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Protein

RNA polymerase II transcription factor B subunit 2

Gene

An14g00480

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:An14g00480Imported
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 1R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiA2R2E7

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00010769

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000170529
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A2R2E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPSSRPF EYLESLAGTV FYKLYQQPST ALAIFRRMLP DLAKCFVMAL
60 70 80 90 100
LYLKDPLPAA DLEAWVKSES LKERDNALSI LGRLHILSNT VTADNVRAYK
110 120 130 140 150
VTDPFATSLR HALTGADQTQ SFGVLSQVPA GSEVSIPELD EYARRQWEGV
160 170 180 190 200
LGYMVGTGGM GGPQVTLSKG VKELLQAGHL VEIRDRRVEI TQDGFAFVLQ
210 220 230 240 250
DVSTQVWHIL ILYVESASAI KMDSVEVLSF VFLLSSLELG KSYEKNHLSS
260 270 280 290 300
KQLRMLTDLA DFGIVYQESP DAPRFYPTRL ATTLTSDSSA LSNPLLGSLS
310 320 330 340 350
GPAGEASSKA GTGFIIIETN YRVYAYTSSP LQISLIALFT TLKYRFPNLI
360 370 380 390 400
TGKITRQSVR RAVEMGITAD QIISYLSTHA HPQMRKHNVS RSTSNQAGIP
410 420 430 440 450
PSVLPPTVVD QIRLWQLERD RVKATSGFLF KDFVSLAEYE APCRYAEEIG
460 470
VLAWKSDRKR MFFVTRHEQV AAFLRSRK
Length:478
Mass (Da):53,120
Last modified:March 6, 2007 - v1
Checksum:iD3280469370EB4D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270309 Genomic DNA Translation: CAK41847.1
RefSeqiXP_001400677.1, XM_001400640.2

Genome annotation databases

EnsemblFungiiCAK41847; CAK41847; An14g00480
GeneIDi4986902
KEGGiang:ANI_1_86124

Similar proteinsi

Entry informationi

Entry nameiA2R2E7_ASPNC
AccessioniPrimary (citable) accession number: A2R2E7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: February 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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