Reviewed, UniProtKB/Swiss-Prot A2RJK2 (UXUA_LACLM)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	llmg_0859

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Mannonate dehydratase HAMAP MF_00106		PRO_1000034333

Sequences

	Sequence		Length	Mass (Da)
	A2RJK2-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: BB62AE6F9C95D8D7	FASTA	358	40,811
	10 20 30 40 50 60 MEMTMRWFGS NADKVELSEI AQVPGVKGVV GMIMDIPAGE VWPKERIKAL KEEIEAAGLS 70 80 90 100 110 120 LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE VICYNFMPVF DWLKSDLDYR 130 140 150 160 170 180 LADNSQTMAF VAEDIPENPQ EIIDRVQAAD GGFSLPGWEP ERLSEVKDLF EAYKNVDEHK 190 200 210 220 230 240 LRENFAYFLK AIIPTCEEVG IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA 250 260 270 280 290 300 ITLCTGSIAE DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGEKDFYEA PHMSEYGSLD 310 320 330 340 350 MYKILKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW EALEKNKQ

References

[1]

"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM406671 Genomic DNA. Translation: CAL97454.1.
RefSeq	YP_001032187.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2RJK2.
Genome annotation databases
GeneID	4797290.
GenomeReviews	Gene locus llmg_0859 in contig AM406671_GR.
KEGG	llm:llmg_0859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IWGETGR.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_LACLM

Accession

Primary (citable) accession number: A2RJK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 6, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)