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Protein

Serine/threonine-protein kinase ssn3

Gene

ssn3

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70ATPPROSITE-ProRule annotation1
Active sitei172Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 54ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ssn3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:An09g04660
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 1L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129351 – 427Serine/threonine-protein kinase ssn3Add BLAST427

Proteomic databases

PaxDbiA2QU77

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00007858

Structurei

3D structure databases

ProteinModelPortaliA2QU77
SMRiA2QU77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 369Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A2QU77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGRSFPFYN SLGGFYPQSL DARKPPGSGY TSKVRVRDRY HIVGFISSGT
60 70 80 90 100
YGRVYKAIGK NGQKGEFAIK KFKPDKEGEI IQYTGLSQSA IREMALCSEL
110 120 130 140 150
DHPNVVQLAE IILEDKCIFM VFEYTEHDLL QIIHHHTQPQ RHAIPALMVR
160 170 180 190 200
SILFQLLNGL LYLHTNWVLH RDLKPANILV TSSGAIRIGD LGLARLFYKP
210 220 230 240 250
LNSLFSGDKV VVTIWYRAPE LLMGSRHYTP AVDLWAVGCI FAELLSLRPI
260 270 280 290 300
FKGEEAKMDS KKTVPFQRNQ MMKIIEIMGL PTKEIWPGIV SMPEYSQLQS
310 320 330 340 350
LAMSRAPGHF NRSSNLEGWY QSCLKNNGYS ANSSAGTPGA DGFDLLSRLL
360 370 380 390 400
EYDPTKRITA QEALEHPYFK NGGPISANCF EGFEGKYPHR RVTQDDNDIR
410 420
SGSLPGTKRS GLPDDSLLGR ATKRLKE
Length:427
Mass (Da):48,037
Last modified:January 15, 2008 - v2
Checksum:i044C4DA0D2DEE424
GO

Sequence cautioni

The sequence CAK40320 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270202 Genomic DNA Translation: CAK40320.1 Different initiation.

Genome annotation databases

EnsemblFungiiCAK40320; CAK40320; An09g04660

Similar proteinsi

Entry informationi

Entry nameiSSN3_ASPNC
AccessioniPrimary (citable) accession number: A2QU77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health