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A2RHZ5

- ACMA_LACLM

UniProt

A2RHZ5 - ACMA_LACLM

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Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes the cell wall of L.lactis and M.lysodeikticus. Required for cell separation during growth.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. amidase activity Source: InterPro
  2. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cell wall organization Source: UniProtKB-KW
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-291-MONOMER.

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH73. Glycoside Hydrolase Family 73.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramidase (EC:3.2.1.17)
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene namesi
Name:acmA
Ordered Locus Names:llmg_0280
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000364: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5757Sequence AnalysisAdd
BLAST
Chaini58 – 437380Probable N-acetylmuramidasePRO_0000285234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416870.llmg_0280.

Structurei

3D structure databases

ProteinModelPortaliA2RHZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati245 – 28743LysM 1Add
BLAST
Repeati321 – 36343LysM 2Add
BLAST
Repeati395 – 43743LysM 3Add
BLAST

Domaini

The LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 3 LysM repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG1388.
HOGENOMiHOG000033783.
OMAiKAWRANA.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR018392. LysM_dom.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view]
PfamiPF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RHZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSRVKVKN RHLKKKTKKP LAFYKPATKF AGAVLIAGTL TTTHELLLQQ
60 70 80 90 100
TSPMVQAATN SSEVFIESIA ASAKPVADAN GLYPSVMIAQ AILESNWGSS
110 120 130 140 150
QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS
160 170 180 190 200
FQDNAYVLKT TNFGNGPYYA KAWRANAATY QDATAALTGR YATDPSYGAS
210 220 230 240 250
LNRIISQYNL TRFDGASSAG NTNSGGSTTT ITNNNSGTNS SSTTYTVKSG
260 270 280 290 300
DTLWGISQRY GISVAQIQSA NNLKSTIIYI GQKLVLTGSA SSTNSGGSNN
310 320 330 340 350
SASTTPTTSV TPAKPTSQTT VKVKSGDTLW ALSVKYKTSI AQLKSWNHLS
360 370 380 390 400
SDTIYIGQNL IVSQSAAASN PSTGSGSTAT NNSNSTSSNS NASIHKVVKG
410 420 430
DTLWGLSQKS GSPIASIKAW NHLSSDTILI GQYLRIK
Length:437
Mass (Da):46,564
Last modified:March 6, 2007 - v1
Checksum:i5C905633BD5DE28B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17696 Genomic DNA. Translation: AAC33367.1.
AM406671 Genomic DNA. Translation: CAL96887.1.
RefSeqiYP_001031636.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL96887; CAL96887; llmg_0280.
GeneIDi4797197.
KEGGillm:llmg_0280.
PATRICi22281590. VBILacLac4574_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17696 Genomic DNA. Translation: AAC33367.1 .
AM406671 Genomic DNA. Translation: CAL96887.1 .
RefSeqi YP_001031636.1. NC_009004.1.

3D structure databases

ProteinModelPortali A2RHZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416870.llmg_0280.

Protein family/group databases

CAZyi CBM50. Carbohydrate-Binding Module Family 50.
GH73. Glycoside Hydrolase Family 73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL96887 ; CAL96887 ; llmg_0280 .
GeneIDi 4797197.
KEGGi llm:llmg_0280.
PATRICi 22281590. VBILacLac4574_0287.

Phylogenomic databases

eggNOGi COG1388.
HOGENOMi HOG000033783.
OMAi KAWRANA.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci LLAC416870:GCDT-291-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR018392. LysM_dom.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view ]
Pfami PF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence of the gene encoding the major peptidoglycan hydrolase of Lactococcus lactis, a muramidase needed for cell separation."
    Buist G., Kok J., Leenhouts K.J., Dabrowska M., Venema G., Haandrikman A.J.
    J. Bacteriol. 177:1554-1563(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
    Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
    J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MG1363.

Entry informationi

Entry nameiACMA_LACLM
AccessioniPrimary (citable) accession number: A2RHZ5
Secondary accession number(s): O52362, Q48603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3