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A2QTN4

- A2QTN4_ASPNC

UniProt

A2QTN4 - A2QTN4_ASPNC

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

An09g02720

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei355 – 3551S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:An09g02720Imported
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 1L

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00007665.

    Structurei

    3D structure databases

    ProteinModelPortaliA2QTN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni306 – 3094S-adenosyl-L-methionine bindingUniRule annotation
    Regioni329 – 33810S-adenosyl-L-methionine bindingUniRule annotation
    Regioni391 – 3922S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000176257.
    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2QTN4-1 [UniParc]FASTAAdd to Basket

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    MGFFDHLQKG GAFSLQPKKP QIRKVVQTRT APASRSTSQT PGPSSRTPPA    50
    QLKAQQSASR SVSRDRDPPS AKRRHGTPAQ SRKRQTPELR LSSDDDASDT 100
    DSSFEVRKRA RTGDSAEPDP ARRVRSLKAF SEDSVRSLPM IHAADITSRQ 150
    KAGNFKPAFG AAKPLPELLL QYLSTSAPER YNLVVPRDHD DFKPIDDIVQ 200
    VLDIVSQNYI PDEAADEFNN ESTGIKRRLR RALAHLSEAD FRSVVNEYNE 250
    AIVRLRRDGS IAKKLDSTSR LNLPHVERIL NQIYSRTVSP RVESLRQYEN 300
    GTDNVYGELL PRFISTIFKE TGLKSGQVFV DLGSGVGNVV LQAALEIGCE 350
    SWGCEMMDNA CDLADLQQAE FRSRCRLWGI APGKTHLVRG DFLKEQPIID 400
    VLKRADVILI NNQAFTPQLN NELINHFLDM KEGCQIVSLK SFVPAGHKIQ 450
    SRNLNSPINL LKVKQRNYWS NSVSWTDVGG TYFIATKDSS RLKAFVDSMQ 500
    Length:500
    Mass (Da):55,943
    Last modified:March 6, 2007 - v1
    Checksum:i377590381809B001
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270196 Genomic DNA. Translation: CAK40209.1.
    RefSeqiXP_001393586.1. XM_001393549.2.

    Genome annotation databases

    EnsemblFungiiCADANGAT00007807; CADANGAP00007665; CADANGAG00007807.
    GeneIDi4983805.
    KEGGiang:ANI_1_296084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270196 Genomic DNA. Translation: CAK40209.1 .
    RefSeqi XP_001393586.1. XM_001393549.2.

    3D structure databases

    ProteinModelPortali A2QTN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00007665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00007807 ; CADANGAP00007665 ; CADANGAG00007807 .
    GeneIDi 4983805.
    KEGGi ang:ANI_1_296084.

    Phylogenomic databases

    HOGENOMi HOG000176257.
    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513Imported.

    Entry informationi

    Entry nameiA2QTN4_ASPNC
    AccessioniPrimary (citable) accession number: A2QTN4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3