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A2QU77 (SSN3_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ssn3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:ssn3
Synonyms:cdk8
ORF Names:An09g04660
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAK40320.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Serine/threonine-protein kinase ssn3
PRO_0000312935

Regions

Domain40 – 369330Protein kinase
Nucleotide binding46 – 549ATP By similarity

Sites

Active site1721Proton acceptor By similarity
Binding site701ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QU77 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 044C4DA0D2DEE424

FASTA42748,037
        10         20         30         40         50         60 
MFGRSFPFYN SLGGFYPQSL DARKPPGSGY TSKVRVRDRY HIVGFISSGT YGRVYKAIGK 

        70         80         90        100        110        120 
NGQKGEFAIK KFKPDKEGEI IQYTGLSQSA IREMALCSEL DHPNVVQLAE IILEDKCIFM 

       130        140        150        160        170        180 
VFEYTEHDLL QIIHHHTQPQ RHAIPALMVR SILFQLLNGL LYLHTNWVLH RDLKPANILV 

       190        200        210        220        230        240 
TSSGAIRIGD LGLARLFYKP LNSLFSGDKV VVTIWYRAPE LLMGSRHYTP AVDLWAVGCI 

       250        260        270        280        290        300 
FAELLSLRPI FKGEEAKMDS KKTVPFQRNQ MMKIIEIMGL PTKEIWPGIV SMPEYSQLQS 

       310        320        330        340        350        360 
LAMSRAPGHF NRSSNLEGWY QSCLKNNGYS ANSSAGTPGA DGFDLLSRLL EYDPTKRITA 

       370        380        390        400        410        420 
QEALEHPYFK NGGPISANCF EGFEGKYPHR RVTQDDNDIR SGSLPGTKRS GLPDDSLLGR 


ATKRLKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270202 Genomic DNA. Translation: CAK40320.1. Different initiation.

3D structure databases

ProteinModelPortalA2QU77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00007858.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_ASPNC
AccessionPrimary (citable) accession number: A2QU77
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families