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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

An15g07390

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
ORF Names:An15g07390Imported
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706 Componenti: Chromosome 3R

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012183.

Structurei

3D structure databases

ProteinModelPortaliA2R6C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni331 – 3322Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246855.
KOiK00006.
OrthoDBiEOG7V76H7.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2R6C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEHTRKHKV AVVGSGNWGS TISKIVAENA REHSDLFEPE VRMWVFEEEI
60 70 80 90 100
EIPESSKHHS KLGGQKHKLT EVINGVHENV KYLPDIALPE NVVADPDLKS
110 120 130 140 150
AVKDATLLVF NLPHQFIGKT LDGVVGHHLP YARGISCIKG VDVSDGTVTL
160 170 180 190 200
HSELIMERLG IYCGALSGAN IAPEVAAEKF CETTIGYDTP PMDVEERDGS
210 220 230 240 250
PKENLIKIDE QRQHKTKPTH VKLHPVPKDL PPVDAELWET LFARPYFHVN
260 270 280 290 300
HVRDVAGVAL GGALKNIVAL ASGFVAGKGW GENAKAAIMR VGILEMIKFG
310 320 330 340 350
RTWFPKSVDE RTFTEESAGL ADVISSCSGG RNFRSACHAV EQGVSVNEIE
360 370 380 390 400
QKELNGQKLQ GTSTAYAVYD FLSKHDQLKE FPLFVAVHDI LEGKSTVDDL
410
PALLDGKKKK NKSA
Length:414
Mass (Da):45,449
Last modified:March 6, 2007 - v1
Checksum:i5E64C900A03584EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270351 Genomic DNA. Translation: CAK48573.1.
RefSeqiXP_001397265.1. XM_001397228.1.

Genome annotation databases

EnsemblFungiiCADANGAT00012418; CADANGAP00012183; CADANGAG00012418.
GeneIDi4988340.
KEGGiang:ANI_1_1768134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270351 Genomic DNA. Translation: CAK48573.1.
RefSeqiXP_001397265.1. XM_001397228.1.

3D structure databases

ProteinModelPortaliA2R6C3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00012183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANGAT00012418; CADANGAP00012183; CADANGAG00012418.
GeneIDi4988340.
KEGGiang:ANI_1_1768134.

Phylogenomic databases

HOGENOMiHOG000246855.
KOiK00006.
OrthoDBiEOG7V76H7.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G., Debets A.J., Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J., d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P., van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U., Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P., van Ooyen A.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513Imported.

Entry informationi

Entry nameiA2R6C3_ASPNC
AccessioniPrimary (citable) accession number: A2R6C3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.