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A2R797

- AFCA_ASPNC

UniProt

A2R797 - AFCA_ASPNC

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Protein

Probable alpha-fucosidase A

Gene

afcA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose (By similarity).By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Protein family/group databases

CAZyiGH95. Glycoside Hydrolase Family 95.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-fucosidase A (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene namesi
Name:afcA
ORF Names:An16g02760
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 5R

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 793773Probable alpha-fucosidase APRO_5000221152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi660 – 6601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012507.

Structurei

3D structure databases

ProteinModelPortaliA2R797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 95 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG04067.
HOGENOMiHOG000235039.
OrthoDBiEOG77HDP8.

Family and domain databases

Gene3Di2.70.98.50. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR016518. Alpha-L-fucosidase.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamiPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
PIRSFiPIRSF007663. UCP007663. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2R797-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLISGSSAAL CALALPFAAA KSLWSDSPGN YSSFITTAFP LGNGRLGAMP
60 70 80 90 100
IGSYDKEIVN LNVDSLWRGG PFESPTYSGG NPNVSKAGAL PGIREWIFQN
110 120 130 140 150
GTGNVSALLG EYPYYGSYQV LANLTIDMGE LSDIDGYRRN LDLDSAVYSD
160 170 180 190 200
HFSTGETYIE REAFCSYPDN VCVYRLSSNS SLPEITFGLE NQLTSPAPNV
210 220 230 240 250
SCHGNSISLY GQTYPVIGMI YNARVTVVVP GSSNTTDLCS SSTVKVPEGE
260 270 280 290 300
KEVFLVFAAD TNYEASNGNS KASFSFKGEN PYMKVLQTAT NAAKKSYSAL
310 320 330 340 350
KSSHVKDYQG VFNKFTLTLP DPNGSADRPT TELLSSYSQP GDPYVENLLF
360 370 380 390 400
DYGRYLFISS SRPGSLPPNL QGLWTESYSP AWSGDYHANI NLQMNHWAVD
410 420 430 440 450
QTGLGELTEP LWTYMAETWM PRGAETAELL YGTSEGWVTH DEMNTFGHTA
460 470 480 490 500
MKDVAQWADY PATNAWMSHH VWDHFDYSQD SAWYRETGYP ILKGAAQFWL
510 520 530 540 550
SQLVKDEYFK DGTLVVNPCN SPEHGPTLTP QTFGCTHYQQ LIWELFDHVL
560 570 580 590 600
QGWTASGDDD TSFKNAITSK FSTLDPGIHI GSWGQIQEWK LDIDVKNDTH
610 620 630 640 650
RHLSNLYGWY PGYIISSVHG SNKTITDAVE TTLYSRGTGV EDSNTGWAKV
660 670 680 690 700
WRSACWALLN VTDEAYSELS LAIQDNFAEN GFDMYSGSPP FQIDANFGLV
710 720 730 740 750
GAMVQMLIRD SDRSSADASA GKTQDVLLGP AIPAAWGGGS VGGLRLRGGG
760 770 780 790
VVSFSWNDSG VVDSCKADLS ARGSDVSQVK FYVAGGRAID CSS
Length:793
Mass (Da):86,565
Last modified:March 6, 2007 - v1
Checksum:i4F510561054875E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270362 Genomic DNA. Translation: CAK48586.1.

Genome annotation databases

EnsemblFungiiCADANGAT00012747; CADANGAP00012507; CADANGAG00012747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270362 Genomic DNA. Translation: CAK48586.1 .

3D structure databases

ProteinModelPortali A2R797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00012507.

Protein family/group databases

CAZyi GH95. Glycoside Hydrolase Family 95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00012747 ; CADANGAP00012507 ; CADANGAG00012747 .

Phylogenomic databases

eggNOGi NOG04067.
HOGENOMi HOG000235039.
OrthoDBi EOG77HDP8.

Family and domain databases

Gene3Di 2.70.98.50. 1 hit.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR016518. Alpha-L-fucosidase.
IPR027414. GH_fam_N_dom.
[Graphical view ]
Pfami PF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF007663. UCP007663. 1 hit.
SUPFAMi SSF48208. SSF48208. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiAFCA_ASPNC
AccessioniPrimary (citable) accession number: A2R797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3