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A2QX45

- DCL22_ASPNC

UniProt

A2QX45 - DCL22_ASPNC

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Protein
Dicer-like protein 2-2
Gene
dcl2-2, An11g07590
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. ribonuclease III activity Source: InterPro

GO - Biological processi

  1. RNA processing Source: InterPro
  2. defense response to virus Source: UniProtKB-KW
  3. regulation of defense response to virus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 2-2
Including the following 2 domains:
Endoribonuclease dcl2-2 (EC:3.1.26.-)
ATP-dependent helicase dcl2-2 (EC:3.6.4.-)
Gene namesi
Name:dcl2-2
ORF Names:An11g07590
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 7R

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13621362Dicer-like protein 2-2
PRO_0000306788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00008910.

Structurei

3D structure databases

ProteinModelPortaliA2QX45.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 197168Helicase ATP-binding
Add
BLAST
Domaini343 – 505163Helicase C-terminal
Add
BLAST
Domaini536 – 63095Dicer dsRNA-binding fold
Add
BLAST
Domaini889 – 1033145RNase III 1
Add
BLAST
Domaini1075 – 1258184RNase III 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1424DEAH box

Sequence similaritiesi

Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000129941.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QX45-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSTDYHAD STPGTTSNME LRIREYQLEM LNESLKRNLI VVMPTGTGKT     50
QVAILRILAD IDKGNSDKFV WLLCPTVALS EQQYIQYATV FLPSGAEDKA 100
IWDNALSGIK IAVSTYQVLY DALSHGFVKL SQMSLLIFDE AHHCKKDHVA 150
NKIMQVHYHK QHQSGVQNLP KILGLTASPI LSDLSSLEIV ESNLGSICKT 200
PRQYYAQLLQ FTNRPLILPR LPTYTIPNCS VKAPILEKLC GILSSEDEVP 250
SSSKMKSKQL KHIRRFMQTS ESINQELGIW AATEYMRKSI MHFKESMRMG 300
AEKTNISNYG KDFAMEILTR LGKLQDCSPA IQPEEISPMC QCLLDELSKA 350
YREGFCGLVF VTQRATVLAL KWLIENHPLT SHLFTCGTFI GMSTTQYSKT 400
ELGNLHDIRN QTETLEKFRQ GSLNLIITTD ALEEGIDVPA CNTVLNFNCQ 450
LSLKSFIQRR GRARRENSQF IIIMEDESGP RYLKRLEMEE IELVQKLQNA 500
ERRQIPANEL DFDKYERISL SLDIDRTGAQ LIMREAVGYL YNFCSKLPAQ 550
LYVSNKPLFT YERNNYGRFR AVVKLPSNLD PSLQSFSSSR SWSRLKYARE 600
DAALQAYKAL YQAGLVNDYL VPTQVSDHLE GDIIFRSHYS IQNQLDPWQD 650
IALLWKLDSQ LYAHNLRIIR PEEDEIHLHM ILPTQLDTTI HIPLFIDYCT 700
TYTAILTPGH PITTDISLCQ QVTNLIFQSV YRDHCSRRNL DYAFLLVPEL 750
EETKLIEFLE RYSGSVSLTE LLNQEATPSA LGLLRSHTRP SRPLLVEPWV 800
AGECFLPDEL SISSFDAKVK YMTNRRNFLS HGNLAAGKST NCEARIGLEA 850
NVKSMSVRDF FVDKLPSMFA QVALFTPSIS HEVEVYMIAQ ILRQELSLRS 900
VTPWQRIDLL AIAIRPTSIE HRATFRLLAF IGDAFMKYLF AMQLFLHHHL 950
WHEGLLSSLK QRNLSDAGLA HAIHQSGLGK FLISKHLNGK RWVPPLVSGI 1000
EPASNEARQR SIGAATLADM TKAVVGAAFT DGGLNQAAAC ASVMFPKLKS 1050
WNASSLHDGT YSKTRPENAV ASTAIVDMEE LLGYTFTDKS LAVESMTHPS 1100
CTGLVQTTSY RRLSFLGASV LEWIVVSYLH RHAQVMNPQR MQSLKSAFTN 1150
NTFLTFIAIT FHQVREQNHI DVDDEHNVHK NVTTCSIRLW DFLRLHSDAL 1200
STELSDFVQK SSEKADAIKH ELWEQRFYPW VRLRALGDMR VLSDIIQSIF 1250
GAVFIDSQAT LASCDALAEK LGIVPLLEHF ISHQITTDHP KDTLQAILPG 1300
RKVSYQICVD KVHPGTLRCS ALADSSEIAS VEGQMNDEVI KMQAAETAVR 1350
LLRKGFALSE TS 1362
Length:1,362
Mass (Da):153,885
Last modified:October 2, 2007 - v2
Checksum:iD233E94793C21EB3
GO

Sequence cautioni

The sequence CAK40801.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270243 Genomic DNA. Translation: CAK40801.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270243 Genomic DNA. Translation: CAK40801.1 . Sequence problems.

3D structure databases

ProteinModelPortali A2QX45.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00008910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000129941.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 3 hits.
3.40.50.300. 2 hits.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiDCL22_ASPNC
AccessioniPrimary (citable) accession number: A2QX45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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