Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A2R350 (NTE1_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:An14g03050
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1531 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence CAK46542.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15311531Lysophospholipase nte1
PRO_0000295311

Regions

Topological domain1 – 7272Cytoplasmic By similarity
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 11522Lumenal By similarity
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 15311395Cytoplasmic By similarity
Domain1228 – 1392165Patatin
Nucleotide binding689 – 809121cNMP 1
Nucleotide binding849 – 969121cNMP 2
Motif1259 – 12635GXSXG
Compositional bias58 – 614Poly-Pro

Sites

Active site12611 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2R350 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 2145CB24C8D6CE79

FASTA1,531169,000
        10         20         30         40         50         60 
MATGDGIIAA PPSLESSSLD PLHVLPASSS TAARSLATSI PALTASFSVV SGFSSHLPPP 

        70         80         90        100        110        120 
PVTPPAPSTM VGWIGWIFSF IFQVIPSVLY WIVTFTTITL PTWLFTLFSM SLTFTMNFTT 

       130        140        150        160        170        180 
LLLIALAVVS TISWFIRYRF LNMYSRLPPE PQRKEPQLDL FPDVPDSDTK PGLANYLDEF 

       190        200        210        220        230        240 
LSAIKVFGYL ERPVFHELTR TMQTRKLIAG ETLLLEEEKG FCLVVDGLVQ IFVKSMRDRK 

       250        260        270        280        290        300 
SGSDEELNRM AGESSDEDDH RPDGRQGYQL LTEVKNGASM SSLFSILSLF TEDVQLRYAD 

       310        320        330        340        350        360 
SSASSASSIG PGLAIGPDSF PASPREMDDS PHVYQGDRLD PASHRNSTAE DLPAVPPLNL 

       370        380        390        400        410        420 
GESQVPPAHS ARSESRKYSG KTRRKSVHPD IVARAMVDTT IAIIPASAFR RLTRVYPKAT 

       430        440        450        460        470        480 
AHIVQVILTR LQRVTFATAH SYLGLNNEVL GIEKQMTKFT TYDLPNELRG SALDRLKDKF 

       490        500        510        520        530        540 
IKERDRLGQE EVTKGIALHN PYGGRRPRSS SFRRKEAALQ AKMVASKRPV SMVAQDSALS 

       550        560        570        580        590        600 
DRENSGVSPG DLLSTIQLSR FGPRYEHLAP RLLSPLTEKE HSPLRSPSPM IPGRASPFHR 

       610        620        630        640        650        660 
KESLDEDALF RESILECIMK GIGLTGSTND FLRKSSHPSG DVSPKLLSYD SRRQKAVFSN 

       670        680        690        700        710        720 
NAFGFIDPYE GSADGESESM MSMSVTSAGG TSPIVNLREE LRNDIEIVYF PQGSVLVEQG 

       730        740        750        760        770        780 
ERHPGLYYVV DGFLDVGIPV DDKEEDLVGS SRPAHEELFP MLRRTNTSSS RVSGSAAAAN 

       790        800        810        820        830        840 
DPRRKKQSRR SLYLIKPGGI QGYVGAVASY RSYTDVVAKT DVYVGFLPRA SLERIAERYP 

       850        860        870        880        890        900 
LALLTLAKRL TSLLPRLLLH IDFALEWVQV SAGQVIYHQG DESDAIYLAL NGRLRSVHEG 

       910        920        930        940        950        960 
PNGKMTVVGE YGQGESVGEL EVMTESTRPA TLHAIRDTEL AKFPRTLFNS LAQEHPGITI 

       970        980        990       1000       1010       1020 
QVSKLIAQRM RDLVETPLAE KGGEPGVSGT VKTAKSTLNL RTVGILPVTA GVPVVEFGNR 

      1030       1040       1050       1060       1070       1080 
LLQALHQIGV TNGATSLNQA AILNHLGRHA FSKMGKLKLS QYLADLEEKY GMVLYIADTS 

      1090       1100       1110       1120       1130       1140 
VNSPWTQTCI TQADCILLVG LAESTPSIGE YERFLLGMKT TARKELVLLH GERYCPPGLT 

      1150       1160       1170       1180       1190       1200 
RQWLKNRVWI NGGHHHVQMA FRLTAEPSHP QTKRFGTVLK QRVQVIQAEI QKYTSRRIRQ 

      1210       1220       1230       1240       1250       1260 
SPLYSAQTPF KGDFHRLARR LCGRSVGLVL GGGGARGIAQ VGVIKALEEA GIPIDVIGGT 

      1270       1280       1290       1300       1310       1320 
SIGSFIGALY ARDADVVPMY GRAKKFAGRM GSIWRFALDL TYPTVSYTTG HEFNRGIFKT 

      1330       1340       1350       1360       1370       1380 
FGDSQIEDFW LEFYCNTTNI SRSRAEYHSS GYTWRYVRAS MSLAGLIPPI CDEGSMLLDG 

      1390       1400       1410       1420       1430       1440 
GYIDNLTVDH MKGLGADVIF AVDVGSIDDN TPQVYGDSLS GFWAVVNRWN PFSSCPNPPT 

      1450       1460       1470       1480       1490       1500 
LSEIQARLAY VSSIENLERA KNTPGCLYMR PPIDPYGTLD FAKFDEIYQL GYAYGKNYLE 

      1510       1520       1530 
KLKREGSLPL PEETEEKKKL QRTLAPRRAS I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270320 Genomic DNA. Translation: CAK46542.1. Sequence problems.

3D structure databases

ProteinModelPortalA2R350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00011022.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ASPNC
AccessionPrimary (citable) accession number: A2R350
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families