Reviewed, UniProtKB/Swiss-Prot A2RJD1 (AROD_LACLM)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	llmg_0782

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000043167
Sites
	Active site	121	1	Proton acceptor By similarity
	Active site	146	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2RJD1-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 935B5537DE78C808	FASTA	229	26,309
	10 20 30 40 50 60 MRRTKIVVPI MLTELTELEK VSVSDYHSAD IVEWRADFLS ADDIFEMAPK FFEKFKESKI 70 80 90 100 110 120 LFTLRTVREG GNIQVSEKKY LQILQEILKF DPDYIDVEYF SHGPSFAALK NYREKIVLSY 130 140 150 160 170 180 HNFDEVPTDL TSRLIKMHEE GTAFVKVAVM PERECDVLDL LQITRDMTLE YGNHFISMAM 190 200 210 220 GDLGRLSRIS GYLTGSCWTF ASLENSSAPG QISLKETVEI LDLLENELA

References

[1]

"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM406671 Genomic DNA. Translation: CAL97383.1.
RefSeq	YP_001032116.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2RJD1.
Genome annotation databases
GeneID	4798537.
GenomeReviews	Gene locus llmg_0782 in contig AM406671_GR.
KEGG	llm:llmg_0782.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MSNHDFD.
Family and domain databases
HAMAP	MF_00214. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
ProDom	PD005337. DHquinase_I. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01093. aroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_LACLM

Accession

Primary (citable) accession number: A2RJD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 6, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)