ID   A2R650_ASPNC            Unreviewed;      1362 AA.
AC   A2R650;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Contig An15c0220, genomic contig {ECO:0000313|EMBL:CAK42617.1};
GN   ORFNames=An15g06650 {ECO:0000313|EMBL:CAK42617.1};
OS   Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK42617.1, ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK42617.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC   {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
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DR   EMBL; AM270349; CAK42617.1; -; Genomic_DNA.
DR   EnsemblFungi; CAK42617; CAK42617; An15g06650.
DR   VEuPathDB; FungiDB:An15g06650; -.
DR   HOGENOM; CLU_002632_0_1_1; -.
DR   Proteomes; UP000006706; Chromosome 3R.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1309..1328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          85..148
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          797..930
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          966..1202
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          53..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..165
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1362 AA;  152300 MW;  E35233AE9FC318FD CRC64;
     MFDSRVAEPL AVDTGSALAT KTNTYTATFE YPDEQVTTPT TGSRSRANSL SFQQSSLTAN
     QSPTRRISSM KLTTDGRYTP SPEPPPALFV RAMYDYDADD HTSLSFRRGD IIQVLNQLET
     GWWDGVIDNN LGELEEQGPQ THENEEVSAE SGIGEEYEEE QDGDDVDSAG NPRDSQPILP
     IEGVGAPKEQ EEAAFWIPQA TPDGRLFYFN TLTGYSTMEL PFENPAVNET GPYDRNNFLV
     PDQTRPPPEL MARGFERDED DYDGSASEAE GESLMLTSRD SMSRRRQSYL DGVSPATSMD
     SLHPPSATKS INDGKSSHQS LLTSHKFYDS ATSSNNSVSD NIHRPSVSSE VPSHFVDDGF
     SVQLTWPLLV DNMRHAVEVY RQTLLNGDRS EYVRKAEDIS DHLRMLLAAG SDTTDNHSGN
     PSVISTNKAL YPHFRDMMSK FSKLVLSSHI AAADWPGPDS INKCLQEADG VMQGVYGYVE
     VARQQRGETI HRIVPGFVVG SFSGGCWQNN GVSLSDSGPT SFLDHDANDS RAEPSVTLDA
     ALIDHIDILR RSFVGSIRRL EERLTLNQKK IVTIKEHEEI ANAVSLAAIK VVEQFRPWMS
     AVESINLAPL GTSFQNPQLV DFSLQKQRTY DAIADFVLSC QAVSAPLGDE WAELRGNSLD
     DRLNAVRGVH RQLENYVSQI GFSLSLLLEQ VPEPSAFRAE SRLGGENAGL KAIHSRSESQ
     AGVATESIGI PSSYSVENAS EKVRRNMDKA QRFFGQAPPA AIPREPAMRE PVREPEETPW
     FLKTDHEGEV FYDTKNDSLN LKCGTLAGLV EQLTRHDKLD ASFNNTFLLT YRSFTSAEEL
     FEMVTERFNI QPPPGLNNDE MQMWIDRKQK PIRFRVVNIL KSWFENFWME PNDEPHMALL
     QHVHAFTKDS IATTKTPGSP QLLAVIEQRL RGQDNTVKRL VPTQATAAPT PIIPKNMKKL
     KFLDIDATEF ARQLTIIESR LYSKIRPTEC LNKTWQKKVG PDEPEPASNV KALILHSNQL
     TNWVAEMILN QSDVKKRVVV IKHFVNVADK CRALNNYSTL TSIISALGTA PIHRLGRTWA
     QVSGRTSTVL EQMRRLMAST KNFGEYRETL HLANPPCIPF FGVYLTDLTF IEDGIPSLTP
     SELINFNKRA KTAEVIRDIQ QYQNVPYLLQ PVPELQDYIL SNLQNAGDVH DMYDRSLEVE
     PREREDEKIA SARLASILAS PPGLLITTPV DLLFTRPDPE RPPITMLERR PMARSQFTPA
     TPCNFISQGA GPMSRQIPRS EPPFRRVSPL SLSAATWPIK HFTWTSCDIF TLILGLAWTI
     VISLIEYCGS RCTRSSSNVT LSPKDAPVTF SSHDHQSMDY WF
//