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Protein

Xylanolytic transcriptional activator xlnR

Gene

xlnR

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGCTAAA-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 15127Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. transcription regulatory region DNA binding Source: ASPGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription from RNA polymerase II promoter Source: ASPGD
  3. xylan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Xylanolytic transcriptional activator xlnR
Alternative name(s):
Xylanase regulator
Gene namesi
Name:xlnR
ORF Names:An15g05810
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 3R

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Xylanolytic transcriptional activator xlnRPRO_0000393153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012027.

Family & Domainsi

Sequence similaritiesi

Belongs to the xlnR/xlr1 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000167193.
OrthoDBiEOG7380DB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2R5W7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPSIPQFT SPFSPFSSGS HSTGMAPSQT VGLDTLAEGS QYVLEQLQLS
60 70 80 90 100
RDAAGSGAGD GAPSTSLRNS MSHTKDQPPF DNEKNQSTGS GFRDALQRDP
110 120 130 140 150
LVEARSAIRK TSSSAPVRRR ISRACDQCNQ LRTKCDGQHP CAHCIEFGLT
160 170 180 190 200
CEYARERKKR GKASKKDLAA AAAAATQGSN GHSGQANASL MGERTSEDSR
210 220 230 240 250
PGQDVNGTYD SAFESHHLSS QPSHMQHAST AGISGLHESQ TAPSHSQPSL
260 270 280 290 300
GTTIDAMHLN HFNTMNDSGR PAMSISDLRS LPPSVLPPQG LSSGYNASAF
310 320 330 340 350
ALVNPQEPGS PANQFRLGSS AENPTAPFLG LSPPGQSPGW LPLPSPSPAN
360 370 380 390 400
FPSFSLHPFS STLRYPVLQP VLPHIASIIP QSLACDLLDV YFTSSSSSHL
410 420 430 440 450
SPLSPYVVGY IFRKQSFLHP TKPRICSPGL LASMLWVAAQ TSEAAFLTSP
460 470 480 490 500
PSARGRVCQK LLELTIGLLR PLVHGPATGE ASPNYAANMV INGVALGGFG
510 520 530 540 550
VSMDQLGAQS SATGAVDDVA TYVHLATVVS ASEYKAASMR WWTAAWSLAR
560 570 580 590 600
ELKLGRELPP NVSHARQDGE RDGDGEADKR HPPTLITSLG HGSGSSGINV
610 620 630 640 650
TEEEREERRR LWWLLYATDR HLALCYNRPL TLLDKECGGL LQPMNDDLWQ
660 670 680 690 700
VGDFAAAAYR QVGPPVECTG HSMYGYFLPL MTILGGIVDL HHAENHPRFG
710 720 730 740 750
LAFRNSPEWE RQVLDVTRQL DTYGRSLKEF EARYTSNLTL GATDNEPVVE
760 770 780 790 800
GAHLDHTSPS GRSSSTVGSR VSESIVHTRM VVAYGTHIMH VLHILLAGKW
810 820 830 840 850
DPVNLLEDHD LWISSESFVS AMSHAVGAAE AAAEILEYDP DLSFMPFFFG
860 870 880 890 900
IYLLQGSFLL LLAADKLQGD ASPSVVRACE TIVRAHEACV VTLNTEYQRT
910 920 930 940
FRKVMRSALA QVRGRIPEDF GEQQQRRREV LALYRWSGDG SGLAL
Length:945
Mass (Da):102,090
Last modified:March 23, 2010 - v2
Checksum:iB64027F642A49668
GO

Sequence cautioni

The sequence CAK42534.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270347 Genomic DNA. Translation: CAK42534.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270347 Genomic DNA. Translation: CAK42534.1. Sequence problems.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00012027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000167193.
OrthoDBiEOG7380DB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiXLNR_ASPNC
AccessioniPrimary (citable) accession number: A2R5W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: January 7, 2015
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.