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A2QN74

- BTGC_ASPNC

UniProt

A2QN74 - BTGC_ASPNC

Protein

Putative glucan endo-1,3-beta-glucosidase btgC

Gene

btgC

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei586 – 5861NucleophileBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH17. Glycoside Hydrolase Family 17.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glucan endo-1,3-beta-glucosidase btgC (EC:3.2.1.39)
    Alternative name(s):
    Endo-1,3-beta-glucanase btgC
    Laminarinase btgC
    Gene namesi
    Name:btgC
    ORF Names:An07g04650
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 4L

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Putative glucan endo-1,3-beta-glucosidase btgCPRO_0000395125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 302302CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 684361ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei303 – 32321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi245 – 358114Gly-richAdd
    BLAST
    Compositional biasi337 – 34610Poly-Ser

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 17 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5309.
    HOGENOMiHOG000173877.
    OrthoDBiEOG7P8PHC.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2QN74-1 [UniParc]FASTAAdd to Basket

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    MAGVNRSFSY SRGDDALLRD DEREISPLRS AEDGLYSTSY GDVSPLSAGV    50
    QAQNRPFDRG LVSVPEGQTL ERHMTSTPGM DNLGPASVGG GISGIALGVA 100
    NSHNRQSGVD AFRETDVPVR NLPAERDFNT TGSDNPYIPA PPDGDIYPSS 150
    EAVRYRDSYS SHTGLGAGAP FAEHSTPGTT PSQRSFFDSP YQGVDAGPYQ 200
    RHSAYSSHDY PLVINPDDIA DDGDDGFPVH PKGAADYRSN ANVPGTGVAG 250
    AAAAGGFLGK FRALFKREEP SPFYDSDIGG GLGGAEKAQG GRHIIGGGSR 300
    KRGWIVGLIL AAVIVAAIVG GAVGGILGHQ EHDGDTSSSS SSSSSSGTGS 350
    GGSDKGDGLL DKDSDEIKAL MNNKNLHKVF PGVDYTPWGV QYPLCLQYPP 400
    SQNNVTRDLA VLTQLTNTIR LYGTDCNQTE MVLEAIDRLQ LTNMKLWLGV 450
    WIDTNTTTTD RQISQLYKIV ENANDTSIFK GAIVGNEALY RAGSDVASAE 500
    TNLIGYINDV KDHFKDKNID LPVGTSDLGD NWNAQLVSAA DFVMSNIHPF 550
    FGGVEIDDAA SWTWTFWQTH DTPLTAGTNK QQIISEVGWP TGGGNDCGSD 600
    NKCQNDKQGA VAGIDELNQF LSEWVCQALD NGTEYFWFEA FDEPWKVQYN 650
    TPGQEWEDKW GLMDSARNLK PGVKIPDCGG KTIT 684
    Length:684
    Mass (Da):73,248
    Last modified:June 15, 2010 - v2
    Checksum:i5CB65C56222424D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270130 Genomic DNA. Translation: CAK39383.1.
    RefSeqiXP_001391547.2. XM_001391510.2.

    Genome annotation databases

    GeneIDi4981731.
    KEGGiang:ANI_1_1742064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270130 Genomic DNA. Translation: CAK39383.1 .
    RefSeqi XP_001391547.2. XM_001391510.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH17. Glycoside Hydrolase Family 17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4981731.
    KEGGi ang:ANI_1_1742064.

    Phylogenomic databases

    eggNOGi COG5309.
    HOGENOMi HOG000173877.
    OrthoDBi EOG7P8PHC.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiBTGC_ASPNC
    AccessioniPrimary (citable) accession number: A2QN74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the conserved Glu residue in position 619 essential for glucanase activity. Its enzyme activity is therefore unsure.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3