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Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei280By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular carbohydrate catabolic process Source: ASPGD
  • cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase A
Cellobiase A
Gentiobiase A
Gene namesi
Name:bglA
Synonyms:bgl1
ORF Names:An18g03570
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 8L

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500022132320 – 860Probable beta-glucosidase AAdd BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi442N-linked (GlcNAc...)Sequence analysis1
Glycosylationi523N-linked (GlcNAc...)Sequence analysis1
Glycosylationi542N-linked (GlcNAc...)Sequence analysis1
Glycosylationi564N-linked (GlcNAc...)Sequence analysis1
Glycosylationi658N-linked (GlcNAc...)Sequence analysis1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1
Glycosylationi712N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA2RAL4.

Structurei

3D structure databases

ProteinModelPortaliA2RAL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215.
KOiK05349.
OrthoDBiEOG092C0ZJY.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 4 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2RAL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFTSIEAVA LTAVSLASAD ELAYSPPYYP SPWANGQGDW AEAYQRAVDI
60 70 80 90 100
VSQMTLAEKV NLTTGTGWEL ELCVGQTGGV PRLGIPGMCA QDSPLGVRDS
110 120 130 140 150
DYNSAFPAGV NVAATWDKNL AYLRGQAMGQ EFSDKGADIQ LGPAAGPLGR
160 170 180 190 200
SPDGGRNWEG FSPDPALSGV LFAETIKGIQ DAGVVATAKH YIAYEQEHFR
210 220 230 240 250
QAPEAQGYGF NITESGSANL DDKTMHELYL WPFADAIRAG AGAVMCSYNQ
260 270 280 290 300
INNSYGCQNS YTLNKLLKAE LGFQGFVMSD WAAHHAGVSG ALAGLDMSMP
310 320 330 340 350
GDVDYDSGTS YWGTNLTISV LNGTVPQWRV DDMAVRIMAA YYKVGRDRLW
360 370 380 390 400
TPPNFSSWTR DEYGFKYYYV SEGPYEKVNQ FVNVQRNHSE LIRRIGADST
410 420 430 440 450
VLLKNDGALP LTGKERLVAL IGEDAGSNPY GANGCSDRGC DNGTLAMGWG
460 470 480 490 500
SGTANFPYLV TPEQAISNEV LKNKNGVFTA TDNWAIDQIE ALAKTASVSL
510 520 530 540 550
VFVNADSGEG YINVDGNLGD RRNLTLWRNG DNVIKAAASN CNNTIVIIHS
560 570 580 590 600
VGPVLVNEWY DNPNVTAILW GGLPGQESGN SLADVLYGRV NPGAKSPFTW
610 620 630 640 650
GKTREAYQDY LYTEPNNGNG APQEDFVEGV FIDYRGFDKR NETPIYEFGY
660 670 680 690 700
GLSYTTFNYS NLQVEVLSAP AYEPASGETE AAPTFGEVGN ASDYLYPDGL
710 720 730 740 750
QRITKFIYPW LNSTDLEASS GDASYGQDAS DYLPEGATDG SAQPILPAGG
760 770 780 790 800
GAGGNPRLYD ELIRVSVTIK NTGKVAGDEV PQLYVSLGGP NEPKIVLRQF
810 820 830 840 850
ERITLQPSKE TQWSTTLTRR DLANWNVETQ DWEITSYPKM VFAGSSSRKL
860
PLRASLPTVH
Length:860
Mass (Da):93,229
Last modified:March 6, 2007 - v1
Checksum:i087215D2E1F89643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270402 Genomic DNA. Translation: CAK48740.1.
RefSeqiXP_001398816.1. XM_001398779.2.

Genome annotation databases

EnsemblFungiiCAK48740; CAK48740; An18g03570.
GeneIDi4989921.
KEGGiang:ANI_1_456164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270402 Genomic DNA. Translation: CAK48740.1.
RefSeqiXP_001398816.1. XM_001398779.2.

3D structure databases

ProteinModelPortaliA2RAL4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Proteomic databases

PRIDEiA2RAL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAK48740; CAK48740; An18g03570.
GeneIDi4989921.
KEGGiang:ANI_1_456164.

Phylogenomic databases

HOGENOMiHOG000031215.
KOiK05349.
OrthoDBiEOG092C0ZJY.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 4 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGLA_ASPNC
AccessioniPrimary (citable) accession number: A2RAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.