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Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C

Gene

gatC

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation
ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit CUniRule annotation (EC:6.3.5.-UniRule annotation)
Short name:
Asp/Glu-ADT subunit CUniRule annotation
Gene namesi
Name:gatCUniRule annotation
Ordered Locus Names:SpyM50337
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit CPRO_1000016222Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2RCV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GatC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0721.
HOGENOMiHOG000017523.
KOiK02435.
OMAiKKNIMRA.
OrthoDBiEOG61S35Z.

Family and domain databases

HAMAPiMF_00122. GatC.
InterProiIPR003837. Asp/Glu-ADT_csu.
[Graphical view]
PfamiPF02686. Glu-tRNAGln. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00135. gatC. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RCV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISEEEVRH VAKLSKLSFS ESETTTFATT LSKIVDMVEL LNEVDTEGVA
60 70 80 90 100
ITTTMADKKN VMRQDVAEEG TDRALLFKNV PEKENHFIKV PAILDDGGDA
Length:100
Mass (Da):11,070
Last modified:March 6, 2007 - v1
Checksum:iBA29B5EA64C911EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM29679.1.
RefSeqiWP_002988561.1. NC_009332.1.

Genome annotation databases

GeneIDi13902479.
KEGGispf:SpyM50337.
PATRICi19763788. VBIStrPyo41547_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM29679.1.
RefSeqiWP_002988561.1. NC_009332.1.

3D structure databases

ProteinModelPortaliA2RCV6.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiA2RCV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13902479.
KEGGispf:SpyM50337.
PATRICi19763788. VBIStrPyo41547_0362.

Phylogenomic databases

eggNOGiCOG0721.
HOGENOMiHOG000017523.
KOiK02435.
OMAiKKNIMRA.
OrthoDBiEOG61S35Z.

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-390-MONOMER.

Family and domain databases

HAMAPiMF_00122. GatC.
InterProiIPR003837. Asp/Glu-ADT_csu.
[Graphical view]
PfamiPF02686. Glu-tRNAGln. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00135. gatC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiGATC_STRPG
AccessioniPrimary (citable) accession number: A2RCV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: July 22, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.