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A2QX52

- EXGD_ASPNC

UniProt

A2QX52 - EXGD_ASPNC

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Protein
Probable glucan 1,3-beta-glucosidase D
Gene
exgD, An11g07660
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971Proton donor By similarity
Active sitei702 – 7021Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:An11g07660
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 7R

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 307307Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei308 – 32821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini329 – 830502Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Probable glucan 1,3-beta-glucosidase D
PRO_0000395165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi376 – 3761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi610 – 6101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi669 – 6691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi689 – 6891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00008917.

Structurei

3D structure databases

ProteinModelPortaliA2QX52.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 8548Asp-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A2QX52-1 [UniParc]FASTAAdd to Basket

« Hide

MPGHSRSRDR LSPSSELDDA DPVYSPSVYQ REHYYNNDSL FDSADDDYTR    50
TPRNVYSYET HDEYHDDDDD DDDVHEHDHD HEYDDKFEEP WVPLRAQVEG 100
DQWREGFETA IPKEEDVTQA KEYQYQMSGA LGDDGPPPLP SDALGRGKGK 150
KRLDRETRRQ RRKERLAAFF KHKNGSASAG LVSGDALAKL LGSQDGDEDC 200
LSHLGTERAD SMSQKNLEGG RQRKLPVLSE EPMMLRPFPA VAPTGQTQGR 250
VVSGAQLEEG GPGMEMRHRG GGGPPAEGLL QKEGDWDGST KGSSTSARPS 300
FWKRYHKTFI FFAILIVLAA IAIPVGIIEA RRLHGTSGGD NSSNSNLKGI 350
SRDSIPAYAR GTYLDPFTWY DTTDFNVTFT NATVGGLSIM GLNSTWNDSA 400
QANENVPPLN EKFPYGSQPI RGVNLGGWLS IEPFIVPSLF DTYTSSEGII 450
DEWTLSEKLG DSAASVIEKH YATFITEQDF ADIRDAGLDH VRIQFSYWAI 500
KTYDGDPYVP KIAWRYLLRA IEYCRKYGLR VNLDPHGIPG SQNGWNHSGR 550
QGTIGWLNGT DGELNRQRSL EMHDQLSQFF AQDRYKNVVT IYGLVNEPLM 600
LSLPVEKVLN WTTEATNLVQ KNGIKAWVTV HDGFLNLDKW DKMLKTRPSN 650
MMLDTHQYTV FNTGEIVLNH TRRVELICES WYSMIQQINI TSTGWGPTIC 700
GEWSQADTDC AQYVNNVGRG TRWEGTFSLT DSTQYCPTAS EGTCSCTQAN 750
AVPGVYSEGY KTFLQTYAEA QMSAFESAMG WFYWTWATES AAQWSYRTAW 800
KNGYMPKKAY SPSFKCGDTI PSFGNLPEYY 830
Length:830
Mass (Da):93,303
Last modified:March 6, 2007 - v1
Checksum:iE07B09114631E566
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270244 Genomic DNA. Translation: CAK45960.1.
RefSeqiXP_001394735.1. XM_001394698.1.

Genome annotation databases

EnsemblFungiiCADANGAT00009088; CADANGAP00008917; CADANGAG00009088.
GeneIDi4984985.
KEGGiang:ANI_1_2268094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270244 Genomic DNA. Translation: CAK45960.1 .
RefSeqi XP_001394735.1. XM_001394698.1.

3D structure databases

ProteinModelPortali A2QX52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00008917.

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00009088 ; CADANGAP00008917 ; CADANGAG00009088 .
GeneIDi 4984985.
KEGGi ang:ANI_1_2268094.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiEXGD_ASPNC
AccessioniPrimary (citable) accession number: A2QX52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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