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A2RE14

- AROK_STRPG

UniProt

A2RE14 - AROK_STRPG

Protein

Shikimate kinase

Gene

aroK

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

    Catalytic activityi

    ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141MagnesiumUniRule annotation
    Binding sitei28 – 281SubstrateUniRule annotation
    Binding sitei52 – 521SubstrateUniRule annotation
    Binding sitei75 – 751Substrate; via amide nitrogenUniRule annotation
    Binding sitei116 – 1161ATPUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Binding sitei151 – 1511ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. shikimate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO160491:GJ8O-813-MONOMER.
    UniPathwayiUPA00053; UER00088.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
    Short name:
    SKUniRule annotation
    Gene namesi
    Name:aroKUniRule annotation
    Ordered Locus Names:SpyM50759
    OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
    Taxonomic identifieri160491 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002591: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Shikimate kinasePRO_1000094423Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi160491.SpyM50759.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RE14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000032569.
    KOiK00891.
    OMAiINVEHRT.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2RE14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVLLGFMG VGKTTVSKHL SMHCKDMDAI IEAKIGMSIA AFFEQHGEIA    50
    FRTIENQVLK DLLFANDNSV IVTGGGVVVL QENRQLLRKN HQHNILLVAS 100
    FETLYQRLKH DKKSQRPLFL KYSKEAFYEF YQQRMVFYEG LSDLVIRVDH 150
    RTPEEVANII EGY 163
    Length:163
    Mass (Da):18,779
    Last modified:March 6, 2007 - v1
    Checksum:i7DDF0E3EC6BBB49C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295007 Genomic DNA. Translation: CAM30089.1.
    RefSeqiYP_001128323.1. NC_009332.1.

    Genome annotation databases

    GeneIDi4963255.
    KEGGispf:SpyM50759.
    PATRICi19764676. VBIStrPyo41547_0793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295007 Genomic DNA. Translation: CAM30089.1 .
    RefSeqi YP_001128323.1. NC_009332.1.

    3D structure databases

    ProteinModelPortali A2RE14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160491.SpyM50759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4963255.
    KEGGi spf:SpyM50759.
    PATRICi 19764676. VBIStrPyo41547_0793.

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000032569.
    KOi K00891.
    OMAi INVEHRT.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00088 .
    BioCyci SPYO160491:GJ8O-813-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Manfredo.

    Entry informationi

    Entry nameiAROK_STRPG
    AccessioniPrimary (citable) accession number: A2RE14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3