A2RH97 (MTLD_LACLM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	llmg_0025

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011803
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2RH97 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 62FFBF96706C9C6F	FASTA	388	43,946
	10 20 30 40 50 60 MKKAVHFGAG NIGRGFIGEI LSKNGFEIYF VDTNKAIIDE LNTRHSYEIG IASSSPEKIS 70 80 90 100 110 120 VSGVFGINNG ENPKDVIEAI AQADIVTTAI GPNILPYIAE LVAKGIQKRK EENKQVQIDI 130 140 150 160 170 180 IACENMIGGS EFLEKKVAEY LSDSDKVYLA NYIGFPNAAV DRIVPGQKHE DLLYVEVEPF 190 200 210 220 230 240 CEWVIDESQI KNKSFKLEGV HYASNLEPFI ERKLFSVNSG HATVAYSSAY KGYKTILEGL 250 260 270 280 290 300 QHKEILSALK GVQKETRALL LAKWPQYFTE EDLMSYHQMI ISRFANPKII DEVTRVARTP 310 320 330 340 350 360 IRKLGYDERF IRPIRELNER GLSYQNHLDI VGKIFAYQDE NDSQSVQLQE KLSTMDFQRL 370 380 IEEVTGLSNK KIILEIELVI KKYKNDSK

References

[1]

"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MG1363.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM406671 Genomic DNA. Translation: CAL96633.1.
RefSeq	YP_001031389.1. NC_009004.1.
3D structure databases
ProteinModelPortal	A2RH97.
ModBase	Search...
Protein-protein interaction databases
STRING	A2RH97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4797451.
GenomeReviews	Gene locus llmg_0025 in contig AM406671_GR.
KEGG	llm:llmg_0025.
PATRIC	22281052. VBILacLac4574_0024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG568825.
OMA	FANTAVD.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACLM

Accession

Primary (citable) accession number: A2RH97

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 6, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program