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A2R350

- NTE1_ASPNC

UniProt

A2R350 - NTE1_ASPNC

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Protein

Lysophospholipase nte1

Gene
nte1, An14g03050
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1261 – 12611 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi689 – 809121cNMP 1Add
BLAST
Nucleotide bindingi849 – 969121cNMP 2Add
BLAST

GO - Molecular functioni

  1. cAMP-dependent protein kinase regulator activity Source: ASPGD
  2. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. asexual sporulation resulting in formation of a cellular spore Source: ASPGD
  2. lipid catabolic process Source: UniProtKB-KW
  3. positive regulation of asexual sporulation resulting in formation of a cellular spore Source: ASPGD
  4. regulation of protein kinase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:An14g03050
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 1R

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272Cytoplasmic By similarityAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Topological domaini94 – 11522Lumenal By similarityAdd
BLAST
Transmembranei116 – 13621Helical; Reviewed predictionAdd
BLAST
Topological domaini137 – 15311395Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15311531Lysophospholipase nte1PRO_0000295311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00011022.

Structurei

3D structure databases

ProteinModelPortaliA2R350.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1228 – 1392165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1259 – 12635GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 614Poly-Pro

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2R350-1 [UniParc]FASTAAdd to Basket

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MATGDGIIAA PPSLESSSLD PLHVLPASSS TAARSLATSI PALTASFSVV     50
SGFSSHLPPP PVTPPAPSTM VGWIGWIFSF IFQVIPSVLY WIVTFTTITL 100
PTWLFTLFSM SLTFTMNFTT LLLIALAVVS TISWFIRYRF LNMYSRLPPE 150
PQRKEPQLDL FPDVPDSDTK PGLANYLDEF LSAIKVFGYL ERPVFHELTR 200
TMQTRKLIAG ETLLLEEEKG FCLVVDGLVQ IFVKSMRDRK SGSDEELNRM 250
AGESSDEDDH RPDGRQGYQL LTEVKNGASM SSLFSILSLF TEDVQLRYAD 300
SSASSASSIG PGLAIGPDSF PASPREMDDS PHVYQGDRLD PASHRNSTAE 350
DLPAVPPLNL GESQVPPAHS ARSESRKYSG KTRRKSVHPD IVARAMVDTT 400
IAIIPASAFR RLTRVYPKAT AHIVQVILTR LQRVTFATAH SYLGLNNEVL 450
GIEKQMTKFT TYDLPNELRG SALDRLKDKF IKERDRLGQE EVTKGIALHN 500
PYGGRRPRSS SFRRKEAALQ AKMVASKRPV SMVAQDSALS DRENSGVSPG 550
DLLSTIQLSR FGPRYEHLAP RLLSPLTEKE HSPLRSPSPM IPGRASPFHR 600
KESLDEDALF RESILECIMK GIGLTGSTND FLRKSSHPSG DVSPKLLSYD 650
SRRQKAVFSN NAFGFIDPYE GSADGESESM MSMSVTSAGG TSPIVNLREE 700
LRNDIEIVYF PQGSVLVEQG ERHPGLYYVV DGFLDVGIPV DDKEEDLVGS 750
SRPAHEELFP MLRRTNTSSS RVSGSAAAAN DPRRKKQSRR SLYLIKPGGI 800
QGYVGAVASY RSYTDVVAKT DVYVGFLPRA SLERIAERYP LALLTLAKRL 850
TSLLPRLLLH IDFALEWVQV SAGQVIYHQG DESDAIYLAL NGRLRSVHEG 900
PNGKMTVVGE YGQGESVGEL EVMTESTRPA TLHAIRDTEL AKFPRTLFNS 950
LAQEHPGITI QVSKLIAQRM RDLVETPLAE KGGEPGVSGT VKTAKSTLNL 1000
RTVGILPVTA GVPVVEFGNR LLQALHQIGV TNGATSLNQA AILNHLGRHA 1050
FSKMGKLKLS QYLADLEEKY GMVLYIADTS VNSPWTQTCI TQADCILLVG 1100
LAESTPSIGE YERFLLGMKT TARKELVLLH GERYCPPGLT RQWLKNRVWI 1150
NGGHHHVQMA FRLTAEPSHP QTKRFGTVLK QRVQVIQAEI QKYTSRRIRQ 1200
SPLYSAQTPF KGDFHRLARR LCGRSVGLVL GGGGARGIAQ VGVIKALEEA 1250
GIPIDVIGGT SIGSFIGALY ARDADVVPMY GRAKKFAGRM GSIWRFALDL 1300
TYPTVSYTTG HEFNRGIFKT FGDSQIEDFW LEFYCNTTNI SRSRAEYHSS 1350
GYTWRYVRAS MSLAGLIPPI CDEGSMLLDG GYIDNLTVDH MKGLGADVIF 1400
AVDVGSIDDN TPQVYGDSLS GFWAVVNRWN PFSSCPNPPT LSEIQARLAY 1450
VSSIENLERA KNTPGCLYMR PPIDPYGTLD FAKFDEIYQL GYAYGKNYLE 1500
KLKREGSLPL PEETEEKKKL QRTLAPRRAS I 1531
Length:1,531
Mass (Da):169,000
Last modified:July 24, 2007 - v2
Checksum:i2145CB24C8D6CE79
GO

Sequence cautioni

The sequence CAK46542.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270320 Genomic DNA. Translation: CAK46542.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270320 Genomic DNA. Translation: CAK46542.1 . Sequence problems.

3D structure databases

ProteinModelPortali A2R350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00011022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiNTE1_ASPNC
AccessioniPrimary (citable) accession number: A2R350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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