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A2QX45

- DCL22_ASPNC

UniProt

A2QX45 - DCL22_ASPNC

Protein

Dicer-like protein 2-2

Gene

dcl2-2

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 508ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. ribonuclease III activity Source: InterPro
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. regulation of defense response to virus Source: UniProtKB-KW
    3. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Antiviral protein, Helicase, Hydrolase

    Keywords - Biological processi

    Antiviral defense

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dicer-like protein 2-2
    Including the following 2 domains:
    Endoribonuclease dcl2-2 (EC:3.1.26.-)
    ATP-dependent helicase dcl2-2 (EC:3.6.4.-)
    Gene namesi
    Name:dcl2-2
    ORF Names:An11g07590
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 7R

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13621362Dicer-like protein 2-2PRO_0000306788Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00008910.

    Structurei

    3D structure databases

    ProteinModelPortaliA2QX45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 197168Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini343 – 505163Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini536 – 63095Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd
    BLAST
    Domaini889 – 1033145RNase III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1075 – 1258184RNase III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi139 – 1424DEAH box

    Sequence similaritiesi

    Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation
    Contains 1 Dicer dsRNA-binding fold domain.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 2 RNase III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1111.
    HOGENOMiHOG000129941.
    OrthoDBiEOG76QFRP.

    Family and domain databases

    Gene3Di1.10.1520.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProiIPR005034. Dicer_dimerisation_dom.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF03368. Dicer_dimer. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00636. Ribonuclease_3. 2 hits.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF69065. SSF69065. 3 hits.
    PROSITEiPS51327. DICER_DSRBF. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2QX45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSTDYHAD STPGTTSNME LRIREYQLEM LNESLKRNLI VVMPTGTGKT     50
    QVAILRILAD IDKGNSDKFV WLLCPTVALS EQQYIQYATV FLPSGAEDKA 100
    IWDNALSGIK IAVSTYQVLY DALSHGFVKL SQMSLLIFDE AHHCKKDHVA 150
    NKIMQVHYHK QHQSGVQNLP KILGLTASPI LSDLSSLEIV ESNLGSICKT 200
    PRQYYAQLLQ FTNRPLILPR LPTYTIPNCS VKAPILEKLC GILSSEDEVP 250
    SSSKMKSKQL KHIRRFMQTS ESINQELGIW AATEYMRKSI MHFKESMRMG 300
    AEKTNISNYG KDFAMEILTR LGKLQDCSPA IQPEEISPMC QCLLDELSKA 350
    YREGFCGLVF VTQRATVLAL KWLIENHPLT SHLFTCGTFI GMSTTQYSKT 400
    ELGNLHDIRN QTETLEKFRQ GSLNLIITTD ALEEGIDVPA CNTVLNFNCQ 450
    LSLKSFIQRR GRARRENSQF IIIMEDESGP RYLKRLEMEE IELVQKLQNA 500
    ERRQIPANEL DFDKYERISL SLDIDRTGAQ LIMREAVGYL YNFCSKLPAQ 550
    LYVSNKPLFT YERNNYGRFR AVVKLPSNLD PSLQSFSSSR SWSRLKYARE 600
    DAALQAYKAL YQAGLVNDYL VPTQVSDHLE GDIIFRSHYS IQNQLDPWQD 650
    IALLWKLDSQ LYAHNLRIIR PEEDEIHLHM ILPTQLDTTI HIPLFIDYCT 700
    TYTAILTPGH PITTDISLCQ QVTNLIFQSV YRDHCSRRNL DYAFLLVPEL 750
    EETKLIEFLE RYSGSVSLTE LLNQEATPSA LGLLRSHTRP SRPLLVEPWV 800
    AGECFLPDEL SISSFDAKVK YMTNRRNFLS HGNLAAGKST NCEARIGLEA 850
    NVKSMSVRDF FVDKLPSMFA QVALFTPSIS HEVEVYMIAQ ILRQELSLRS 900
    VTPWQRIDLL AIAIRPTSIE HRATFRLLAF IGDAFMKYLF AMQLFLHHHL 950
    WHEGLLSSLK QRNLSDAGLA HAIHQSGLGK FLISKHLNGK RWVPPLVSGI 1000
    EPASNEARQR SIGAATLADM TKAVVGAAFT DGGLNQAAAC ASVMFPKLKS 1050
    WNASSLHDGT YSKTRPENAV ASTAIVDMEE LLGYTFTDKS LAVESMTHPS 1100
    CTGLVQTTSY RRLSFLGASV LEWIVVSYLH RHAQVMNPQR MQSLKSAFTN 1150
    NTFLTFIAIT FHQVREQNHI DVDDEHNVHK NVTTCSIRLW DFLRLHSDAL 1200
    STELSDFVQK SSEKADAIKH ELWEQRFYPW VRLRALGDMR VLSDIIQSIF 1250
    GAVFIDSQAT LASCDALAEK LGIVPLLEHF ISHQITTDHP KDTLQAILPG 1300
    RKVSYQICVD KVHPGTLRCS ALADSSEIAS VEGQMNDEVI KMQAAETAVR 1350
    LLRKGFALSE TS 1362
    Length:1,362
    Mass (Da):153,885
    Last modified:October 2, 2007 - v2
    Checksum:iD233E94793C21EB3
    GO

    Sequence cautioni

    The sequence CAK40801.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270243 Genomic DNA. Translation: CAK40801.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270243 Genomic DNA. Translation: CAK40801.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali A2QX45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00008910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1111.
    HOGENOMi HOG000129941.
    OrthoDBi EOG76QFRP.

    Family and domain databases

    Gene3Di 1.10.1520.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProi IPR005034. Dicer_dimerisation_dom.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF03368. Dicer_dimer. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00636. Ribonuclease_3. 2 hits.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF69065. SSF69065. 3 hits.
    PROSITEi PS51327. DICER_DSRBF. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiDCL22_ASPNC
    AccessioniPrimary (citable) accession number: A2QX45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3