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A2RCV6

- GATC_STRPG

UniProt

A2RCV6 - GATC_STRPG

Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C

Gene

gatC

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation
    ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of translational fidelity Source: InterPro
    2. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO160491:GJ8O-390-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit CUniRule annotation (EC:6.3.5.-UniRule annotation)
    Short name:
    Asp/Glu-ADT subunit CUniRule annotation
    Gene namesi
    Name:gatCUniRule annotation
    Ordered Locus Names:SpyM50337
    OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
    Taxonomic identifieri160491 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002591: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100100Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit CPRO_1000016222Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi160491.SpyM50337.

    Structurei

    3D structure databases

    ProteinModelPortaliA2RCV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GatC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0721.
    HOGENOMiHOG000017523.
    KOiK02435.
    OMAiQNVPEKE.
    OrthoDBiEOG61S35Z.

    Family and domain databases

    HAMAPiMF_00122. GatC.
    InterProiIPR003837. Asp/Glu-ADT_csu.
    [Graphical view]
    PfamiPF02686. Glu-tRNAGln. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00135. gatC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2RCV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISEEEVRH VAKLSKLSFS ESETTTFATT LSKIVDMVEL LNEVDTEGVA    50
    ITTTMADKKN VMRQDVAEEG TDRALLFKNV PEKENHFIKV PAILDDGGDA 100
    Length:100
    Mass (Da):11,070
    Last modified:March 6, 2007 - v1
    Checksum:iBA29B5EA64C911EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295007 Genomic DNA. Translation: CAM29679.1.
    RefSeqiYP_001127927.1. NC_009332.1.

    Genome annotation databases

    GeneIDi4962959.
    KEGGispf:SpyM50337.
    PATRICi19763788. VBIStrPyo41547_0362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM295007 Genomic DNA. Translation: CAM29679.1 .
    RefSeqi YP_001127927.1. NC_009332.1.

    3D structure databases

    ProteinModelPortali A2RCV6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160491.SpyM50337.

    Chemistry

    BindingDBi A2RCV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4962959.
    KEGGi spf:SpyM50337.
    PATRICi 19763788. VBIStrPyo41547_0362.

    Phylogenomic databases

    eggNOGi COG0721.
    HOGENOMi HOG000017523.
    KOi K02435.
    OMAi QNVPEKE.
    OrthoDBi EOG61S35Z.

    Enzyme and pathway databases

    BioCyci SPYO160491:GJ8O-390-MONOMER.

    Family and domain databases

    HAMAPi MF_00122. GatC.
    InterProi IPR003837. Asp/Glu-ADT_csu.
    [Graphical view ]
    Pfami PF02686. Glu-tRNAGln. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00135. gatC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Manfredo.

    Entry informationi

    Entry nameiGATC_STRPG
    AccessioniPrimary (citable) accession number: A2RCV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3