Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1261NucleophilePROSITE-ProRule annotation1
Active sitei1379Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi689 – 809cNMP 1Add BLAST121
Nucleotide bindingi849 – 969cNMP 2Add BLAST121

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:An14g03050
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicBy similarityAdd BLAST72
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 115LumenalBy similarityAdd BLAST22
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 1531CytoplasmicBy similarityAdd BLAST1395

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002953111 – 1531Lysophospholipase nte1Add BLAST1531

Proteomic databases

PaxDbiA2R350
PRIDEiA2R350

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00011022

Structurei

3D structure databases

ProteinModelPortaliA2R350
SMRiA2R350
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1228 – 1392PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1232 – 1237GXGXXGPROSITE-ProRule annotation6
Motifi1259 – 1263GXSXGPROSITE-ProRule annotation5
Motifi1379 – 1381DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 61Poly-Pro4

Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048680
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 5 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit

Sequencei

Sequence statusi: Complete.

A2R350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGDGIIAA PPSLESSSLD PLHVLPASSS TAARSLATSI PALTASFSVV
60 70 80 90 100
SGFSSHLPPP PVTPPAPSTM VGWIGWIFSF IFQVIPSVLY WIVTFTTITL
110 120 130 140 150
PTWLFTLFSM SLTFTMNFTT LLLIALAVVS TISWFIRYRF LNMYSRLPPE
160 170 180 190 200
PQRKEPQLDL FPDVPDSDTK PGLANYLDEF LSAIKVFGYL ERPVFHELTR
210 220 230 240 250
TMQTRKLIAG ETLLLEEEKG FCLVVDGLVQ IFVKSMRDRK SGSDEELNRM
260 270 280 290 300
AGESSDEDDH RPDGRQGYQL LTEVKNGASM SSLFSILSLF TEDVQLRYAD
310 320 330 340 350
SSASSASSIG PGLAIGPDSF PASPREMDDS PHVYQGDRLD PASHRNSTAE
360 370 380 390 400
DLPAVPPLNL GESQVPPAHS ARSESRKYSG KTRRKSVHPD IVARAMVDTT
410 420 430 440 450
IAIIPASAFR RLTRVYPKAT AHIVQVILTR LQRVTFATAH SYLGLNNEVL
460 470 480 490 500
GIEKQMTKFT TYDLPNELRG SALDRLKDKF IKERDRLGQE EVTKGIALHN
510 520 530 540 550
PYGGRRPRSS SFRRKEAALQ AKMVASKRPV SMVAQDSALS DRENSGVSPG
560 570 580 590 600
DLLSTIQLSR FGPRYEHLAP RLLSPLTEKE HSPLRSPSPM IPGRASPFHR
610 620 630 640 650
KESLDEDALF RESILECIMK GIGLTGSTND FLRKSSHPSG DVSPKLLSYD
660 670 680 690 700
SRRQKAVFSN NAFGFIDPYE GSADGESESM MSMSVTSAGG TSPIVNLREE
710 720 730 740 750
LRNDIEIVYF PQGSVLVEQG ERHPGLYYVV DGFLDVGIPV DDKEEDLVGS
760 770 780 790 800
SRPAHEELFP MLRRTNTSSS RVSGSAAAAN DPRRKKQSRR SLYLIKPGGI
810 820 830 840 850
QGYVGAVASY RSYTDVVAKT DVYVGFLPRA SLERIAERYP LALLTLAKRL
860 870 880 890 900
TSLLPRLLLH IDFALEWVQV SAGQVIYHQG DESDAIYLAL NGRLRSVHEG
910 920 930 940 950
PNGKMTVVGE YGQGESVGEL EVMTESTRPA TLHAIRDTEL AKFPRTLFNS
960 970 980 990 1000
LAQEHPGITI QVSKLIAQRM RDLVETPLAE KGGEPGVSGT VKTAKSTLNL
1010 1020 1030 1040 1050
RTVGILPVTA GVPVVEFGNR LLQALHQIGV TNGATSLNQA AILNHLGRHA
1060 1070 1080 1090 1100
FSKMGKLKLS QYLADLEEKY GMVLYIADTS VNSPWTQTCI TQADCILLVG
1110 1120 1130 1140 1150
LAESTPSIGE YERFLLGMKT TARKELVLLH GERYCPPGLT RQWLKNRVWI
1160 1170 1180 1190 1200
NGGHHHVQMA FRLTAEPSHP QTKRFGTVLK QRVQVIQAEI QKYTSRRIRQ
1210 1220 1230 1240 1250
SPLYSAQTPF KGDFHRLARR LCGRSVGLVL GGGGARGIAQ VGVIKALEEA
1260 1270 1280 1290 1300
GIPIDVIGGT SIGSFIGALY ARDADVVPMY GRAKKFAGRM GSIWRFALDL
1310 1320 1330 1340 1350
TYPTVSYTTG HEFNRGIFKT FGDSQIEDFW LEFYCNTTNI SRSRAEYHSS
1360 1370 1380 1390 1400
GYTWRYVRAS MSLAGLIPPI CDEGSMLLDG GYIDNLTVDH MKGLGADVIF
1410 1420 1430 1440 1450
AVDVGSIDDN TPQVYGDSLS GFWAVVNRWN PFSSCPNPPT LSEIQARLAY
1460 1470 1480 1490 1500
VSSIENLERA KNTPGCLYMR PPIDPYGTLD FAKFDEIYQL GYAYGKNYLE
1510 1520 1530
KLKREGSLPL PEETEEKKKL QRTLAPRRAS I
Length:1,531
Mass (Da):169,000
Last modified:July 24, 2007 - v2
Checksum:i2145CB24C8D6CE79
GO

Sequence cautioni

The sequence CAK46542 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270320 Genomic DNA Translation: CAK46542.1 Sequence problems.

Genome annotation databases

EnsemblFungiiCAK46542; CAK46542; An14g03050

Entry informationi

Entry nameiNTE1_ASPNC
AccessioniPrimary (citable) accession number: A2R350
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health