDHCTGSLI YSSSVLSAYP LLSLFIDAES RQLVTGCADG QLWIFSLMDG 250 260 270 280 290 300 HHYRRVARVD LRKKTETFST RRVKSGLCSQ PEESQLPSTS ALGKGEQVEV TFPVLRLAPC 310 320 330 340 350 360 DLSLIPNSAC GCLSSENTRC VWIGSSVGLF VFNLANLEVE AALYYKDFQS LSILLAGSCA 370 380 390 400 410 420 LRNRTADQKV LCLLASLFGG KIAVLEINPA ALVRAQQCPS MGQSLSVPAS SCVLPTSPLY 430 440 450 460 470 480 LGIAKEKSTK AASEQRRAAR NVMKDQRLVF HSKVRSSGYA SAPHVTMFSP KTNIKSEGKG 490 500 510 520 530 540 SSRSRSSCAR EAYPVECAVP TKPGPQVAAA PTCTRVCCIQ YSGDGQWLAC GLANHLLLVF 550 560 570 580 590 600 DASLTGTPAV FSGHDGAVNA VCWSQDRRWL LSAARDGTLR MWSARGAELA LLLGKDMFSK 610 620 630 640 650 660 PIQSAQFYYI DAFILLSSGP EFQLLRYHID TCKDEIKRYK QKSKSKLICR LSTTGAVDMT 670 680 690 700 710 720 SLSAVNDFYS HIVLAAGRNR TVEVFDLNAG CSAAVIAEAH SRPVHQICQN KGSSFTTQQP 730 740 750 760 770 780 QAYNLFLTTA IGDGMRLWDL RTLRCERHFE GHPTRGYPCG IAFSPCGRFA ACGAEDRHAY 790 800 810 820 VYEMGSSTFS HRLAGHTDTV TGVAFNPSAP QLATATLDGK LQLFLAE
	Isoform 2 [UniParc]. Checksum: 58ECDFE7DD65F7DF	FASTA	730	79,712
	10 20 30 40 50 60 MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP 70 80 90 100 110 120 SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ AYPLLSLFID 130 140 150 160 170 180 AESRQLVTGC ADGQLWIFSL MDGHHYRRVA RVDLRKKTET FSTRRVKSGL CSQPEESQLP 190 200 210 220 230 240 STSALGKGEQ VEVTFPVLRL APCDLSLIPN SACGCLSSEN TRCVWIGSSV GLFVFNLANL 250 260 270 280 290 300 EVEAALYYKD FQSLSILLAG SCALRNRTAD QKVLCLLASL FGGKIAVLEI NPAALVRAQQ 310 320 330 340 350 360 CPSMGQSLSV PASSCVLPTS PLYLGIAKEK STKAASEQRR AARNVMKDQR LVFHSKVRSS 370 380 390 400 410 420 GYASAPHVTM FSPKTNIKSE GKGSSRSRSS CAREAYPVEC AVPTKPGPQV AAAPTCTRVC 430 440 450 460 470 480 CIQYSGDGQW LACGLANHLL LVFDASLTGT PAVFSGHDGA VNAVCWSQDR RWLLSAARDG 490 500 510 520 530 540 TLRMWSARGA ELALLLGKDM FSKPIQSAQF YYIDAFILLS SGPEFQLLRY HIDTCKDEIK 550 560 570 580 590 600 RYKQKSKSKL ICRLSTTGAV DMTSLSAVND FYSHIVLAAG RNRTVEVFDL NAGCSAAVIA 610 620 630 640 650 660 EAHSRPVHQI CQNKGSSFTT QQPQAYNLFL TTAIGDGMRL WDLRTLRCER HFEGHPTRGY 670 680 690 700 710 720 PCGIAFSPCG RFAACGAEDR HAYVYEMGSS TFSHRLAGHT DTVTGVAFNP SAPQLATATL 730 DGKLQLFLAE
	Isoform 3 [UniParc]. Checksum: 6A21DD6CDF3ABB66	FASTA	112	12,522
	10 20 30 40 50 60 MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP 70 80 90 100 110 SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ GK
	Isoform 4 [UniParc]. Checksum: 0D542A76F932AD37	FASTA	895	98,077
	10 20 30 40 50 60 MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP 70 80 90 100 110 120 SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ GLVPRGTVMG 130 140 150 160 170 180 SLLGKVLCLQ LSLDDHVVAV CAGNKIFMLD IEQRFSVTYI ERPDVNNRHK VPPPTFLHTF 190 200 210 220 230 240 SQTQAVRAEL QGHLGPVTAV EFCPWRAGTL ISASEDRGFK VWDHCTGSLI YSSSVLSAYP 250 260 270 280 290 300 LLSLFIDAES RQLVTGCADG QLWIFSLMDG HHYRRVARVD LRKKTETFST RRVKSGLCSQ 310 320 330 340 350 360 PEESQLPSTS ALGKGEQVEV TFPVLRLAPC DLSLIPNSAC GCLSSENTRC VWIGSSVGLF 370 380 390 400 410 420 VFNLANLEVE AALYYKDFQS LSILLAGSCA LRNRTADQKV LCLLASLFGG KIAVLEINPA 430 440 450 460 470 480 ALVRAQQCPS MGQSLSVPAS SCVLPTSPLY LGIAKEKSTK AASEQRRAAR NVMKDQRLVF 490 500 510 520 530 540 HSKVRSSGYA SAPHVTMFSP KTNIKSEGKG SSRSRSSCAR EAYPVECAVP TKPGPQVAAA 550 560 570 580 590 600 PTCTRVCCIQ YSGDGQWLAC GLANHLLLVF DASLTGTPAV FSGHDGAVNA VCWSQDRRWL 610 620 630 640 650 660 LSAARDGTLR MWSARGAELA LLLGKDMFSK PIQSAQFYYI DAFILLSSGP EFQLLRYHID 670 680 690 700 710 720 TCKDEIKRYK QKSKSKLICR LSTTGAVDMT SLSAVNDFYS HIVLAAGRNR TVEVFDLNAG 730 740 750 760 770 780 CSAAVIAEAH SRPVHQICQN KGSSFTTQQP QAYNLFLTTA IGDGMRLWDL RTLRCERHFE 790 800 810 820 830 840 GHPTRGYPCG IAFSPCGRFA ACGAEDRHAY VYEMGSSTFS HRLAGHTDTV TGVAFNPSAP 850 860 870 880 890 QMESCSVAHA GVQWHDLGSL QPPPSRFKQF FCLSFPSSWD YSLPQLPWMV NSSSF

