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A2R5W7

- XLNR_ASPNC

UniProt

A2R5W7 - XLNR_ASPNC

Protein

Xylanolytic transcriptional activator xlnR

Gene

xlnR

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGCTAAA-3' By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi125 – 15127Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. transcription regulatory region DNA binding Source: ASPGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of transcription from RNA polymerase II promoter Source: ASPGD
    3. xylan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylanolytic transcriptional activator xlnR
    Alternative name(s):
    Xylanase regulator
    Gene namesi
    Name:xlnR
    ORF Names:An15g05810
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 3R

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 945945Xylanolytic transcriptional activator xlnRPRO_0000393153Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00012027.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xlnR/xlr1 family.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000167193.
    OrthoDBiEOG7380DB.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR007219. Transcription_factor_dom_fun.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF04082. Fungal_trans. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00906. Fungal_trans. 1 hit.
    SM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2R5W7-1 [UniParc]FASTAAdd to Basket

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    MSTPSIPQFT SPFSPFSSGS HSTGMAPSQT VGLDTLAEGS QYVLEQLQLS    50
    RDAAGSGAGD GAPSTSLRNS MSHTKDQPPF DNEKNQSTGS GFRDALQRDP 100
    LVEARSAIRK TSSSAPVRRR ISRACDQCNQ LRTKCDGQHP CAHCIEFGLT 150
    CEYARERKKR GKASKKDLAA AAAAATQGSN GHSGQANASL MGERTSEDSR 200
    PGQDVNGTYD SAFESHHLSS QPSHMQHAST AGISGLHESQ TAPSHSQPSL 250
    GTTIDAMHLN HFNTMNDSGR PAMSISDLRS LPPSVLPPQG LSSGYNASAF 300
    ALVNPQEPGS PANQFRLGSS AENPTAPFLG LSPPGQSPGW LPLPSPSPAN 350
    FPSFSLHPFS STLRYPVLQP VLPHIASIIP QSLACDLLDV YFTSSSSSHL 400
    SPLSPYVVGY IFRKQSFLHP TKPRICSPGL LASMLWVAAQ TSEAAFLTSP 450
    PSARGRVCQK LLELTIGLLR PLVHGPATGE ASPNYAANMV INGVALGGFG 500
    VSMDQLGAQS SATGAVDDVA TYVHLATVVS ASEYKAASMR WWTAAWSLAR 550
    ELKLGRELPP NVSHARQDGE RDGDGEADKR HPPTLITSLG HGSGSSGINV 600
    TEEEREERRR LWWLLYATDR HLALCYNRPL TLLDKECGGL LQPMNDDLWQ 650
    VGDFAAAAYR QVGPPVECTG HSMYGYFLPL MTILGGIVDL HHAENHPRFG 700
    LAFRNSPEWE RQVLDVTRQL DTYGRSLKEF EARYTSNLTL GATDNEPVVE 750
    GAHLDHTSPS GRSSSTVGSR VSESIVHTRM VVAYGTHIMH VLHILLAGKW 800
    DPVNLLEDHD LWISSESFVS AMSHAVGAAE AAAEILEYDP DLSFMPFFFG 850
    IYLLQGSFLL LLAADKLQGD ASPSVVRACE TIVRAHEACV VTLNTEYQRT 900
    FRKVMRSALA QVRGRIPEDF GEQQQRRREV LALYRWSGDG SGLAL 945
    Length:945
    Mass (Da):102,090
    Last modified:March 23, 2010 - v2
    Checksum:iB64027F642A49668
    GO

    Sequence cautioni

    The sequence CAK42534.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270347 Genomic DNA. Translation: CAK42534.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270347 Genomic DNA. Translation: CAK42534.1 . Sequence problems.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00012027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000167193.
    OrthoDBi EOG7380DB.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR007219. Transcription_factor_dom_fun.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF04082. Fungal_trans. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00906. Fungal_trans. 1 hit.
    SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiXLNR_ASPNC
    AccessioniPrimary (citable) accession number: A2R5W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3