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A2R350

- NTE1_ASPNC

UniProt

A2R350 - NTE1_ASPNC

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1261 – 12611By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi689 – 809121cNMP 1Add
    BLAST
    Nucleotide bindingi849 – 969121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. cAMP-dependent protein kinase regulator activity Source: ASPGD
    2. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. asexual sporulation resulting in formation of a cellular spore Source: ASPGD
    2. lipid catabolic process Source: UniProtKB-KW
    3. positive regulation of asexual sporulation resulting in formation of a cellular spore Source: ASPGD
    4. regulation of protein kinase activity Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:An14g03050
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 1R

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular Source: ASPGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15311531Lysophospholipase nte1PRO_0000295311Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00011022.

    Structurei

    3D structure databases

    ProteinModelPortaliA2R350.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272CytoplasmicBy similarityAdd
    BLAST
    Topological domaini94 – 11522LumenalBy similarityAdd
    BLAST
    Topological domaini137 – 15311395CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1228 – 1392165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1259 – 12635GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 614Poly-Pro

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2R350-1 [UniParc]FASTAAdd to Basket

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    MATGDGIIAA PPSLESSSLD PLHVLPASSS TAARSLATSI PALTASFSVV     50
    SGFSSHLPPP PVTPPAPSTM VGWIGWIFSF IFQVIPSVLY WIVTFTTITL 100
    PTWLFTLFSM SLTFTMNFTT LLLIALAVVS TISWFIRYRF LNMYSRLPPE 150
    PQRKEPQLDL FPDVPDSDTK PGLANYLDEF LSAIKVFGYL ERPVFHELTR 200
    TMQTRKLIAG ETLLLEEEKG FCLVVDGLVQ IFVKSMRDRK SGSDEELNRM 250
    AGESSDEDDH RPDGRQGYQL LTEVKNGASM SSLFSILSLF TEDVQLRYAD 300
    SSASSASSIG PGLAIGPDSF PASPREMDDS PHVYQGDRLD PASHRNSTAE 350
    DLPAVPPLNL GESQVPPAHS ARSESRKYSG KTRRKSVHPD IVARAMVDTT 400
    IAIIPASAFR RLTRVYPKAT AHIVQVILTR LQRVTFATAH SYLGLNNEVL 450
    GIEKQMTKFT TYDLPNELRG SALDRLKDKF IKERDRLGQE EVTKGIALHN 500
    PYGGRRPRSS SFRRKEAALQ AKMVASKRPV SMVAQDSALS DRENSGVSPG 550
    DLLSTIQLSR FGPRYEHLAP RLLSPLTEKE HSPLRSPSPM IPGRASPFHR 600
    KESLDEDALF RESILECIMK GIGLTGSTND FLRKSSHPSG DVSPKLLSYD 650
    SRRQKAVFSN NAFGFIDPYE GSADGESESM MSMSVTSAGG TSPIVNLREE 700
    LRNDIEIVYF PQGSVLVEQG ERHPGLYYVV DGFLDVGIPV DDKEEDLVGS 750
    SRPAHEELFP MLRRTNTSSS RVSGSAAAAN DPRRKKQSRR SLYLIKPGGI 800
    QGYVGAVASY RSYTDVVAKT DVYVGFLPRA SLERIAERYP LALLTLAKRL 850
    TSLLPRLLLH IDFALEWVQV SAGQVIYHQG DESDAIYLAL NGRLRSVHEG 900
    PNGKMTVVGE YGQGESVGEL EVMTESTRPA TLHAIRDTEL AKFPRTLFNS 950
    LAQEHPGITI QVSKLIAQRM RDLVETPLAE KGGEPGVSGT VKTAKSTLNL 1000
    RTVGILPVTA GVPVVEFGNR LLQALHQIGV TNGATSLNQA AILNHLGRHA 1050
    FSKMGKLKLS QYLADLEEKY GMVLYIADTS VNSPWTQTCI TQADCILLVG 1100
    LAESTPSIGE YERFLLGMKT TARKELVLLH GERYCPPGLT RQWLKNRVWI 1150
    NGGHHHVQMA FRLTAEPSHP QTKRFGTVLK QRVQVIQAEI QKYTSRRIRQ 1200
    SPLYSAQTPF KGDFHRLARR LCGRSVGLVL GGGGARGIAQ VGVIKALEEA 1250
    GIPIDVIGGT SIGSFIGALY ARDADVVPMY GRAKKFAGRM GSIWRFALDL 1300
    TYPTVSYTTG HEFNRGIFKT FGDSQIEDFW LEFYCNTTNI SRSRAEYHSS 1350
    GYTWRYVRAS MSLAGLIPPI CDEGSMLLDG GYIDNLTVDH MKGLGADVIF 1400
    AVDVGSIDDN TPQVYGDSLS GFWAVVNRWN PFSSCPNPPT LSEIQARLAY 1450
    VSSIENLERA KNTPGCLYMR PPIDPYGTLD FAKFDEIYQL GYAYGKNYLE 1500
    KLKREGSLPL PEETEEKKKL QRTLAPRRAS I 1531
    Length:1,531
    Mass (Da):169,000
    Last modified:July 24, 2007 - v2
    Checksum:i2145CB24C8D6CE79
    GO

    Sequence cautioni

    The sequence CAK46542.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270320 Genomic DNA. Translation: CAK46542.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270320 Genomic DNA. Translation: CAK46542.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali A2R350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00011022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiNTE1_ASPNC
    AccessioniPrimary (citable) accession number: A2R350
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3