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Protein

Dicer-like protein 2-2

Gene

dcl2-2

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntiviral protein, Helicase, Hydrolase, RNA-binding
Biological processAntiviral defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 2-2
Including the following 2 domains:
Endoribonuclease dcl2-2 (EC:3.1.26.-)
ATP-dependent helicase dcl2-2 (EC:3.6.4.-)
Gene namesi
Name:dcl2-2
ORF Names:An11g07590
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 7R

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003067881 – 1362Dicer-like protein 2-2Add BLAST1362

Proteomic databases

PaxDbiA2QX45
PRIDEiA2QX45

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00008910

Structurei

3D structure databases

ProteinModelPortaliA2QX45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 197Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini343 – 505Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163
Domaini536 – 630Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd BLAST95
Domaini889 – 1033RNase III 1PROSITE-ProRule annotationAdd BLAST145
Domaini1075 – 1258RNase III 2PROSITE-ProRule annotationAdd BLAST184

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 142DEAH box4

Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000129941
OrthoDBiEOG092C02VR

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF69065 SSF69065, 3 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50142 RNASE_3_2, 2 hits

Sequencei

Sequence statusi: Complete.

A2QX45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSTDYHAD STPGTTSNME LRIREYQLEM LNESLKRNLI VVMPTGTGKT
60 70 80 90 100
QVAILRILAD IDKGNSDKFV WLLCPTVALS EQQYIQYATV FLPSGAEDKA
110 120 130 140 150
IWDNALSGIK IAVSTYQVLY DALSHGFVKL SQMSLLIFDE AHHCKKDHVA
160 170 180 190 200
NKIMQVHYHK QHQSGVQNLP KILGLTASPI LSDLSSLEIV ESNLGSICKT
210 220 230 240 250
PRQYYAQLLQ FTNRPLILPR LPTYTIPNCS VKAPILEKLC GILSSEDEVP
260 270 280 290 300
SSSKMKSKQL KHIRRFMQTS ESINQELGIW AATEYMRKSI MHFKESMRMG
310 320 330 340 350
AEKTNISNYG KDFAMEILTR LGKLQDCSPA IQPEEISPMC QCLLDELSKA
360 370 380 390 400
YREGFCGLVF VTQRATVLAL KWLIENHPLT SHLFTCGTFI GMSTTQYSKT
410 420 430 440 450
ELGNLHDIRN QTETLEKFRQ GSLNLIITTD ALEEGIDVPA CNTVLNFNCQ
460 470 480 490 500
LSLKSFIQRR GRARRENSQF IIIMEDESGP RYLKRLEMEE IELVQKLQNA
510 520 530 540 550
ERRQIPANEL DFDKYERISL SLDIDRTGAQ LIMREAVGYL YNFCSKLPAQ
560 570 580 590 600
LYVSNKPLFT YERNNYGRFR AVVKLPSNLD PSLQSFSSSR SWSRLKYARE
610 620 630 640 650
DAALQAYKAL YQAGLVNDYL VPTQVSDHLE GDIIFRSHYS IQNQLDPWQD
660 670 680 690 700
IALLWKLDSQ LYAHNLRIIR PEEDEIHLHM ILPTQLDTTI HIPLFIDYCT
710 720 730 740 750
TYTAILTPGH PITTDISLCQ QVTNLIFQSV YRDHCSRRNL DYAFLLVPEL
760 770 780 790 800
EETKLIEFLE RYSGSVSLTE LLNQEATPSA LGLLRSHTRP SRPLLVEPWV
810 820 830 840 850
AGECFLPDEL SISSFDAKVK YMTNRRNFLS HGNLAAGKST NCEARIGLEA
860 870 880 890 900
NVKSMSVRDF FVDKLPSMFA QVALFTPSIS HEVEVYMIAQ ILRQELSLRS
910 920 930 940 950
VTPWQRIDLL AIAIRPTSIE HRATFRLLAF IGDAFMKYLF AMQLFLHHHL
960 970 980 990 1000
WHEGLLSSLK QRNLSDAGLA HAIHQSGLGK FLISKHLNGK RWVPPLVSGI
1010 1020 1030 1040 1050
EPASNEARQR SIGAATLADM TKAVVGAAFT DGGLNQAAAC ASVMFPKLKS
1060 1070 1080 1090 1100
WNASSLHDGT YSKTRPENAV ASTAIVDMEE LLGYTFTDKS LAVESMTHPS
1110 1120 1130 1140 1150
CTGLVQTTSY RRLSFLGASV LEWIVVSYLH RHAQVMNPQR MQSLKSAFTN
1160 1170 1180 1190 1200
NTFLTFIAIT FHQVREQNHI DVDDEHNVHK NVTTCSIRLW DFLRLHSDAL
1210 1220 1230 1240 1250
STELSDFVQK SSEKADAIKH ELWEQRFYPW VRLRALGDMR VLSDIIQSIF
1260 1270 1280 1290 1300
GAVFIDSQAT LASCDALAEK LGIVPLLEHF ISHQITTDHP KDTLQAILPG
1310 1320 1330 1340 1350
RKVSYQICVD KVHPGTLRCS ALADSSEIAS VEGQMNDEVI KMQAAETAVR
1360
LLRKGFALSE TS
Length:1,362
Mass (Da):153,885
Last modified:October 2, 2007 - v2
Checksum:iD233E94793C21EB3
GO

Sequence cautioni

The sequence CAK40801 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270243 Genomic DNA Translation: CAK40801.1 Sequence problems.

Genome annotation databases

EnsemblFungiiCAK40801; CAK40801; An11g07590

Similar proteinsi

Entry informationi

Entry nameiDCL22_ASPNC
AccessioniPrimary (citable) accession number: A2QX45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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