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A2RBZ5

- PUR5_STRPG

UniProt

A2RBZ5 - PUR5_STRPG

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, SpyM50024
Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160491:GJ8O-56-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SpyM50024
OrganismiStreptococcus pyogenes serotype M5 (strain Manfredo)
Taxonomic identifieri160491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002591: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000046476Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160491.SpyM50024.

Structurei

3D structure databases

ProteinModelPortaliA2RBZ5.
SMRiA2RBZ5. Positions 15-332.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiPDMYGAD.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A2RBZ5-1 [UniParc]FASTAAdd to Basket

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MSEKNAYAKS GVDVEAGYEV VERIKKHVAR TERAGVMGVL GGFGGMFDLS    50
KTGVKEPVLV SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE 100
PLYFLDYIAT GKNNPVKLEE VVSGVAEGCV QAGVALIGDE TAEMPGMYGE 150
DDYDLAGFAV GVAEKSQIID GSKVKEGDIL LGLASSGIHS NGYSLVRRVF 200
ADYTGKELLP ELEGKQLKDV LLEPTRIYVK AALPLIKEEL VNGIGHITGG 250
GFIENVPRMF ADDLAAEIDE DKVPVLPIFK ALEKYGDIKH EEMFEIFNMG 300
VGLMLAVSPE NVNRVKDLLD EPVYEIGRII KKADDSVVIK 340
Length:340
Mass (Da):36,588
Last modified:March 6, 2007 - v1
Checksum:iEC167B2B6BE0F0F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM29367.1.
RefSeqiWP_011888520.1. NC_009332.1.
YP_001127625.1. NC_009332.1.

Genome annotation databases

GeneIDi4964404.
KEGGispf:SpyM50024.
PATRICi19763072. VBIStrPyo41547_0026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM295007 Genomic DNA. Translation: CAM29367.1 .
RefSeqi WP_011888520.1. NC_009332.1.
YP_001127625.1. NC_009332.1.

3D structure databases

ProteinModelPortali A2RBZ5.
SMRi A2RBZ5. Positions 15-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160491.SpyM50024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4964404.
KEGGi spf:SpyM50024.
PATRICi 19763072. VBIStrPyo41547_0026.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi PDMYGAD.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SPYO160491:GJ8O-56-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Manfredo.

Entry informationi

Entry nameiPUR5_STRPG
AccessioniPrimary (citable) accession number: A2RBZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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