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANTS PRO-133 AND HIS-437.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031315 Genomic DNA. No translation available. AL135910 Genomic DNA. No translation available. AL441927 Genomic DNA. No translation available. AL513547 Genomic DNA. Translation: CAI12313.1. BC040606 mRNA. No translation available. BC131633 mRNA. Translation: AAI31634.1. BC142982 mRNA. Translation: AAI42983.1.
IPI	IPI00867634. IPI00902979. IPI00908536. IPI01008842.
RefSeq	NP_001189479.1. NM_001202550.1.
UniGene	Hs.131903.
3D structure databases
ProteinModelPortal	A2RRH5.
SMR	A2RRH5. Positions 116-242, 517-584, 673-825.
ModBase	Search...
PTM databases
PhosphoSite	A2RRH5.
Proteomic databases
PRIDE	A2RRH5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000401031; ENSP00000383811; ENSG00000184465.
GeneID	253769.
KEGG	hsa:253769.
UCSC	uc003qwy.2. human. uc010kkw.1. human. uc010kkx.1. human.
Organism-specific databases
CTD	253769.
GeneCards	GC06M169857.
HGNC	HGNC:21248. WDR27.
HPA	HPA037497.
neXtProt	NX_A2RRH5.
PharmGKB	PA134875091.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18973.
HOVERGEN	HBG108668.
Gene expression databases
CleanEx	HS_WDR27.
Genevestigator	A2RRH5.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 10 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	92163.

Entry information

Entry name

WDR27_HUMAN

Accession

Primary (citable) accession number: A2RRH5
Secondary accession number(s): A5PLM8, Q5T066

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	April 5, 2011
Last modified:	January 25, 2012
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.