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A2RE14 (AROK_STRPG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate kinase
Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:SpyM50759
OrganismStreptococcus pyogenes serotype M5 (strain Manfredo) [Complete proteome] [HAMAP]
Taxonomic identifier160491 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP-Rule MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP-Rule MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP-Rule MF_00109

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the shikimate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Shikimate kinase HAMAP-Rule MF_00109
PRO_1000094423

Regions

Nucleotide binding10 – 156ATP By similarity

Sites

Metal binding141Magnesium By similarity
Binding site281Substrate By similarity
Binding site521Substrate By similarity
Binding site751Substrate; via amide nitrogen By similarity
Binding site1161ATP By similarity
Binding site1341Substrate By similarity
Binding site1511ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2RE14 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 7DDF0E3EC6BBB49C

FASTA16318,779
        10         20         30         40         50         60 
MTKVLLGFMG VGKTTVSKHL SMHCKDMDAI IEAKIGMSIA AFFEQHGEIA FRTIENQVLK 

        70         80         90        100        110        120 
DLLFANDNSV IVTGGGVVVL QENRQLLRKN HQHNILLVAS FETLYQRLKH DKKSQRPLFL 

       130        140        150        160 
KYSKEAFYEF YQQRMVFYEG LSDLVIRVDH RTPEEVANII EGY

« Hide

References

[1]"Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain Manfredo."
Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S., Skelton J. expand/collapse author list , Whitehead S., Barrell B.G., Kehoe M., Parkhill J.
J. Bacteriol. 189:1473-1477(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Manfredo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM295007 Genomic DNA. Translation: CAM30089.1.
RefSeqYP_001128323.1. NC_009332.1.

3D structure databases

ProteinModelPortalA2RE14.
ModBaseSearch...

Protein-protein interaction databases

STRING160491.SpyM50759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4963255.
KEGGspf:SpyM50759.
PATRIC19764676. VBIStrPyo41547_0793.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0703.
HOGENOMHOG000032569.
KOK00891.
OMAIEMPIAT.
ProtClustDBPRK00131.

Enzyme and pathway databases

UniPathwayUPA00053; UER00088.

Family and domain databases

HAMAPMF_00109. Shikimate_kinase.
InterProIPR000623. Shikimate_kinase.
[Graphical view]
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
PROSITEPS01128. SHIKIMATE_KINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROK_STRPG
AccessionPrimary (citable) accession number: A2RE14
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 6, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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