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A2R5W7

- XLNR_ASPNC

UniProt

A2R5W7 - XLNR_ASPNC

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Protein
Xylanolytic transcriptional activator xlnR
Gene
xlnR, An15g05810
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGCTAAA-3' By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 15127Zn(2)-C6 fungal-type
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. transcription regulatory region DNA binding Source: ASPGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription from RNA polymerase II promoter Source: ASPGD
  3. xylan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Xylanolytic transcriptional activator xlnR
Alternative name(s):
Xylanase regulator
Gene namesi
Name:xlnR
ORF Names:An15g05810
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 3R

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Xylanolytic transcriptional activator xlnR
PRO_0000393153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00012027.

Family & Domainsi

Sequence similaritiesi

Belongs to the xlnR/xlr1 family.

Phylogenomic databases

HOGENOMiHOG000167193.
OrthoDBiEOG7380DB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2R5W7-1 [UniParc]FASTAAdd to Basket

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MSTPSIPQFT SPFSPFSSGS HSTGMAPSQT VGLDTLAEGS QYVLEQLQLS    50
RDAAGSGAGD GAPSTSLRNS MSHTKDQPPF DNEKNQSTGS GFRDALQRDP 100
LVEARSAIRK TSSSAPVRRR ISRACDQCNQ LRTKCDGQHP CAHCIEFGLT 150
CEYARERKKR GKASKKDLAA AAAAATQGSN GHSGQANASL MGERTSEDSR 200
PGQDVNGTYD SAFESHHLSS QPSHMQHAST AGISGLHESQ TAPSHSQPSL 250
GTTIDAMHLN HFNTMNDSGR PAMSISDLRS LPPSVLPPQG LSSGYNASAF 300
ALVNPQEPGS PANQFRLGSS AENPTAPFLG LSPPGQSPGW LPLPSPSPAN 350
FPSFSLHPFS STLRYPVLQP VLPHIASIIP QSLACDLLDV YFTSSSSSHL 400
SPLSPYVVGY IFRKQSFLHP TKPRICSPGL LASMLWVAAQ TSEAAFLTSP 450
PSARGRVCQK LLELTIGLLR PLVHGPATGE ASPNYAANMV INGVALGGFG 500
VSMDQLGAQS SATGAVDDVA TYVHLATVVS ASEYKAASMR WWTAAWSLAR 550
ELKLGRELPP NVSHARQDGE RDGDGEADKR HPPTLITSLG HGSGSSGINV 600
TEEEREERRR LWWLLYATDR HLALCYNRPL TLLDKECGGL LQPMNDDLWQ 650
VGDFAAAAYR QVGPPVECTG HSMYGYFLPL MTILGGIVDL HHAENHPRFG 700
LAFRNSPEWE RQVLDVTRQL DTYGRSLKEF EARYTSNLTL GATDNEPVVE 750
GAHLDHTSPS GRSSSTVGSR VSESIVHTRM VVAYGTHIMH VLHILLAGKW 800
DPVNLLEDHD LWISSESFVS AMSHAVGAAE AAAEILEYDP DLSFMPFFFG 850
IYLLQGSFLL LLAADKLQGD ASPSVVRACE TIVRAHEACV VTLNTEYQRT 900
FRKVMRSALA QVRGRIPEDF GEQQQRRREV LALYRWSGDG SGLAL 945
Length:945
Mass (Da):102,090
Last modified:March 23, 2010 - v2
Checksum:iB64027F642A49668
GO

Sequence cautioni

The sequence CAK42534.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270347 Genomic DNA. Translation: CAK42534.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270347 Genomic DNA. Translation: CAK42534.1 . Sequence problems.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00012027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000167193.
OrthoDBi EOG7380DB.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiXLNR_ASPNC
AccessioniPrimary (citable) accession number: A2R5W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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