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A2RGS2

- FTHS2_STRPG

UniProt

A2RGS2 - FTHS2_STRPG

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Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-1798-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Ordered Locus Names:SpyM51732
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligase 2PRO_0000293068Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160491.SpyM51732.

Structurei

3D structure databases

ProteinModelPortaliA2RGS2.
SMRiA2RGS2. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RGS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSDIEIAN SVTMEPISKV ADQLGIDKEA LCLYGKYKAK IDARQLVALK
60 70 80 90 100
DKPDGKLILV TAISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG
110 120 130 140 150
PVFGVKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH
160 170 180 190 200
HGNSLGIDSR RITWKRVVDM NDRQLRHIVD GLQGKVNGVP REDGYDITVA
210 220 230 240 250
SEIMAILCLS ENISDLKARL EKIIIGYNFQ GEPVTAKDLK AGGALAALLK
260 270 280 290 300
DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA
310 320 330 340 350
GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VPKADLATEN
360 370 380 390 400
VQAVVDGLPN LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACDK
410 420 430 440 450
RGVDVVISDV WANGGAGGRE LAEKVVALAE QDNQFRFVYE EDDSIETKLT
460 470 480 490 500
KIVTKVYGGK GIKLTPTAKR ELAELERLGF GNYPICMAKT QYSFSDDAKK
510 520 530 540 550
LGAPTDFIVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP ASETIDIDEE

GNITGLF
Length:557
Mass (Da):59,089
Last modified:March 6, 2007 - v1
Checksum:i40465A698EF365DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM31054.1.
RefSeqiWP_011889210.1. NC_009332.1.
YP_001129248.1. NC_009332.1.

Genome annotation databases

GeneIDi4963886.
KEGGispf:SpyM51732.
PATRICi19766748. VBIStrPyo41547_1818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM31054.1 .
RefSeqi WP_011889210.1. NC_009332.1.
YP_001129248.1. NC_009332.1.

3D structure databases

ProteinModelPortali A2RGS2.
SMRi A2RGS2. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160491.SpyM51732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4963886.
KEGGi spf:SpyM51732.
PATRICi 19766748. VBIStrPyo41547_1818.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPYO160491:GJ8O-1798-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiFTHS2_STRPG
AccessioniPrimary (citable) accession number: A2RGS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3