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Protein

Probable arabinogalactan endo-beta-1,4-galactanase A

Gene

galA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.By similarity

Catalytic activityi

The enzyme specifically hydrolyzes (1->4)-beta-D-galactosidic linkages in type I arabinogalactans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Proton donorBy similarity1
Active sitei262NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH53. Glycoside Hydrolase Family 53.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arabinogalactan endo-beta-1,4-galactanase A (EC:3.2.1.89)
Alternative name(s):
Endo-1,4-beta-galactanase A
Short name:
Galactanase A
Gene namesi
Name:galA
ORF Names:An18g05940
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 8L

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500022135417 – 350Probable arabinogalactan endo-beta-1,4-galactanase AAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA2RB93.
SMRiA2RB93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 53 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000217077.
OrthoDBiEOG092C2PF8.

Family and domain databases

InterProiView protein in InterPro
IPR011683. Glyco_hydro_53.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF07745. Glyco_hydro_53. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RB93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYSLLLSAL PLLSSAALTY RGADISSLLI EEDAGISYKN LNGETQALED
60 70 80 90 100
ILVNNGVNSI RQRVWVDPSD GSYDLDYNLK LAKRVQAAGM SIYLDLHLSD
110 120 130 140 150
TWADPSDQTT PTGWSTTDID TLTWQLYNYT LDVCNTFAEN DIDIEIVSIG
160 170 180 190 200
NEISSGLLWP LGKTSNYDNI AKLLHSGAWG VKDSNQATTP KIMIHLDNGW
210 220 230 240 250
DWEEQEYFYK TVLATGSLLS TDFDLMGVSY YPFYSSEATL SALQTSLTNM
260 270 280 290 300
QSNYDKSVVV VETNWPVSCP DPEYSFPSDL SSIPFSAAGQ EEFLEKLAEV
310 320 330 340 350
VEGVTDGLGI YYWEPAWVDN AALGSSCADN LMVDIDTDEV LESVTVFEDL
Length:350
Mass (Da):38,697
Last modified:March 6, 2007 - v1
Checksum:i7BB458494EC916FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270410 Genomic DNA. Translation: CAK43317.1.

Genome annotation databases

EnsemblFungiiCAK43317; CAK43317; An18g05940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270410 Genomic DNA. Translation: CAK43317.1.

3D structure databases

ProteinModelPortaliA2RB93.
SMRiA2RB93.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH53. Glycoside Hydrolase Family 53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAK43317; CAK43317; An18g05940.

Phylogenomic databases

HOGENOMiHOG000217077.
OrthoDBiEOG092C2PF8.

Family and domain databases

InterProiView protein in InterPro
IPR011683. Glyco_hydro_53.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF07745. Glyco_hydro_53. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGANA_ASPNC
AccessioniPrimary (citable) accession number: A2RB93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: May 10, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.