ID   A2RRE0_HUMAN            Unreviewed;       815 AA.
AC   A2RRE0;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   24-JAN-2024, entry version 125.
DE   SubName: Full=WDR7 protein {ECO:0000313|EMBL:AAI31559.1};
GN   Name=WDR7 {ECO:0000313|EMBL:AAI31559.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI31559.1};
RN   [1] {ECO:0000313|EMBL:AAI31559.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0007829|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [4] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- INTERACTION:
CC       A2RRE0; Q96NE9: FRMD6; NbExp=3; IntAct=EBI-10291832, EBI-741729;
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DR   EMBL; BC131558; AAI31559.1; -; mRNA.
DR   AlphaFoldDB; A2RRE0; -.
DR   SMR; A2RRE0; -.
DR   IntAct; A2RRE0; 1.
DR   MassIVE; A2RRE0; -.
DR   MaxQB; A2RRE0; -.
DR   PeptideAtlas; A2RRE0; -.
DR   ProteomicsDB; 463; -.
DR   Antibodypedia; 62690; 22 antibodies from 11 providers.
DR   UCSC; uc060plr.1; human.
DR   VEuPathDB; HostDB:ENSG00000091157; -.
DR   HOGENOM; CLU_027904_2_0_1; -.
DR   ChiTaRS; WDR7; human.
DR   Bgee; ENSG00000091157; Expressed in endothelial cell and 201 other cell types or tissues.
DR   ExpressionAtlas; A2RRE0; baseline and differential.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44099; RABCONNECTIN-3B, ISOFORM A; 1.
DR   PANTHER; PTHR44099:SF3; WD REPEAT-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
PE   1: Evidence at protein level;
SQ   SEQUENCE   815 AA;  89344 MW;  B33944DE3174B27A CRC64;
     MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV ELQINPRALL
     FGHTAVLFQQ VKETIKENIK EHLLDDEEED EEIMRQRREE SDPEYRSSKS KPLTLLEYNL
     TMDTAKLFMS CLHAWGLNEV LDEVCLDRLG MLKPHCTVSF GLLSRGGHMS LMLPGYNQPA
     CKLSHGKTEV GRKLPASEGV GKGTYGVSRA VTTQHLLSII SLANTLMSMT NATFIGDHMK
     KGPTRPPRPS TPDLSKARGS PPTSSNIVQG QIKQVAAPVV SARSDADHSG SDPPSAPALH
     TCFLVNEGWS QLAAMHCVML PDLLGLDKFR PPLLEMLARR WQDRCLEVRE AAQALLLAEL
     RRIEQAGRKE AIDAWAPYLP QYIDHVISPG VTSEAAQTIT TAPDASGPEA KVQEEEHDLV
     DDDITTGCLS SVPQMKKIST SYEERRKQAT AIVLLGVIGA EFGAEIEPPK LLTRPRSSSQ
     IPEGFGLTSG GSNYSLARHT CKALTFLLLQ PPSPKLPPHS TIRRTAIDLI GRGFTVWEPY
     MDVSAVLMGL LELCADAEKQ LANITMGLPL SPAADSARSA RHALSLIATA RPPAFITTIA
     KEVHRHTALA ANTQSQQNMH TTTLARAKGE ILRVIEILIE KMPTDVVDLL VEVMDIIMYC
     LEGSLVKKKG LQECFPAICR FYMVSYYERN HRIAVGARHG SVALYDIRTG KCQTIHGHKG
     PITAVAFAPD GRYLATYSNT DSHISFWQMN TSLLGSIGML NSAPQLRCIK TYQVPPVQPA
     SPGSHNALKL ARLIWTSNRN VILMAHDGKE HRFMV
//