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A2QPW5 (KEX1_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:An08g00430
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 612593Pheromone-processing carboxypeptidase kex1
PRO_5000220240

Regions

Topological domain20 – 503484Lumenal Potential
Transmembrane504 – 52421Helical; Potential
Topological domain525 – 61288Cytoplasmic Potential

Sites

Active site1711 By similarity
Active site3701 By similarity
Active site4321 By similarity

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A2QPW5 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 65901439ECFC29C7

FASTA61268,888
        10         20         30         40         50         60 
MASWLLSTLL FLSPSLVSAK SAADYYVHSL PGAPEGPLLK MHAGHIEVDP QNNGNLFFWH 

        70         80         90        100        110        120 
YQNRHIANRQ RTVIWLNGGP GCSSMDGALM EVGPYRLKDN ETLTYNEGSW DEFANLLFVD 

       130        140        150        160        170        180 
QPVGTGFSYV NTDSYLHELD EMSAQFIVFL EEWFRLFPEY ERDDIYIAGE SYAGQHIPYI 

       190        200        210        220        230        240 
AKAIQERNKN VQGKTIASWN LKGLLIGNGW ISPNEQYMSY LPYAYEEGLI KEGSRTAKEL 

       250        260        270        280        290        300 
EVLQSVCKSR LETGKNKVHL NDCEKVMNAL LDKTVEDNKC LNMYDIRLRD TTDACGMNWP 

       310        320        330        340        350        360 
TDLEDVKPYL QREDVVKALN INPEKKSGWV ECSGAVSSAF NPQKSPPSVQ LLPGLLESGL 

       370        380        390        400        410        420 
QILLFSGDKD LICNHVGTEQ LINNMKWNGG TGFETSPGVW APRHDWSFEG EPAGIYQYAR 

       430        440        450        460        470        480 
NLTYVLIYNA SHMVPYDLPR QSRDMLDRFM NVDIASIGGS PADSRIDGEK LPQTSVGGHP 

       490        500        510        520        530        540 
NSTAAEEQEK ERIKETEWKA YAKSGEAVLL VVIIGVLVWG FFIWRSRRRH QGYRGVWHKD 

       550        560        570        580        590        600 
MSGSSVLERF HNKRTGGADV EAGDFDEAEL DDLHSPDLER EHYAVGEDSD EDDISRQHSQ 

       610 
QASRAGGSHN LS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270157 Genomic DNA. Translation: CAK45195.1.

3D structure databases

ProteinModelPortalA2QPW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00006239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00006362; CADANGAP00006239; CADANGAG00006362.

Phylogenomic databases

HOGENOMHOG000208879.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ASPNC
AccessionPrimary (citable) accession number: A2QPW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries