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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 6

Gene

PCSK6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

SignaLinkiA2RQD9.

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 6Imported
Gene namesi
Name:PCSK6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiA2RQD9.
PeptideAtlasiA2RQD9.
PRIDEiA2RQD9.

Expressioni

Gene expression databases

BgeeiENSG00000140479.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305056.

Structurei

3D structure databases

ProteinModelPortaliA2RQD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7069S8_pro-domainInterPro annotationAdd
BLAST
Domaini117 – 356240Peptidase S8InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK08672.

Family and domain databases

Gene3Di3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2RQD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GGPAEADRVA AAHGYLNLGQ IGNLEDYYHF YHSKTFKRST LSSRGPHTFL
60 70 80 90 100
RMDPQVKWLQ QQEVKRRVKR QVRSDPQALY FNDPIWSNMW YLHCGDKNSR
110 120 130 140 150
CRSEMNVQAA WKRGYTGKNV VVTILDDGIE RNHPDLAPNY DSYASYDVNG
160 170 180 190 200
NDYDPSPRYD ASNENKHGTR CAGEVAASAN NSYCIVGIAY NAKIGGIRML
210 220 230 240 250
DGDVTDVVEA KSLGIRPNYI DIYSASWGPD DDGKTVDGPG RLAKQAFEYG
260 270 280 290 300
IKKGRQGLGS IFVWASGNGG REGDYCSCDG YTNSIYTISV SSATENGYKP
310 320 330 340 350
WYLEECASTL ATTYSSGAFY ERKIVTTDLR QRCTDGHTGT SVSAPMVAGI

IALALEA
Length:357
Mass (Da):39,414
Last modified:March 6, 2007 - v1
Checksum:i1EACBC356DCAC667
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei357 – 3571Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM491522 mRNA. Translation: CAM33226.1.
RefSeqiNP_001278238.1. NM_001291309.1.
NP_002561.1. NM_002570.4.
NP_612192.1. NM_138319.3.
NP_612195.1. NM_138322.3.
NP_612196.1. NM_138323.2.
NP_612197.1. NM_138324.2.
NP_612198.2. NM_138325.3.
UniGeneiHs.498494.
Hs.665989.

Genome annotation databases

GeneIDi5046.
KEGGihsa:5046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM491522 mRNA. Translation: CAM33226.1.
RefSeqiNP_001278238.1. NM_001291309.1.
NP_002561.1. NM_002570.4.
NP_612192.1. NM_138319.3.
NP_612195.1. NM_138322.3.
NP_612196.1. NM_138323.2.
NP_612197.1. NM_138324.2.
NP_612198.2. NM_138325.3.
UniGeneiHs.498494.
Hs.665989.

3D structure databases

ProteinModelPortaliA2RQD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305056.

Proteomic databases

PaxDbiA2RQD9.
PeptideAtlasiA2RQD9.
PRIDEiA2RQD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5046.
KEGGihsa:5046.

Organism-specific databases

CTDi5046.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK08672.

Enzyme and pathway databases

SignaLinkiA2RQD9.

Miscellaneous databases

ChiTaRSiPCSK6. human.
GenomeRNAii5046.

Gene expression databases

BgeeiENSG00000140479.

Family and domain databases

Gene3Di3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2RQD9_HUMAN
AccessioniPrimary (citable) accession number: A2RQD9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.