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Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi: N-glycan degradation

This protein is involved in the pathway N-glycan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway N-glycan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei479Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:An11g06540
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 7R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500022061022 – 931Beta-mannosidase AAdd BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi790N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi798N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi830N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi918N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2QWU9
PRIDEiA2QWU9

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00008814

Structurei

3D structure databases

ProteinModelPortaliA2QWU9
SMRiA2QWU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000216059
OrthoDBiEOG092C0Q54

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QWU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSIGLAAA LLAPTLPVAL GQYIRDLSTE KWTLSSRALN RTVPAQFPSQ
60 70 80 90 100
VHLDLLRAGV IGEYHGLNDF NLRWIAAANW TYTSQPIKGL LDNYDSTWLV
110 120 130 140 150
FDGLDTFATI SFCGQQIAST DNQFRQYAFD VSTALGSCKG DPVLSINFGS
160 170 180 190 200
APNIVDAIAQ DSNSQKWPDD VQLTYEYPNR WFMRKEQSDF GWDWGPAFAP
210 220 230 240 250
AGPWKPAYIV QLDKKESVYV LNTDLDIYRK GQINYLPPDQ SQPWVVNASI
260 270 280 290 300
DILGPLPTKP TMSIEVRDTH SGTILTSRTL NNVSVAGNAI TGVTVLDGLT
310 320 330 340 350
PKLWWPQGLG DQNLYNVSIT VQSRGNQTVA SVNKRTGFRT IFLNQRNITE
360 370 380 390 400
AQRAQGIAPG ANWHFEVNGH EFYAKGSNLI PPDSFWTRVT EEKMSRLFDA
410 420 430 440 450
VVVGNQNMLR VWSSGAYLHD YIYDLADEKG ILLWSEFEFS DALYPSDDAF
460 470 480 490 500
LENVAAEIVY NVRRVNHHPS LALWAGGNEI ESLMLPRVKD AAPSSYSYYV
510 520 530 540 550
GEYEKMYISL FLPLVYENTR SISYSPSSTT EGYLYIDLSA PVPMAERYDN
560 570 580 590 600
TTSGSYYGDT DHYDYDTSVA FDYGSYPVGR FANEFGFHSM PSLQTWQQAV
610 620 630 640 650
DTEDLYFNSS VVMLRNHHDP AGGLMTDNYA NSATGMGEMT MGVVSYYPIP
660 670 680 690 700
SKSDHISNFS AWCHATQLFQ ADMYKSQIQF YRRGSGMPER QLGSLYWQLE
710 720 730 740 750
DIWQAPSWAG IEYGGRWKVL HHVMRDIYQP VIVSPFWNYT TGSLDVYVTS
760 770 780 790 800
DLWSPAAGTV DLTWLDLSGR PIAGNAGTPK SVPFTVGGLN STRIYGTNVS
810 820 830 840 850
SLGLPDTKDA VLILSLSAHG RLPNSDRTTN LTHENYATLS WPKDLKIVDP
860 870 880 890 900
GLKIGHSSKK TTVTVEATSG VSLYTWLDYP EGVVGYFEEN AFVLAPGEKK
910 920 930
EISFTVLEDT TDGAWVRNIT VQSLWDQKVR G
Length:931
Mass (Da):104,026
Last modified:March 6, 2007 - v1
Checksum:iC3D32E4763723612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270241 Genomic DNA Translation: CAK96951.1

Genome annotation databases

EnsemblFungiiCAK96951; CAK96951; An11g06540

Similar proteinsi

Entry informationi

Entry nameiMANBA_ASPNC
AccessioniPrimary (citable) accession number: A2QWU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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