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Protein

Probable alpha-fucosidase A

Gene

afcA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose (By similarity).By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Protein family/group databases

CAZyiGH95 Glycoside Hydrolase Family 95

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-fucosidase A (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene namesi
Name:afcA
ORF Names:An16g02760
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500022115221 – 793Probable alpha-fucosidase AAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi757N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2R797
PRIDEiA2R797

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012507

Structurei

3D structure databases

ProteinModelPortaliA2R797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 95 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000235039
OrthoDBiEOG092C0OYW

Family and domain databases

Gene3Di1.50.10.10, 2 hits
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR016518 Alpha-L-fucosidase
IPR027414 GH95_N_dom
PfamiView protein in Pfam
PF14498 Glyco_hyd_65N_2, 1 hit
PIRSFiPIRSF007663 UCP007663, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2R797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLISGSSAAL CALALPFAAA KSLWSDSPGN YSSFITTAFP LGNGRLGAMP
60 70 80 90 100
IGSYDKEIVN LNVDSLWRGG PFESPTYSGG NPNVSKAGAL PGIREWIFQN
110 120 130 140 150
GTGNVSALLG EYPYYGSYQV LANLTIDMGE LSDIDGYRRN LDLDSAVYSD
160 170 180 190 200
HFSTGETYIE REAFCSYPDN VCVYRLSSNS SLPEITFGLE NQLTSPAPNV
210 220 230 240 250
SCHGNSISLY GQTYPVIGMI YNARVTVVVP GSSNTTDLCS SSTVKVPEGE
260 270 280 290 300
KEVFLVFAAD TNYEASNGNS KASFSFKGEN PYMKVLQTAT NAAKKSYSAL
310 320 330 340 350
KSSHVKDYQG VFNKFTLTLP DPNGSADRPT TELLSSYSQP GDPYVENLLF
360 370 380 390 400
DYGRYLFISS SRPGSLPPNL QGLWTESYSP AWSGDYHANI NLQMNHWAVD
410 420 430 440 450
QTGLGELTEP LWTYMAETWM PRGAETAELL YGTSEGWVTH DEMNTFGHTA
460 470 480 490 500
MKDVAQWADY PATNAWMSHH VWDHFDYSQD SAWYRETGYP ILKGAAQFWL
510 520 530 540 550
SQLVKDEYFK DGTLVVNPCN SPEHGPTLTP QTFGCTHYQQ LIWELFDHVL
560 570 580 590 600
QGWTASGDDD TSFKNAITSK FSTLDPGIHI GSWGQIQEWK LDIDVKNDTH
610 620 630 640 650
RHLSNLYGWY PGYIISSVHG SNKTITDAVE TTLYSRGTGV EDSNTGWAKV
660 670 680 690 700
WRSACWALLN VTDEAYSELS LAIQDNFAEN GFDMYSGSPP FQIDANFGLV
710 720 730 740 750
GAMVQMLIRD SDRSSADASA GKTQDVLLGP AIPAAWGGGS VGGLRLRGGG
760 770 780 790
VVSFSWNDSG VVDSCKADLS ARGSDVSQVK FYVAGGRAID CSS
Length:793
Mass (Da):86,565
Last modified:March 6, 2007 - v1
Checksum:i4F510561054875E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270362 Genomic DNA Translation: CAK48586.1

Genome annotation databases

EnsemblFungiiCAK48586; CAK48586; An16g02760

Entry informationi

Entry nameiAFCA_ASPNC
AccessioniPrimary (citable) accession number: A2R797
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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