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A2R5L8

- A2R5L8_ASPNC

UniProt

A2R5L8 - A2R5L8_ASPNC

Protein

Glutamate decarboxylase

Gene

An15g04770

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    ORF Names:An15g04770Imported
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 3R

    PTM / Processingi

    Proteomic databases

    PRIDEiA2R5L8.

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00011928.

    Structurei

    3D structure databases

    ProteinModelPortaliA2R5L8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000070228.
    KOiK01580.
    OrthoDBiEOG7P2Z22.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2R5L8-1 [UniParc]FASTAAdd to Basket

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    MVHLSTVRKE SHAHQRQREE RDAQAAAVSP YVYGTRYAVQ ELPEHSMSEN    50
    EMPAPVAYRM IKDELSLDGN PLLNLASFVT TYMEDEVQQL MSDAMSKNFI 100
    DYEQYPQTAH MQNRCVNMIA GLFHAPSIND PSNEQDAIGT STVGSSEAIM 150
    LAMLAMKKRW QNKRKEAGKD WSRPNIIMNS AVQVCWEKAA RYFEVEERYV 200
    YCTETRYVID PKEAVDLVDE NTVGICAILG TTYTGQYEDV KAINDLLIAK 250
    NIDCPIHVDA ASGGFVVPFV KPELEWDFRL EKVISINVSG HKYGLVYPGV 300
    GWVFWRAPEY LPKELIFNIN YLGAEQASFT LNFSKGAPHV IGQYYQLIRL 350
    GKHGFRSIMT NLTQTADHLA AELEKLGFII MSEGGGRGLP LVAFRLPEQE 400
    GRLYDEFALA HVLRRRGWVI PAYTMAPKCN QLRMMRIVLR EDFSLHRCNL 450
    LVEDIRLGLK TLEDMDETMV KRYSTYIQTH ATRGPQGHPV YGNEQHSLQG 500
    KSGKTHAVC 509
    Length:509
    Mass (Da):57,785
    Last modified:March 6, 2007 - v1
    Checksum:iE9AB024CBC665228
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270344 Genomic DNA. Translation: CAK42454.1.
    RefSeqiXP_001397011.1. XM_001396974.2.

    Genome annotation databases

    EnsemblFungiiCADANGAT00012156; CADANGAP00011928; CADANGAG00012156.
    GeneIDi4988078.
    KEGGiang:ANI_1_662134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270344 Genomic DNA. Translation: CAK42454.1 .
    RefSeqi XP_001397011.1. XM_001396974.2.

    3D structure databases

    ProteinModelPortali A2R5L8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00011928.

    Proteomic databases

    PRIDEi A2R5L8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00012156 ; CADANGAP00011928 ; CADANGAG00012156 .
    GeneIDi 4988078.
    KEGGi ang:ANI_1_662134.

    Phylogenomic databases

    HOGENOMi HOG000070228.
    KOi K01580.
    OrthoDBi EOG7P2Z22.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513Imported.

    Entry informationi

    Entry nameiA2R5L8_ASPNC
    AccessioniPrimary (citable) accession number: A2R5L8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3