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A2RGH2

- PNP_STRPG

UniProt

A2RGH2 - PNP_STRPG

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891MagnesiumUniRule annotation
Metal bindingi495 – 4951MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-1696-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:SpyM51633
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Polyribonucleotide nucleotidyltransferasePRO_0000329880Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160491.SpyM51633.

Structurei

3D structure databases

ProteinModelPortaliA2RGH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61560KHUniRule annotationAdd
BLAST
Domaini625 – 69369S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiINTENDG.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RGH2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQTFTTTF AGKPLVVEVG QVAKQANGAT VVRYGDSTVL TAAVMSKKMA
60 70 80 90 100
TGDFFPLQVN YEEKMYAAGK FPGGFMKREG RPSTDATLTA RLIDRPIRPM
110 120 130 140 150
FAEGFRNEVQ VINTVLSYDE NASAPVAAMF GSSLALSISD IPFNGPIAGV
160 170 180 190 200
QVGYIDGEFI INPDKEQMEA SLLELTVAGS KEAINMVESG AKELSEDIML
210 220 230 240 250
EALLKGHQAI QELIAFQEQI VAVVGKEKAE VELLQVDADL QADIVAKYNV
260 270 280 290 300
QLQKAVQVEE KKAREAATEA VKEMVKAEYE ERYVEDENLA TIMRDVAEIL
310 320 330 340 350
EQMEHAEVRR LITEDKIRPD GRKIDEIRPL DAVVDFLPKV HGSGLFTRGQ
360 370 380 390 400
TQALSVLTLA PMGETQIIDG LAPEYKKRFL HHYNFPQYSV GETGRYGAAG
410 420 430 440 450
RREIGHGALG ERALEQVLPS LEEFPYAIRL VAEVLESNGS SSQASICAGT
460 470 480 490 500
LALMAGGVPI KAPVAGIAMG LISDGTNYTV LTDIQGLEDH FGDMDFKVAG
510 520 530 540 550
TREGITALQM DIKIAGITPQ ILEEALAQAK KARFEILDVI EATIAEPHPE
560 570 580 590 600
LAPTAPKIDT IKIDVDKIKV VIGKGGETID KIIAETGVKI DIDDEGNVSI
610 620 630 640 650
YSSDQAAIDR TKEIIAGLVR EAKVGEVYHA KVIRIEKFGA FVNLFDKTDA
660 670 680 690 700
LVHISEIAWT RTANVSDVLE VGEDVDVKVI KIDEKGRVDA SMKALIPRPP
710
KPEKKEEKHD
Length:710
Mass (Da):77,358
Last modified:March 6, 2007 - v1
Checksum:i6647AA5FA58382E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30954.1.
RefSeqiWP_011889159.1. NC_009332.1.
YP_001129152.1. NC_009332.1.

Genome annotation databases

GeneIDi4963828.
KEGGispf:SpyM51633.
PATRICi19766526. VBIStrPyo41547_1709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30954.1 .
RefSeqi WP_011889159.1. NC_009332.1.
YP_001129152.1. NC_009332.1.

3D structure databases

ProteinModelPortali A2RGH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160491.SpyM51633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4963828.
KEGGi spf:SpyM51633.
PATRICi 19766526. VBIStrPyo41547_1709.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi INTENDG.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SPYO160491:GJ8O-1696-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiPNP_STRPG
AccessioniPrimary (citable) accession number: A2RGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3