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A2RH97 (MTLD_LACLM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase

EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:llmg_0025
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011803

Regions

Nucleotide binding4 – 1512NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A2RH97 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 62FFBF96706C9C6F

FASTA38843,946
        10         20         30         40         50         60 
MKKAVHFGAG NIGRGFIGEI LSKNGFEIYF VDTNKAIIDE LNTRHSYEIG IASSSPEKIS 

        70         80         90        100        110        120 
VSGVFGINNG ENPKDVIEAI AQADIVTTAI GPNILPYIAE LVAKGIQKRK EENKQVQIDI 

       130        140        150        160        170        180 
IACENMIGGS EFLEKKVAEY LSDSDKVYLA NYIGFPNAAV DRIVPGQKHE DLLYVEVEPF 

       190        200        210        220        230        240 
CEWVIDESQI KNKSFKLEGV HYASNLEPFI ERKLFSVNSG HATVAYSSAY KGYKTILEGL 

       250        260        270        280        290        300 
QHKEILSALK GVQKETRALL LAKWPQYFTE EDLMSYHQMI ISRFANPKII DEVTRVARTP 

       310        320        330        340        350        360 
IRKLGYDERF IRPIRELNER GLSYQNHLDI VGKIFAYQDE NDSQSVQLQE KLSTMDFQRL 

       370        380 
IEEVTGLSNK KIILEIELVI KKYKNDSK 

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References

[1]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MG1363.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM406671 Genomic DNA. Translation: CAL96633.1.
RefSeqYP_001031389.1. NC_009004.1.

3D structure databases

ProteinModelPortalA2RH97.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2RH97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4797451.
GenomeReviewsGene locus llmg_0025 in contig AM406671_GR.
KEGGllm:llmg_0025.
PATRIC22281052. VBILacLac4574_0024.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBPRK02318.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_LACLM
AccessionPrimary (citable) accession number: A2RH97
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families