Reviewed, UniProtKB/Swiss-Prot A2QVS9 (MCES_ASPNC)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	abd1
ORF Names:	An11g02520

Organism

Aspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]

Taxonomic identifier

425011 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	mRNA cap guanine-N7 methyltransferase		PRO_0000303903

Sequences

	Sequence		Length	Mass (Da)
	A2QVS9-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: F5B461957EDD37D1	FASTA	609	68,481
	10 20 30 40 50 60 MASKEEERTG QRPSISMYDP ARDRWEEQPV VPAEPASASA SIEATPTQTS EAKPVHDSTV 70 80 90 100 110 120 TSTSESLHLP QTTTIEPSQQ PEQQQKQPPI PTPPSSQSRR KHKINKMGDY YRSGSADAYA 130 140 150 160 170 180 EQSSPAADSH KRKLEDETSE QQPPADQAND RPISKRKRLE ERHQKLRKRG QAPPSAYSRR 190 200 210 220 230 240 DGDETAARAA PRPRSPSPPL PPRSPSPEVQ ARQRKRPGGG ARRGLVDPQT LRRRQEERER 250 260 270 280 290 300 ALEEDAMRNS QSRGVTDIVR QHYNAVPQRG REWRKTESKI KGLRSFNNWV KSTLIQKFSP 310 320 330 340 350 360 DEEFEKRLLV IDLGCGKGGD LGKWQLAPQP VDLYVGLDPA EVSIIQARER YAGMRSGRGP 370 380 390 400 410 420 RGGRRGGPPL FHGEFRSKDC FGEWLGDVDI VQQVGIDPNV GPGGSMMASR WGGGGFDVVT 430 440 450 460 470 480 SMFAIHYAFE SEEKARQMLR NVAGCLKKGG RFIGVCPNSD IISARVEEEA KAEWGNSIYR 490 500 510 520 530 540 VRFPGDTPED GIFRPPFGWK YSYFMEEAVG EIPEYVVPWE AFRALTEEYN LELQYRKPFM 550 560 570 580 590 600 EVWRDEKDDP ELGPLSERMG VRDRTTGELT MTPEEQEAVS KYTPLGFTSA EGESANGTGF YHAFCFYKV

References

[1]

"Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88." Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M. , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H. Nat. Biotechnol. 25:221-231(2007) [PubMed: 17259976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM270225 Genomic DNA. Translation: CAK48318.1.
RefSeq	XP_001394253.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4984482.
KEGG	ang:An11g02520.
Enzyme and pathway databases
BRENDA	2.1.1.56. 277.
Family and domain databases
InterPro	IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MCES_ASPNC

Accession

Primary (citable) accession number: A2QVS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 6, 2007
Last modified:	June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)