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Protein
Submitted name:

Similarity: N-terminal half differs from all homologs

Gene

An15g06650

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Similarity: N-terminal half differs from all homologsImported
Gene namesi
ORF Names:An15g06650Imported
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 3R

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012110.

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation
Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

HOGENOMiHOG000167739.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2R650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDSRVAEPL AVDTGSALAT KTNTYTATFE YPDEQVTTPT TGSRSRANSL
60 70 80 90 100
SFQQSSLTAN QSPTRRISSM KLTTDGRYTP SPEPPPALFV RAMYDYDADD
110 120 130 140 150
HTSLSFRRGD IIQVLNQLET GWWDGVIDNN LGELEEQGPQ THENEEVSAE
160 170 180 190 200
SGIGEEYEEE QDGDDVDSAG NPRDSQPILP IEGVGAPKEQ EEAAFWIPQA
210 220 230 240 250
TPDGRLFYFN TLTGYSTMEL PFENPAVNET GPYDRNNFLV PDQTRPPPEL
260 270 280 290 300
MARGFERDED DYDGSASEAE GESLMLTSRD SMSRRRQSYL DGVSPATSMD
310 320 330 340 350
SLHPPSATKS INDGKSSHQS LLTSHKFYDS ATSSNNSVSD NIHRPSVSSE
360 370 380 390 400
VPSHFVDDGF SVQLTWPLLV DNMRHAVEVY RQTLLNGDRS EYVRKAEDIS
410 420 430 440 450
DHLRMLLAAG SDTTDNHSGN PSVISTNKAL YPHFRDMMSK FSKLVLSSHI
460 470 480 490 500
AAADWPGPDS INKCLQEADG VMQGVYGYVE VARQQRGETI HRIVPGFVVG
510 520 530 540 550
SFSGGCWQNN GVSLSDSGPT SFLDHDANDS RAEPSVTLDA ALIDHIDILR
560 570 580 590 600
RSFVGSIRRL EERLTLNQKK IVTIKEHEEI ANAVSLAAIK VVEQFRPWMS
610 620 630 640 650
AVESINLAPL GTSFQNPQLV DFSLQKQRTY DAIADFVLSC QAVSAPLGDE
660 670 680 690 700
WAELRGNSLD DRLNAVRGVH RQLENYVSQI GFSLSLLLEQ VPEPSAFRAE
710 720 730 740 750
SRLGGENAGL KAIHSRSESQ AGVATESIGI PSSYSVENAS EKVRRNMDKA
760 770 780 790 800
QRFFGQAPPA AIPREPAMRE PVREPEETPW FLKTDHEGEV FYDTKNDSLN
810 820 830 840 850
LKCGTLAGLV EQLTRHDKLD ASFNNTFLLT YRSFTSAEEL FEMVTERFNI
860 870 880 890 900
QPPPGLNNDE MQMWIDRKQK PIRFRVVNIL KSWFENFWME PNDEPHMALL
910 920 930 940 950
QHVHAFTKDS IATTKTPGSP QLLAVIEQRL RGQDNTVKRL VPTQATAAPT
960 970 980 990 1000
PIIPKNMKKL KFLDIDATEF ARQLTIIESR LYSKIRPTEC LNKTWQKKVG
1010 1020 1030 1040 1050
PDEPEPASNV KALILHSNQL TNWVAEMILN QSDVKKRVVV IKHFVNVADK
1060 1070 1080 1090 1100
CRALNNYSTL TSIISALGTA PIHRLGRTWA QVSGRTSTVL EQMRRLMAST
1110 1120 1130 1140 1150
KNFGEYRETL HLANPPCIPF FGVYLTDLTF IEDGIPSLTP SELINFNKRA
1160 1170 1180 1190 1200
KTAEVIRDIQ QYQNVPYLLQ PVPELQDYIL SNLQNAGDVH DMYDRSLEVE
1210 1220 1230 1240 1250
PREREDEKIA SARLASILAS PPGLLITTPV DLLFTRPDPE RPPITMLERR
1260 1270 1280 1290 1300
PMARSQFTPA TPCNFISQGA GPMSRQIPRS EPPFRRVSPL SLSAATWPIK
1310 1320 1330 1340 1350
HFTWTSCDIF TLILGLAWTI VISLIEYCGS RCTRSSSNVT LSPKDAPVTF
1360
SSHDHQSMDY WF
Length:1,362
Mass (Da):152,300
Last modified:March 6, 2007 - v1
Checksum:iE35233AE9FC318FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270349 Genomic DNA. Translation: CAK42617.1.

Genome annotation databases

EnsemblFungiiCADANGAT00012344; CADANGAP00012110; CADANGAG00012344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270349 Genomic DNA. Translation: CAK42617.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00012110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANGAT00012344; CADANGAP00012110; CADANGAG00012344.

Phylogenomic databases

HOGENOMiHOG000167739.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513Imported.

Entry informationi

Entry nameiA2R650_ASPNC
AccessioniPrimary (citable) accession number: A2R650
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: March 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.