A2RBA1 (RT106_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone chaperone rtt106

Gene names

Name:	rtt106
ORF Names:	An18g06020

Organism

Aspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]

Taxonomic identifier

425011 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus niger

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter By similarity.
Subunit structure	Interacts with histones H3 and H4 By similarity.
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the RTT106 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	DNA-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Histone chaperone rtt106		PRO_0000320484

Sequences

	Sequence		Length	Mass (Da)
	A2RBA1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 053AEFE3FBD85B59	FASTA	458	50,310
	10 20 30 40 50 60 MAFATINSSV PSSIPAIEDA FAAEPALKKR VYDAIAHTPQ HGLLFEDIAK YTSSLLARTA 70 80 90 100 110 120 TAPVRPVEVV SDGPAMKKRK LQNGNATSAQ SSGDLKSDTS LQFYMQDVSF AVPQRKKLTL 130 140 150 160 170 180 EVTAGFLRAR NQTSKEVEFG VPLDNIQHVL CLPVPEKNQR QFNFCIIPQY ADGVNSPPEG 190 200 210 220 230 240 VAAPDAIVWT VNDGPPKAAF SGNGQQLGTD NEETADKLVQ RILNDSLPRT KVVRPDEREF 250 260 270 280 290 300 VSAMPEAHRK GEKAFHVKAF RGSKEGYLFL LSTGILFGFK KPLVFFAFEN VDSISYTSVL 310 320 330 340 350 360 QRTFNLNVVA RPTSSEETQE FEFSMIDQAD FSGIDGYIKK HGLQDASLAE ARRAKRYNVN 370 380 390 400 410 420 GAKGEDEAAA NEEGAVEEES ELQKAQRELE DQEDEDEEDY DPGSDSDSDG SGSSSEEDDD 430 440 450 DDEEDDEGDM EEDDEEGDRN LVAEELGSEA EDVPAEEL

References

[1]

"Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88." Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M. , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H. Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBS 513.88 / FGSC A1513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM270411 Genomic DNA. Translation: CAK43325.1.
RefSeq	XP_001399053.1. XM_001399016.1.
3D structure databases
ProteinModelPortal	A2RBA1.
ModBase	Search...
Protein-protein interaction databases
STRING	5061.CADANGAP00013971.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANGAT00014240; CADANGAP00013971; CADANGAG00014240.
GeneID	4990168.
KEGG	ang:ANI_1_806164.
Phylogenomic databases
eggNOG	NOG78439.
HOGENOM	HOG000048523.
OrthoDB	EOG4HTD28.
Family and domain databases
InterPro	IPR013719. DUF1747. [Graphical view]
Pfam	PF08512. Rtt106. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RT106_ASPNC

Accession

Primary (citable) accession number: A2RBA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program