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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:SpyM50081
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11881188DNA-directed RNA polymerase subunit betaPRO_0000300413Add
BLAST

Proteomic databases

PRIDEiA2RC51.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2RC51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2RC51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHEVRYGK HRTRRSFSRI KEVLDLPNLI EIQTDSFQDF LDSGLKEVFE
60 70 80 90 100
DVLPISNFTD TMELEFVGYE FKEPKYTLEE ARIHDASYSA PIFVTFRLVN
110 120 130 140 150
KETGEIKTQE VFFGDFPIMT EMGTFIINGG ERIIVSQLVR SPGVYFNDKV
160 170 180 190 200
DKNGKVGYGS TVIPNRGAWL ELETDSKDIA YTRIDRTRKI PFTTLVRALG
210 220 230 240 250
FSGDDEIVDI FGESDLVRNT IEKDIHKNPS DSRTDEALKE IYERLRPGEP
260 270 280 290 300
KTADSSRSLL IARFFDARRY DLAAVGRYKV NKKLNIKTRL LNQIIAENLV
310 320 330 340 350
DAETGEILVE AGTEMTRSVI ESIEEHLDGD LNKFVYTPND YAVVTEPVVL
360 370 380 390 400
QKFKVVSPID PDRVVTIVGN ANPDDKVRAL TPADILAEMS YFLNLAEGLG
410 420 430 440 450
KVDDIDHLGN RRIRAVGELL ANQFRIGLAR MERNVRERMS VQDNDVLTPQ
460 470 480 490 500
QIINIRPVTA AVKEFFGSSQ LSQFMDQHNP LSELSHKRRL SALGPGGLTR
510 520 530 540 550
DRAGYEVRDV HYTHYGRMCP IETPEGPNIG LINNLSSFGH LNKYGFIQTP
560 570 580 590 600
YRKVDRATGR VTNEIVWLTA DEEDEYTVAQ ANSKLNEDGT FAEEIVMGRH
610 620 630 640 650
QGNNQEFSAS VVDFVDVSPK QVVAVATACI PFLENDDSNR ALMGANMQRQ
660 670 680 690 700
AVPLIDPKAP YVGTGMEYQA AHDSGAAVIA QHNGKVVFSD AEKVEIRRQD
710 720 730 740 750
GSLDVYHITK FRRSNSGTAY NQRTLVKVGD IVEKGDFIAD GPSMENGEMA
760 770 780 790 800
LGQNPVVAYM TWEGYNFEDA VIMSERLVKE DVYTSVHLEE FESETRDTKL
810 820 830 840 850
GPEEITREIP NVGEEALKDL DEMGIIRIGA EVKEGDILVG KVTPKGEKDL
860 870 880 890 900
SAEERLLHAI FGDKSREVRD TSLRVPHGGD GIVRDVKIFT RANGDELQSG
910 920 930 940 950
VNMLVRVYIA QKRKIKVGDK MAGRHGNKGV VSRIVPVEDM PYLPDGTPVD
960 970 980 990 1000
IMLNPLGVPS RMNIGQVMEL HLGMAARNLG IHIATPVFDG ASSEDLWDTV
1010 1020 1030 1040 1050
REAGMDSDAK TVLYDGRTGE PFDNRVSVGV MYMIKLHHMV DDKLHARSVG
1060 1070 1080 1090 1100
PYSLVTQQPL GGKAQFGGQR FGEMEVWALE AYGASNVLQE ILTYKSDDVT
1110 1120 1130 1140 1150
GRLKAYEAIT KGKPIPKPGV PESFRVLVKE LQSLGLDMRV LDEDDNEVEL
1160 1170 1180
RDLDEGEDDD IMHVDDLEKA REKQAQETQE VSETTDEK
Length:1,188
Mass (Da):132,855
Last modified:March 6, 2007 - v1
Checksum:i1F2B555D1E1D7F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM29423.1.
RefSeqiWP_002986567.1. NC_009332.1.

Genome annotation databases

KEGGispf:SpyM50081.
PATRICi19763228. VBIStrPyo41547_0088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295007 Genomic DNA. Translation: CAM29423.1.
RefSeqiWP_002986567.1. NC_009332.1.

3D structure databases

ProteinModelPortaliA2RC51.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2RC51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGispf:SpyM50081.
PATRICi19763228. VBIStrPyo41547_0088.

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-126-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiRPOB_STRPG
AccessioniPrimary (citable) accession number: A2RC51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 6, 2007
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.