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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 6

Gene

PCSK6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

SignaLinkiA2RQD9.

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 6Imported
Gene namesi
Name:PCSK6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiA2RQD9.
PeptideAtlasiA2RQD9.
PRIDEiA2RQD9.

Structurei

3D structure databases

ProteinModelPortaliA2RQD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 70S8_pro-domainInterPro annotationAdd BLAST69
Domaini117 – 356Peptidase S8InterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK08672.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR036852. Peptidase_S8/S53_dom_sf.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiView protein in PROSITE
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Fragment.

A2RQD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GGPAEADRVA AAHGYLNLGQ IGNLEDYYHF YHSKTFKRST LSSRGPHTFL
60 70 80 90 100
RMDPQVKWLQ QQEVKRRVKR QVRSDPQALY FNDPIWSNMW YLHCGDKNSR
110 120 130 140 150
CRSEMNVQAA WKRGYTGKNV VVTILDDGIE RNHPDLAPNY DSYASYDVNG
160 170 180 190 200
NDYDPSPRYD ASNENKHGTR CAGEVAASAN NSYCIVGIAY NAKIGGIRML
210 220 230 240 250
DGDVTDVVEA KSLGIRPNYI DIYSASWGPD DDGKTVDGPG RLAKQAFEYG
260 270 280 290 300
IKKGRQGLGS IFVWASGNGG REGDYCSCDG YTNSIYTISV SSATENGYKP
310 320 330 340 350
WYLEECASTL ATTYSSGAFY ERKIVTTDLR QRCTDGHTGT SVSAPMVAGI

IALALEA
Length:357
Mass (Da):39,414
Last modified:March 6, 2007 - v1
Checksum:i1EACBC356DCAC667
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei357Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM491522 mRNA. Translation: CAM33226.1.
RefSeqiNP_001278238.1. NM_001291309.1.
NP_002561.1. NM_002570.4.
NP_612192.1. NM_138319.3.
NP_612195.1. NM_138322.3.
NP_612196.1. NM_138323.2.
NP_612197.1. NM_138324.2.
NP_612198.2. NM_138325.3.
UniGeneiHs.498494.
Hs.665989.

Genome annotation databases

GeneIDi5046.
KEGGihsa:5046.

Similar proteinsi

Entry informationi

Entry nameiA2RQD9_HUMAN
AccessioniPrimary (citable) accession number: A2RQD9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.