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A2RIZ1 (A2RIZ1_LACLM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icd EMBL CAL97239.1
Ordered Locus Names:llmg_0637
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP] EMBL CAL97239.1
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus ›

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
A2RIZ1 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 0BFC270CD67AFFAD

FASTA41245,612
        10         20         30         40         50         60 
MKIEMKNGKL IVPDYPTIGY IRGDGVGEDI FPQAKRVFDA AVLKIFGEKK KIDWQKLLAG 

        70         80         90        100        110        120 
GEAFASRGEY LPDETLEQIK ENLIAIKGPL MTPVGESFRS INVTLRQKLD LYACVRPVEY 

       130        140        150        160        170        180 
FTGIKSPVRA PEKVNMTIFR ENTEDIYAGI EFSSSSKESK KLINFLEREL SVHSIRFPET 

       190        200        210        220        230        240 
SAIGIKPVSP DGSKRLVSAA FDYAIKMNKK RVTFVHKGNI MKFTEGGFRK WGYEVAKNYP 

       250        260        270        280        290        300 
TFTKLEYDKI KEEKGTEQSE KEKNIALKSG KIYVDDAIAD NFLQQIILNP DNFEVVATLN 

       310        320        330        340        350        360 
LNGDYISDAL AAQVGGIGIA PGANINYESG HAIFEATHGT APDIAGKNIA NPSSLILSGV 

       370        380        390        400        410 
MMFEYLGWQE VAELIKIALS ASFHSGALTA DLGGKLSTSE FTDTLVQYIK NY

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References

[1]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MG1363.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406671 Genomic DNA. Translation: CAL97239.1.
RefSeqYP_001031980.1. NC_009004.1.

3D structure databases

ProteinModelPortalA2RIZ1.
SMRA2RIZ1. Positions 2-409.
ModBaseSearch...

Protein-protein interaction databases

STRING416870.llmg_0637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL97239; CAL97239; llmg_0637.
GeneID4796910.
KEGGllm:llmg_0637.
PATRIC22282374. VBILacLac4574_0652.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000021113.
KOK00031.
OMAFRDWGYE.
ProtClustDBCLSK697344.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2RIZ1_LACLM
AccessionPrimary (citable) accession number: A2RIZ1
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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