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Protein

Shikimate kinase

Gene

aroK

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141MagnesiumUniRule annotation
Binding sitei28 – 281SubstrateUniRule annotation
Binding sitei52 – 521SubstrateUniRule annotation
Binding sitei75 – 751Substrate; via amide nitrogenUniRule annotation
Binding sitei116 – 1161ATPUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei151 – 1511ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-813-MONOMER.
UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:SpyM50759
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Shikimate kinasePRO_1000094423Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi160491.SpyM50759.

Structurei

3D structure databases

ProteinModelPortaliA2RE14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032569.
KOiK00891.
OMAiRMALYEG.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RE14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVLLGFMG VGKTTVSKHL SMHCKDMDAI IEAKIGMSIA AFFEQHGEIA
60 70 80 90 100
FRTIENQVLK DLLFANDNSV IVTGGGVVVL QENRQLLRKN HQHNILLVAS
110 120 130 140 150
FETLYQRLKH DKKSQRPLFL KYSKEAFYEF YQQRMVFYEG LSDLVIRVDH
160
RTPEEVANII EGY
Length:163
Mass (Da):18,779
Last modified:March 5, 2007 - v1
Checksum:i7DDF0E3EC6BBB49C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM30089.1.
RefSeqiYP_001128323.1. NC_009332.1.

Genome annotation databases

KEGGispf:SpyM50759.
PATRICi19764676. VBIStrPyo41547_0793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM30089.1.
RefSeqiYP_001128323.1. NC_009332.1.

3D structure databases

ProteinModelPortaliA2RE14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160491.SpyM50759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGispf:SpyM50759.
PATRICi19764676. VBIStrPyo41547_0793.

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032569.
KOiK00891.
OMAiRMALYEG.
OrthoDBiEOG6SJJGD.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.
BioCyciSPYO160491:GJ8O-813-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiAROK_STRPG
AccessioniPrimary (citable) accession number: A2RE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2009
Last sequence update: March 5, 2007
Last modified: March 31, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.