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A2QX45 (DCL22_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dicer-like protein 2-2

Including the following 2 domains:

  1. Endoribonuclease dcl2-2
    EC=3.1.26.-
  2. ATP-dependent helicase dcl2-2
    EC=3.6.4.-
Gene names
Name:dcl2-2
ORF Names:An11g07590
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Sequence similarities

Belongs to the helicase family. Dicer subfamily.

Contains 1 Dicer dsRNA-binding fold domain.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 2 RNase III domains.

Sequence caution

The sequence CAK40801.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13621362Dicer-like protein 2-2
PRO_0000306788

Regions

Domain30 – 197168Helicase ATP-binding
Domain343 – 505163Helicase C-terminal
Domain536 – 63095Dicer dsRNA-binding fold
Domain889 – 1033145RNase III 1
Domain1075 – 1258184RNase III 2
Nucleotide binding43 – 508ATP By similarity
Motif139 – 1424DEAH box

Sequences

Sequence LengthMass (Da)Tools
A2QX45 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: D233E94793C21EB3

FASTA1,362153,885
        10         20         30         40         50         60 
MTSSTDYHAD STPGTTSNME LRIREYQLEM LNESLKRNLI VVMPTGTGKT QVAILRILAD 

        70         80         90        100        110        120 
IDKGNSDKFV WLLCPTVALS EQQYIQYATV FLPSGAEDKA IWDNALSGIK IAVSTYQVLY 

       130        140        150        160        170        180 
DALSHGFVKL SQMSLLIFDE AHHCKKDHVA NKIMQVHYHK QHQSGVQNLP KILGLTASPI 

       190        200        210        220        230        240 
LSDLSSLEIV ESNLGSICKT PRQYYAQLLQ FTNRPLILPR LPTYTIPNCS VKAPILEKLC 

       250        260        270        280        290        300 
GILSSEDEVP SSSKMKSKQL KHIRRFMQTS ESINQELGIW AATEYMRKSI MHFKESMRMG 

       310        320        330        340        350        360 
AEKTNISNYG KDFAMEILTR LGKLQDCSPA IQPEEISPMC QCLLDELSKA YREGFCGLVF 

       370        380        390        400        410        420 
VTQRATVLAL KWLIENHPLT SHLFTCGTFI GMSTTQYSKT ELGNLHDIRN QTETLEKFRQ 

       430        440        450        460        470        480 
GSLNLIITTD ALEEGIDVPA CNTVLNFNCQ LSLKSFIQRR GRARRENSQF IIIMEDESGP 

       490        500        510        520        530        540 
RYLKRLEMEE IELVQKLQNA ERRQIPANEL DFDKYERISL SLDIDRTGAQ LIMREAVGYL 

       550        560        570        580        590        600 
YNFCSKLPAQ LYVSNKPLFT YERNNYGRFR AVVKLPSNLD PSLQSFSSSR SWSRLKYARE 

       610        620        630        640        650        660 
DAALQAYKAL YQAGLVNDYL VPTQVSDHLE GDIIFRSHYS IQNQLDPWQD IALLWKLDSQ 

       670        680        690        700        710        720 
LYAHNLRIIR PEEDEIHLHM ILPTQLDTTI HIPLFIDYCT TYTAILTPGH PITTDISLCQ 

       730        740        750        760        770        780 
QVTNLIFQSV YRDHCSRRNL DYAFLLVPEL EETKLIEFLE RYSGSVSLTE LLNQEATPSA 

       790        800        810        820        830        840 
LGLLRSHTRP SRPLLVEPWV AGECFLPDEL SISSFDAKVK YMTNRRNFLS HGNLAAGKST 

       850        860        870        880        890        900 
NCEARIGLEA NVKSMSVRDF FVDKLPSMFA QVALFTPSIS HEVEVYMIAQ ILRQELSLRS 

       910        920        930        940        950        960 
VTPWQRIDLL AIAIRPTSIE HRATFRLLAF IGDAFMKYLF AMQLFLHHHL WHEGLLSSLK 

       970        980        990       1000       1010       1020 
QRNLSDAGLA HAIHQSGLGK FLISKHLNGK RWVPPLVSGI EPASNEARQR SIGAATLADM 

      1030       1040       1050       1060       1070       1080 
TKAVVGAAFT DGGLNQAAAC ASVMFPKLKS WNASSLHDGT YSKTRPENAV ASTAIVDMEE 

      1090       1100       1110       1120       1130       1140 
LLGYTFTDKS LAVESMTHPS CTGLVQTTSY RRLSFLGASV LEWIVVSYLH RHAQVMNPQR 

      1150       1160       1170       1180       1190       1200 
MQSLKSAFTN NTFLTFIAIT FHQVREQNHI DVDDEHNVHK NVTTCSIRLW DFLRLHSDAL 

      1210       1220       1230       1240       1250       1260 
STELSDFVQK SSEKADAIKH ELWEQRFYPW VRLRALGDMR VLSDIIQSIF GAVFIDSQAT 

      1270       1280       1290       1300       1310       1320 
LASCDALAEK LGIVPLLEHF ISHQITTDHP KDTLQAILPG RKVSYQICVD KVHPGTLRCS 

      1330       1340       1350       1360 
ALADSSEIAS VEGQMNDEVI KMQAAETAVR LLRKGFALSE TS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270243 Genomic DNA. Translation: CAK40801.1. Sequence problems.

3D structure databases

ProteinModelPortalA2QX45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00008910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1111.
HOGENOMHOG000129941.
OrthoDBEOG76QFRP.

Family and domain databases

Gene3D1.10.1520.10. 3 hits.
3.40.50.300. 2 hits.
InterProIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCL22_ASPNC
AccessionPrimary (citable) accession number: A2QX45
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families