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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Copper; catalyticBy similarity1
Metal bindingi49Copper; catalyticBy similarity1
Metal bindingi64Copper; catalyticBy similarity1
Metal bindingi64Zinc; structuralBy similarity1
Metal bindingi72Zinc; structuralBy similarity1
Metal bindingi81Zinc; structuralBy similarity1
Metal bindingi84Zinc; structuralBy similarity1
Metal bindingi121Copper; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]By similarity (EC:1.15.1.1)
Gene namesi
Name:sodCBy similarity
ORF Names:An07g03770
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 4L

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003551002 – 154Superoxide dismutase [Cu-Zn]By similarityAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2QMY6
PRIDEiA2QMY6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00005537

Structurei

3D structure databases

ProteinModelPortaliA2QMY6
SMRiA2QMY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000263447
KOiK04565
OrthoDBiEOG092C578I

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QMY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVAVIRG DSKVSGTVTF EQANENTPTT ISWNITGHDA NAERGFHVHQ
60 70 80 90 100
FGDNTNGCTS AGPHFNPFGK THGAPEDDER HVGDLGNFKT DAEGNAVGSK
110 120 130 140 150
QDKLVKLIGA ESVLGRTLVV HAGTDDLGRG GNEESKKTGN AGPRPACGVI

GIAA
Length:154
Mass (Da):15,960
Last modified:March 6, 2007 - v1
Checksum:iC8679562F6FB52AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270128 Genomic DNA Translation: CAK48127.1
RefSeqiXP_001391459.1, XM_001391422.2

Genome annotation databases

EnsemblFungiiCAK48127; CAK48127; An07g03770
GeneIDi4981643
KEGGiang:ANI_1_470064

Similar proteinsi

Entry informationi

Entry nameiSODC_ASPNC
AccessioniPrimary (citable) accession number: A2QMY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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