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A2QN74 (BTGC_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glucan endo-1,3-beta-glucosidase btgC

EC=3.2.1.39
Alternative name(s):
Endo-1,3-beta-glucanase btgC
Laminarinase btgC
Gene names
Name:btgC
ORF Names:An07g04650
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan By similarity.

Catalytic activity

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 17 family.

Caution

Lacks the conserved Glu residue in position 619 essential for glucanase activity. Its enzyme activity is therefore unsure.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 684684Putative glucan endo-1,3-beta-glucosidase btgC
PRO_0000395125

Regions

Topological domain1 – 302302Cytoplasmic Potential
Transmembrane303 – 32321Helical; Signal-anchor for type II membrane protein; Potential
Topological domain324 – 684361Extracellular Potential
Compositional bias245 – 358114Gly-rich
Compositional bias337 – 34610Poly-Ser

Sites

Active site5861Nucleophile By similarity

Amino acid modifications

Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A2QN74 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: 5CB65C56222424D0

FASTA68473,248
        10         20         30         40         50         60 
MAGVNRSFSY SRGDDALLRD DEREISPLRS AEDGLYSTSY GDVSPLSAGV QAQNRPFDRG 

        70         80         90        100        110        120 
LVSVPEGQTL ERHMTSTPGM DNLGPASVGG GISGIALGVA NSHNRQSGVD AFRETDVPVR 

       130        140        150        160        170        180 
NLPAERDFNT TGSDNPYIPA PPDGDIYPSS EAVRYRDSYS SHTGLGAGAP FAEHSTPGTT 

       190        200        210        220        230        240 
PSQRSFFDSP YQGVDAGPYQ RHSAYSSHDY PLVINPDDIA DDGDDGFPVH PKGAADYRSN 

       250        260        270        280        290        300 
ANVPGTGVAG AAAAGGFLGK FRALFKREEP SPFYDSDIGG GLGGAEKAQG GRHIIGGGSR 

       310        320        330        340        350        360 
KRGWIVGLIL AAVIVAAIVG GAVGGILGHQ EHDGDTSSSS SSSSSSGTGS GGSDKGDGLL 

       370        380        390        400        410        420 
DKDSDEIKAL MNNKNLHKVF PGVDYTPWGV QYPLCLQYPP SQNNVTRDLA VLTQLTNTIR 

       430        440        450        460        470        480 
LYGTDCNQTE MVLEAIDRLQ LTNMKLWLGV WIDTNTTTTD RQISQLYKIV ENANDTSIFK 

       490        500        510        520        530        540 
GAIVGNEALY RAGSDVASAE TNLIGYINDV KDHFKDKNID LPVGTSDLGD NWNAQLVSAA 

       550        560        570        580        590        600 
DFVMSNIHPF FGGVEIDDAA SWTWTFWQTH DTPLTAGTNK QQIISEVGWP TGGGNDCGSD 

       610        620        630        640        650        660 
NKCQNDKQGA VAGIDELNQF LSEWVCQALD NGTEYFWFEA FDEPWKVQYN TPGQEWEDKW 

       670        680 
GLMDSARNLK PGVKIPDCGG KTIT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270130 Genomic DNA. Translation: CAK39383.1.
RefSeqXP_001391547.2. XM_001391510.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH17. Glycoside Hydrolase Family 17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4981731.
KEGGang:ANI_1_1742064.

Phylogenomic databases

eggNOGCOG5309.
HOGENOMHOG000173877.
OrthoDBEOG7P8PHC.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBTGC_ASPNC
AccessionPrimary (citable) accession number: A2QN74
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 19, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries