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Protein

Beta-lactamase

Gene

blaPER-2

Organism
Citrobacter freundii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaPER-2Imported
Encoded oniPlasmid pCf587Imported
OrganismiCitrobacter freundiiImported
Taxonomic identifieri546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacterCitrobacter freundii complex

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264496027 – 308Beta-lactamaseSequence analysisAdd BLAST282

Interactioni

Chemistry databases

BindingDBiA2RP81.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D2OX-ray2.20A/B25-308[»]
ProteinModelPortaliA2RP81.
SMRiA2RP81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RP81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVITKCVFT ASALLMLGLS SFVVSAQSPL LKEQIETIVT GKKATVGVAV
60 70 80 90 100
WGPDDLEPLL LNPFEKFPMQ SVFKLHLAML VLHQVDQGKL DLNQSVTVNR
110 120 130 140 150
AAVLQNTWSP MMKDHQGDEF TVAVQQLLQY SVSHSDNVAC DLLFELVGGP
160 170 180 190 200
QALHAYIQSL GVKEAAVVAN EAQMHADDQV QYQNWTSMKA AAQVLQKFEQ
210 220 230 240 250
KKQLSETSQA LLWKWMVETT TGPQRLKGLL PAGTIVAHKT GTSGVRAGKT
260 270 280 290 300
AATNDAGVIM LPDGRPLLVA VFVKDSAESE RTNEAIIAQV AQAAYQFELK

KLSAVSPD
Length:308
Mass (Da):33,453
Last modified:March 6, 2007 - v1
Checksum:i03FF5DC59416CC09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM409516 Genomic DNA. Translation: CAL64954.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM409516 Genomic DNA. Translation: CAL64954.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D2OX-ray2.20A/B25-308[»]
ProteinModelPortaliA2RP81.
SMRiA2RP81.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiA2RP81.
ChEMBLiCHEMBL5303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA2RP81_CITFR
AccessioniPrimary (citable) accession number: A2RP81
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: March 15, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.