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A2QS05 (NCPR_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH--cytochrome P450 reductase

Short name=CPR
Short name=P450R
EC=1.6.2.4
Gene names
Name:cprA
ORF Names:An08g07840
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis By similarity.

Catalytic activity

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactor

FAD By similarity.

FMN By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Cell membrane; Single-pass membrane protein By similarity. Microsome By similarity.

Sequence similarities

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Contains 1 flavodoxin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695NADPH--cytochrome P450 reductase
PRO_5000220324

Regions

Transmembrane9 – 3123Helical; Potential
Domain66 – 221156Flavodoxin-like
Domain277 – 538262FAD-binding FR-type
Nucleotide binding72 – 765FMN By similarity
Nucleotide binding166 – 19732FMN By similarity
Nucleotide binding317 – 32812FAD By similarity
Nucleotide binding447 – 45812FAD By similarity
Nucleotide binding547 – 56519NADP By similarity
Nucleotide binding642 – 65817NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QS05 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 835324930A8A62F3

FASTA69576,589
        10         20         30         40         50         60 
MAQLDTLDLV VLAVLLVGSV AYFTKGTYWA VAKDPYASTG PAMNGAAKAG KTRNIIEKME 

        70         80         90        100        110        120 
ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD LEEYDYENLD QFPEDKVAFF 

       130        140        150        160        170        180 
VLATYGEGEP TDNAVEFYQF FTGDDVAFES GASADEKPLS KLKYVAFGLG NNTYEHYNAM 

       190        200        210        220        230        240 
VRQVDAAFQK LGAQRIGSAG EGDDGAGTME EDFLAWKEPM WAALSESMDL QEREAVYEPV 

       250        260        270        280        290        300 
FCVTENESLS PEDETVYLGE PTQSHLQGTP KGPYSAHNPF IAPIAESREL FTVKDRNCLH 

       310        320        330        340        350        360 
MEISIAGSNL SYQTGDHIAV WPTNAGAEVD RFLQVFGLEG KRDSVINIKG IDVTAKVPIP 

       370        380        390        400        410        420 
TPTTYDAAVR YYMEVCAPVS RQFVATLAAF APDEESKAEI VRLGSDKDYF HEKVTNQCFN 

       430        440        450        460        470        480 
IAQALQSITS KPFSAVPFSL LIEGITKLQP RYYSISSSSL VQKDKISITA VVESVRLPGA 

       490        500        510        520        530        540 
SHMVKGVTTN YLLALKQKQN GDPSPDPHGL TYSITGPRNK YDGIHVPVHV RHSNFKLPSD 

       550        560        570        580        590        600 
PSRPIIMVGP GTGVAPFRGF IQERAALAAK GEKVGPTVLF FGCRKSDEDF LYKDEWKTYQ 

       610        620        630        640        650        660 
DQLGDNLKII TAFSREGPQK VYVQHRLREH SELVSDLLKQ KATFYVCGDA ANMAREVNLV 

       670        680        690 
LGQIIAAQRG LPAEKGEEMV KHMRSSGSYQ EDVWS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270176 Genomic DNA. Translation: CAK45677.1.
RefSeqXP_001392901.1. XM_001392864.2.

3D structure databases

ProteinModelPortalA2QS05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00006979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00007108; CADANGAP00006979; CADANGAG00007108.
GeneID4983103.
KEGGang:ANI_1_1104074.

Phylogenomic databases

HOGENOMHOG000282027.
KOK00327.
OrthoDBEOG744TKC.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF000208. P450R. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCPR_ASPNC
AccessionPrimary (citable) accession number: A2QS05
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families