Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210Proton donorBy similarity1
Active sitei308NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation
LigandManganese, Metal-binding

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:An18g04100
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 8L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500022133223 – 416Probable glucan 1,3-beta-glucosidase AAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 415By similarity
Disulfide bondi316 ↔ 342By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2RAR6

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00013786

Structurei

3D structure databases

ProteinModelPortaliA2RAR6
SMRiA2RAR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
KOiK01210
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RAR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVESAKKAL LALSLLAASA QAVPRVRRQG ASSSFDYKSQ IVRGVNLGGW
60 70 80 90 100
LVTEPWITPS LYDSTGGGAV DEWTLCQILG KDEAQAKLSS HWSSFITQSD
110 120 130 140 150
FDRMAQAGLN HVRIPIGYWA VAPIDGEPYV SGQIDYLDQA VTWARAAGLK
160 170 180 190 200
VLVDLHGAPG SQNGFDNSGH RGPIQWQQGD TVNQTMTAFD ALARRYAQSD
210 220 230 240 250
TVTAIEAVNE PNIPGGVNED GLKNYYYGAL ADVQRLNPST TLFMSDGFQP
260 270 280 290 300
VESWNGFMQG SNVVMDTHHY QVFDTGLLSM SIDDHVKTAC SLATQHTMQS
310 320 330 340 350
DKPVVVGEWT GALTDCAKYL NGVGNAARYD GTYMSTTKYG DCTGKSTGSV
360 370 380 390 400
ADFSADEKAN TRRYIEAQLE AYEMKSGWLF WTWKTEGAPG WDMQDLLANQ
410
LFPTSPTDRQ YPHQCS
Length:416
Mass (Da):45,526
Last modified:March 6, 2007 - v1
Checksum:i9FC5AADB23A03E24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270406 Genomic DNA Translation: CAK43212.1
RefSeqiXP_001398868.1, XM_001398831.2

Genome annotation databases

EnsemblFungiiCAK43212; CAK43212; An18g04100
GeneIDi4989974
KEGGiang:ANI_1_534164

Similar proteinsi

Entry informationi

Entry nameiEXGA_ASPNC
AccessioniPrimary (citable) accession number: A2RAR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health