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A2QN07 (MPKC_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkC
ORF Names:An07g03980
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Mitogen-activated protein kinase mpkC
PRO_0000289714

Regions

Domain20 – 299280Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif171 – 1733TXY

Sites

Active site1411Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1711Phosphothreonine By similarity
Modified residue1731Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QN07 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: F13BC0AF8E53FF13

FASTA39645,038
        10         20         30         40         50         60 
MAEFLRSQIL GTTFETTNRY SDLQPVGLGA FGLVCSAYDM ITRQPVAIKK MMKPFSNATL 

        70         80         90        100        110        120 
AKRTYREVKL LKHLRHENLI GLSDIFISPL EDVYLVTDLL GTDLNRLLTS KPLDGKFVQY 

       130        140        150        160        170        180 
FTYQLLRGLK YIHSAGVIHR DLKPSNILIN ENCDLKICDF GLARLQEPQM TGYVSTRYYR 

       190        200        210        220        230        240 
APEIMLTWQK YGMQVDIWSA GCIVAEMLRG KPLFPGKDHI NQFFLITDAL GNPPDEVIER 

       250        260        270        280        290        300 
ICTKTTLDLV KSLPKRQPAP WATLFPDSDE NAIDLLGEML IFDPDKRISA AKALEHPYLS 

       310        320        330        340        350        360 
VYHDPTDEPV AEQMFDWSFS EVAHSIDEWK IMIYTEVVDF HDIGPTEEPV ITEPFLSPDP 

       370        380        390 
SLSPEVLDPL GQIQTQSMVT KSAETLDQDI LQYLQI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270128 Genomic DNA. Translation: CAK48148.1.
RefSeqXP_001391480.1. XM_001391443.2.

3D structure databases

ProteinModelPortalA2QN07.
SMRA2QN07. Positions 3-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00005558.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005669; CADANGAP00005558; CADANGAG00005669.
GeneID4981664.
KEGGang:ANI_1_492064.

Phylogenomic databases

HOGENOMHOG000233024.
KOK04441.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_ASPNC
AccessionPrimary (citable) accession number: A2QN07
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families