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Protein

Zinc finger protein 320

Gene

ZNF320

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 320
Gene namesi
Name:ZNF320
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13842. ZNF320.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZNF320 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with BRWD2/WDR11.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA37819.

Polymorphism and mutation databases

BioMutaiZNF320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Zinc finger protein 320PRO_0000300263Add
BLAST

Proteomic databases

EPDiA2RRD8.
MaxQBiA2RRD8.
PaxDbiA2RRD8.
PeptideAtlasiA2RRD8.
PRIDEiA2RRD8.

PTM databases

iPTMnetiA2RRD8.
PhosphoSiteiA2RRD8.

Expressioni

Tissue specificityi

Expressed at high levels in placenta, pancreas, kidney and heart, and at lower levels in liver, skeletal muscle and brain.1 Publication

Gene expression databases

BgeeiA2RRD8.
CleanExiHS_ZNF320.
ExpressionAtlasiA2RRD8. baseline and differential.
GenevisibleiA2RRD8. HS.

Organism-specific databases

HPAiHPA043696.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-10173019,EBI-10172150
KRTAP10-7P604093EBI-10173019,EBI-10172290

Protein-protein interaction databases

BioGridi127834. 3 interactions.
IntActiA2RRD8. 2 interactions.
STRINGi9606.ENSP00000375660.

Structurei

3D structure databases

ProteinModelPortaliA2RRD8.
SMRiA2RRD8. Positions 8-47, 147-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8073KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA2RRD8.
KOiK09228.
OMAiKATLACH.
PhylomeDBiA2RRD8.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RRD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMNTLSS TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ
110 120 130 140 150
WQEDETNDHE APMTEIKKLT SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR
160 170 180 190 200
HRRIHTGEKP YKCEECEKVF SCKSHLEIHR IIHTGEKPYK CKVCDKAFKH
210 220 230 240 250
DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT GEKPYKCNEC
260 270 280 290 300
GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP
310 320 330 340 350
YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI
360 370 380 390 400
HTGEKPYKCK VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL
410 420 430 440 450
ACHQKLHTGE KLYECEECDK VYIRKSHLER HRRIHTGEKP HKCGDCGKAF
460 470 480 490 500
NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL RSLLAEHQKI PFGDNCFKCN

EYSKPSSIN
Length:509
Mass (Da):59,326
Last modified:March 6, 2007 - v1
Checksum:i2D221BC43C684B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131555 mRNA. Translation: AAI31556.1.
AL831902 mRNA. Translation: CAD38570.1.
CCDSiCCDS33095.1.
RefSeqiNP_997216.2. NM_207333.2.
XP_006723122.1. XM_006723059.2.
UniGeneiHs.369632.

Genome annotation databases

EnsembliENST00000391781; ENSP00000375660; ENSG00000182986.
ENST00000595635; ENSP00000473091; ENSG00000182986.
GeneIDi162967.
KEGGihsa:162967.
UCSCiuc002qai.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131555 mRNA. Translation: AAI31556.1.
AL831902 mRNA. Translation: CAD38570.1.
CCDSiCCDS33095.1.
RefSeqiNP_997216.2. NM_207333.2.
XP_006723122.1. XM_006723059.2.
UniGeneiHs.369632.

3D structure databases

ProteinModelPortaliA2RRD8.
SMRiA2RRD8. Positions 8-47, 147-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127834. 3 interactions.
IntActiA2RRD8. 2 interactions.
STRINGi9606.ENSP00000375660.

PTM databases

iPTMnetiA2RRD8.
PhosphoSiteiA2RRD8.

Polymorphism and mutation databases

BioMutaiZNF320.

Proteomic databases

EPDiA2RRD8.
MaxQBiA2RRD8.
PaxDbiA2RRD8.
PeptideAtlasiA2RRD8.
PRIDEiA2RRD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391781; ENSP00000375660; ENSG00000182986.
ENST00000595635; ENSP00000473091; ENSG00000182986.
GeneIDi162967.
KEGGihsa:162967.
UCSCiuc002qai.4. human.

Organism-specific databases

CTDi162967.
GeneCardsiZNF320.
HGNCiHGNC:13842. ZNF320.
HPAiHPA043696.
MIMi606427. gene.
neXtProtiNX_A2RRD8.
PharmGKBiPA37819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA2RRD8.
KOiK09228.
OMAiKATLACH.
PhylomeDBiA2RRD8.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF320. human.
GenomeRNAii162967.
PROiA2RRD8.
SOURCEiSearch...

Gene expression databases

BgeeiA2RRD8.
CleanExiHS_ZNF320.
ExpressionAtlasiA2RRD8. baseline and differential.
GenevisibleiA2RRD8. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-509.
    Tissue: Brain.
  3. "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells."
    Chernova O.B., Hunyadi A., Malaj E., Pan H., Crooks C., Roe B., Cowell J.K.
    Oncogene 20:5378-5392(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH BRWD2/WDR11.

Entry informationi

Entry nameiZN320_HUMAN
AccessioniPrimary (citable) accession number: A2RRD8
Secondary accession number(s): Q8NDR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 6, 2007
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.