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A2R797 (AFCA_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable alpha-fucosidase A

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene names
Name:afcA
ORF Names:An16g02760
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose By similarity.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 95 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalpha-L-fucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 793773Probable alpha-fucosidase A
PRO_5000221152

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation5971N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation6601N-linked (GlcNAc...) Potential
Glycosylation7571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A2R797 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 4F510561054875E2

FASTA79386,565
        10         20         30         40         50         60 
MLISGSSAAL CALALPFAAA KSLWSDSPGN YSSFITTAFP LGNGRLGAMP IGSYDKEIVN 

        70         80         90        100        110        120 
LNVDSLWRGG PFESPTYSGG NPNVSKAGAL PGIREWIFQN GTGNVSALLG EYPYYGSYQV 

       130        140        150        160        170        180 
LANLTIDMGE LSDIDGYRRN LDLDSAVYSD HFSTGETYIE REAFCSYPDN VCVYRLSSNS 

       190        200        210        220        230        240 
SLPEITFGLE NQLTSPAPNV SCHGNSISLY GQTYPVIGMI YNARVTVVVP GSSNTTDLCS 

       250        260        270        280        290        300 
SSTVKVPEGE KEVFLVFAAD TNYEASNGNS KASFSFKGEN PYMKVLQTAT NAAKKSYSAL 

       310        320        330        340        350        360 
KSSHVKDYQG VFNKFTLTLP DPNGSADRPT TELLSSYSQP GDPYVENLLF DYGRYLFISS 

       370        380        390        400        410        420 
SRPGSLPPNL QGLWTESYSP AWSGDYHANI NLQMNHWAVD QTGLGELTEP LWTYMAETWM 

       430        440        450        460        470        480 
PRGAETAELL YGTSEGWVTH DEMNTFGHTA MKDVAQWADY PATNAWMSHH VWDHFDYSQD 

       490        500        510        520        530        540 
SAWYRETGYP ILKGAAQFWL SQLVKDEYFK DGTLVVNPCN SPEHGPTLTP QTFGCTHYQQ 

       550        560        570        580        590        600 
LIWELFDHVL QGWTASGDDD TSFKNAITSK FSTLDPGIHI GSWGQIQEWK LDIDVKNDTH 

       610        620        630        640        650        660 
RHLSNLYGWY PGYIISSVHG SNKTITDAVE TTLYSRGTGV EDSNTGWAKV WRSACWALLN 

       670        680        690        700        710        720 
VTDEAYSELS LAIQDNFAEN GFDMYSGSPP FQIDANFGLV GAMVQMLIRD SDRSSADASA 

       730        740        750        760        770        780 
GKTQDVLLGP AIPAAWGGGS VGGLRLRGGG VVSFSWNDSG VVDSCKADLS ARGSDVSQVK 

       790 
FYVAGGRAID CSS 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270362 Genomic DNA. Translation: CAK48586.1.

3D structure databases

ProteinModelPortalA2R797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00012507.

Protein family/group databases

CAZyGH95. Glycoside Hydrolase Family 95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00012747; CADANGAP00012507; CADANGAG00012747.

Phylogenomic databases

eggNOGNOG04067.
HOGENOMHOG000235039.
OrthoDBEOG77HDP8.

Family and domain databases

Gene3D2.70.98.50. 1 hit.
InterProIPR008928. 6-hairpin_glycosidase-like.
IPR016518. Alpha-L-fucosidase.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
PIRSFPIRSF007663. UCP007663. 1 hit.
SUPFAMSSF48208. SSF48208. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAFCA_ASPNC
AccessionPrimary (citable) accession number: A2R797
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries