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A2RCV6 (GATC_STRPG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C

Short name=Asp/Glu-ADT subunit C
EC=6.3.5.-
Gene names
Name:gatC
Ordered Locus Names:SpyM50337
OrganismStreptococcus pyogenes serotype M5 (strain Manfredo) [Complete proteome] [HAMAP]
Taxonomic identifier160491 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) By similarity. HAMAP-Rule MF_00122

Catalytic activity

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. HAMAP-Rule MF_00122

ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate. HAMAP-Rule MF_00122

Subunit structure

Heterotrimer of A, B and C subunits By similarity. HAMAP-Rule MF_00122

Sequence similarities

Belongs to the GatC family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of translational fidelity

Inferred from electronic annotation. Source: InterPro

translation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C HAMAP-Rule MF_00122
PRO_1000016222

Sequences

Sequence LengthMass (Da)Tools
A2RCV6 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: BA29B5EA64C911EB

FASTA10011,070
        10         20         30         40         50         60 
MKISEEEVRH VAKLSKLSFS ESETTTFATT LSKIVDMVEL LNEVDTEGVA ITTTMADKKN 

        70         80         90        100 
VMRQDVAEEG TDRALLFKNV PEKENHFIKV PAILDDGGDA 

« Hide

References

[1]"Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain Manfredo."
Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S., Skelton J. expand/collapse author list , Whitehead S., Barrell B.G., Kehoe M., Parkhill J.
J. Bacteriol. 189:1473-1477(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Manfredo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM295007 Genomic DNA. Translation: CAM29679.1.
RefSeqYP_001127927.1. NC_009332.1.

3D structure databases

ProteinModelPortalA2RCV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160491.SpyM50337.

Chemistry

BindingDBA2RCV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4962959.
KEGGspf:SpyM50337.
PATRIC19763788. VBIStrPyo41547_0362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0721.
HOGENOMHOG000017523.
KOK02435.
OMAQNVPEKE.
OrthoDBEOG61S35Z.
ProtClustDBPRK00034.

Enzyme and pathway databases

BioCycSPYO160491:GJ8O-390-MONOMER.

Family and domain databases

HAMAPMF_00122. GatC.
InterProIPR003837. Asp/Glu-ADT_csu.
[Graphical view]
PfamPF02686. Glu-tRNAGln. 1 hit.
[Graphical view]
TIGRFAMsTIGR00135. gatC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGATC_STRPG
AccessionPrimary (citable) accession number: A2RCV6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families