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A2QTN4 (A2QTN4_ASPNC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:An09g02720 EMBL CAK40209.1
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region306 – 3094S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region329 – 33810S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region391 – 3922S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site3551S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
A2QTN4 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 377590381809B001

FASTA50055,943
        10         20         30         40         50         60 
MGFFDHLQKG GAFSLQPKKP QIRKVVQTRT APASRSTSQT PGPSSRTPPA QLKAQQSASR 

        70         80         90        100        110        120 
SVSRDRDPPS AKRRHGTPAQ SRKRQTPELR LSSDDDASDT DSSFEVRKRA RTGDSAEPDP 

       130        140        150        160        170        180 
ARRVRSLKAF SEDSVRSLPM IHAADITSRQ KAGNFKPAFG AAKPLPELLL QYLSTSAPER 

       190        200        210        220        230        240 
YNLVVPRDHD DFKPIDDIVQ VLDIVSQNYI PDEAADEFNN ESTGIKRRLR RALAHLSEAD 

       250        260        270        280        290        300 
FRSVVNEYNE AIVRLRRDGS IAKKLDSTSR LNLPHVERIL NQIYSRTVSP RVESLRQYEN 

       310        320        330        340        350        360 
GTDNVYGELL PRFISTIFKE TGLKSGQVFV DLGSGVGNVV LQAALEIGCE SWGCEMMDNA 

       370        380        390        400        410        420 
CDLADLQQAE FRSRCRLWGI APGKTHLVRG DFLKEQPIID VLKRADVILI NNQAFTPQLN 

       430        440        450        460        470        480 
NELINHFLDM KEGCQIVSLK SFVPAGHKIQ SRNLNSPINL LKVKQRNYWS NSVSWTDVGG 

       490        500 
TYFIATKDSS RLKAFVDSMQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270196 Genomic DNA. Translation: CAK40209.1.
RefSeqXP_001393586.1. XM_001393549.2.

3D structure databases

ProteinModelPortalA2QTN4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00007665.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00007807; CADANGAP00007665; CADANGAG00007807.
GeneID4983805.
KEGGang:ANI_1_296084.

Phylogenomic databases

HOGENOMHOG000176257.
KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA2QTN4_ASPNC
AccessionPrimary (citable) accession number: A2QTN4
Entry history
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)