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A2RJS3 (HEMH_LACLM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:llmg_0934
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ferrochelatase HAMAP MF_00323
PRO_1000019312

Sites

Metal binding1861Iron By similarity
Metal binding2681Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A2RJS3 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 1D40554A2C364BBF

FASTA31837,035
        10         20         30         40         50         60 
MDKKKGILLV ALGTPRSCET EDVREYLKEF LGDPLVIQKP RWLWLPILNG IILKVRPQKS 

        70         80         90        100        110        120 
AEMYKQIWTD EGSPLMSYTI AQTEQLQGLR EDFDVRFAMT YGEPRIDKVI REMKESGVED 

       130        140        150        160        170        180 
ITVLPLYPQY SLTTVEPIIQ QVKKIDDKIN VIRDFHQIES YTDLLAESIR EKWQANHYDK 

       190        200        210        220        230        240 
LILSYHGIPL SYVTKKKDAY EAQCIETTRL FVEKLGLKEE EYEHTYQSKF GPEKWLEPAT 

       250        260        270        280        290        300 
IDRIAELPKE DTKKVLICSP AFVADCLETL FELEIENKEV FVENGGETFD FVHPFNDSLE 

       310 
FTKVLSEVIE KNKVEVEV

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MG1363.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406671 Genomic DNA. Translation: CAL97528.1.
RefSeqYP_001032258.1. NC_009004.1.

3D structure databases

ProteinModelPortalA2RJS3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2RJS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4797693.
GenomeReviewsGene locus llmg_0934 in contig AM406671_GR.
KEGGllm:llmg_0934.
PATRIC22282986. VBILacLac4574_0952.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK697807.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LACLM
AccessionPrimary (citable) accession number: A2RJS3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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