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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171By similarity1
Active sitei370By similarity1
Active sitei432By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:An08g00430
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 8R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 503LumenalSequence analysisAdd BLAST484
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 612CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500022024020 – 612Pheromone-processing carboxypeptidase kex1Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2QPW5
PRIDEiA2QPW5

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00006239

Structurei

3D structure databases

ProteinModelPortaliA2QPW5
SMRiA2QPW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QPW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASWLLSTLL FLSPSLVSAK SAADYYVHSL PGAPEGPLLK MHAGHIEVDP
60 70 80 90 100
QNNGNLFFWH YQNRHIANRQ RTVIWLNGGP GCSSMDGALM EVGPYRLKDN
110 120 130 140 150
ETLTYNEGSW DEFANLLFVD QPVGTGFSYV NTDSYLHELD EMSAQFIVFL
160 170 180 190 200
EEWFRLFPEY ERDDIYIAGE SYAGQHIPYI AKAIQERNKN VQGKTIASWN
210 220 230 240 250
LKGLLIGNGW ISPNEQYMSY LPYAYEEGLI KEGSRTAKEL EVLQSVCKSR
260 270 280 290 300
LETGKNKVHL NDCEKVMNAL LDKTVEDNKC LNMYDIRLRD TTDACGMNWP
310 320 330 340 350
TDLEDVKPYL QREDVVKALN INPEKKSGWV ECSGAVSSAF NPQKSPPSVQ
360 370 380 390 400
LLPGLLESGL QILLFSGDKD LICNHVGTEQ LINNMKWNGG TGFETSPGVW
410 420 430 440 450
APRHDWSFEG EPAGIYQYAR NLTYVLIYNA SHMVPYDLPR QSRDMLDRFM
460 470 480 490 500
NVDIASIGGS PADSRIDGEK LPQTSVGGHP NSTAAEEQEK ERIKETEWKA
510 520 530 540 550
YAKSGEAVLL VVIIGVLVWG FFIWRSRRRH QGYRGVWHKD MSGSSVLERF
560 570 580 590 600
HNKRTGGADV EAGDFDEAEL DDLHSPDLER EHYAVGEDSD EDDISRQHSQ
610
QASRAGGSHN LS
Length:612
Mass (Da):68,888
Last modified:March 6, 2007 - v1
Checksum:i65901439ECFC29C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270157 Genomic DNA Translation: CAK45195.1

Genome annotation databases

EnsemblFungiiCAK45195; CAK45195; An08g00430

Similar proteinsi

Entry informationi

Entry nameiKEX1_ASPNC
AccessioniPrimary (citable) accession number: A2QPW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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