SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2RE14

- AROK_STRPG

UniProt

A2RE14 - AROK_STRPG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Shikimate kinase
Gene
aroK, SpyM50759
Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Magnesium By similarity
Binding sitei28 – 281Substrate By similarity
Binding sitei52 – 521Substrate By similarity
Binding sitei75 – 751Substrate; via amide nitrogen By similarity
Binding sitei116 – 1161ATP By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei151 – 1511ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-813-MONOMER.
UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinase (EC:2.7.1.71)
Short name:
SK
Gene namesi
Name:aroK
Ordered Locus Names:SpyM50759
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Shikimate kinaseUniRule annotation
PRO_1000094423Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi160491.SpyM50759.

Structurei

3D structure databases

ProteinModelPortaliA2RE14.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032569.
KOiK00891.
OMAiINVEHRT.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RE14-1 [UniParc]FASTAAdd to Basket

« Hide

MTKVLLGFMG VGKTTVSKHL SMHCKDMDAI IEAKIGMSIA AFFEQHGEIA    50
FRTIENQVLK DLLFANDNSV IVTGGGVVVL QENRQLLRKN HQHNILLVAS 100
FETLYQRLKH DKKSQRPLFL KYSKEAFYEF YQQRMVFYEG LSDLVIRVDH 150
RTPEEVANII EGY 163
Length:163
Mass (Da):18,779
Last modified:March 6, 2007 - v1
Checksum:i7DDF0E3EC6BBB49C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30089.1.
RefSeqiYP_001128323.1. NC_009332.1.

Genome annotation databases

GeneIDi4963255.
KEGGispf:SpyM50759.
PATRICi19764676. VBIStrPyo41547_0793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM30089.1 .
RefSeqi YP_001128323.1. NC_009332.1.

3D structure databases

ProteinModelPortali A2RE14.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160491.SpyM50759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4963255.
KEGGi spf:SpyM50759.
PATRICi 19764676. VBIStrPyo41547_0793.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032569.
KOi K00891.
OMAi INVEHRT.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .
BioCyci SPYO160491:GJ8O-813-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiAROK_STRPG
AccessioniPrimary (citable) accession number: A2RE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi