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A2RFQ7

- CAPP_STRPG

UniProt

A2RFQ7 - CAPP_STRPG

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, SpyM51358
Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381 By similarity
Active sitei583 – 5831 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-1417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:SpyM51358
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_1000025594Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160491.SpyM51358.

Structurei

3D structure databases

ProteinModelPortaliA2RFQ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiSILNCET.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RFQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MPLKKLESSN NQAIIAEEVA LLKEMLENIT RRMIGDDAFT VIESIMVLSE    50
KQDYIELEKV VANISNQEME VISRYFSILP LLINISEDVD LAYEINYQNN 100
TDTDYLGKLA LTIKDLAGKD NGKDILEQVN VVPVLTAHPT QVQRKTILEL 150
TTHIHKLLRK YRDAKAGVIS LEKWRQELYR YIEMIMQTDI IREKKLQVKN 200
EIKNVMQYYD GSLIQAVTKL TTEYKNLAQK HGLELDNPKP ITMGMWIGGD 250
RDGNPFVTAE TLCLSATVQS EVILNYYIDK LAALYRTFSL SSTLVQPNSE 300
VERLASLSQD QSIYRGNEPY RRAFHYIQSR LKQTQIQLTN QPAARMSSSV 350
GLSTSAWSSP ASLENPILAY DSPVDFKADL KAIEQSLLDN GNSALIEGDL 400
REVMQAVDIF GFFLASIDMR QDSSVQEACV AELLKGANIV DDYSSLSETE 450
KCDVLVQQLM EEPRTLSSAA VAKSDLLEKE LAIYTTAREL KDKLGEEVIK 500
QHIISHTESV SDMFELAIML KEVGLVDQQR ARVQIVPLFE TIEDLDNARD 550
IMAAYLSHDI VKSWIATNRN YQEIMLGYSD SNKDGGYLAS GWTLYKAQNE 600
LTAIGEEHGV KITFFHGRGG TVGRGGGPSY DAITSQPFGS IKDRIRLTEQ 650
GEIIENKYGN KDVAYYHLEM LISASINRMV TQMITDPNEI DSFREIMDSI 700
VADSNIIYRK LVFDNPHFYD YFFEASPIKE VSSLNIGSRP AARKTITEIT 750
GLRAIPWVFS WSQNRIMFPG WYGVGSAFKR YIDRAQGNLE RLQHMYQTWP 800
FFHSLLSNVD MVLSKSNMNI AFQYAQLAES QDVRDVFYEI LDEWQLTKNV 850
ILAIQDHDDL LEDNPSLKHS LKSRLPYFNV LNYIQIELIK RWRNNQLDEN 900
DEKLIHTTIN GIATGLRNSG 920
Length:920
Mass (Da):104,639
Last modified:March 6, 2007 - v1
Checksum:iF1297FA8B6ECA601
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30686.1.
RefSeqiYP_001128899.1. NC_009332.1.

Genome annotation databases

GeneIDi4964166.
KEGGispf:SpyM51358.
PATRICi19765922. VBIStrPyo41547_1412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30686.1 .
RefSeqi YP_001128899.1. NC_009332.1.

3D structure databases

ProteinModelPortali A2RFQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160491.SpyM51358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4964166.
KEGGi spf:SpyM51358.
PATRICi 19765922. VBIStrPyo41547_1412.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi SILNCET.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci SPYO160491:GJ8O-1417-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiCAPP_STRPG
AccessioniPrimary (citable) accession number: A2RFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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