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A2QMS4 (XKS1_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable D-xylulose kinase A

Short name=Xylulokinase A
EC=2.7.1.17
Gene names
Name:xkiA
ORF Names:An07g03140
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Subcellular location

Cytoplasm By similarity.

Induction

By D-xylose, L-arabinose or L-arabitol.

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Xylose metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylulokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Probable D-xylulose kinase A
PRO_0000393520

Regions

Nucleotide binding469 – 4702ATP By similarity

Sites

Binding site951Substrate By similarity
Binding site1661Substrate By similarity
Binding site2821Substrate By similarity
Binding site2831Substrate By similarity
Binding site3641ATP By similarity
Binding site4731ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QMS4 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: DB30560DD5868E86

FASTA57062,762
        10         20         30         40         50         60 
MQGPLYIGFD LSTQQLKGLV VNSDLKVVYV SKFDFDADSH GFPIKKGVLT NEAEHEVFAP 

        70         80         90        100        110        120 
VALWLQALDG VLEGLRKQGM DFSQIKGISG AGQQHGSVYW GENAEKLLKE LDASKTLEEQ 

       130        140        150        160        170        180 
LDGAFSHPFS PNWQDSSTQK ECDEFDAALG GQSELAFATG SKAHHRFTGP QIMRFQRKYP 

       190        200        210        220        230        240 
DVYKKTSRIS LVSSFIASLF LGHIAPMDIS DVCGMNLWNI KKGAYDEKLL QLCAGSSGVD 

       250        260        270        280        290        300 
DLKRKLGDVP EDGGIHLGPI DRYYVERYGF SPDCTIIPAT GDNPATILAL PLRASDAMVS 

       310        320        330        340        350        360 
LGTSTTFLMS TPSYKPDPAT HFFNHPTTAG LYMFMLCYKN GGLARELVRD AVNEKLGEKP 

       370        380        390        400        410        420 
STSWANFDKV TLETPPMGQK ADSDPMKLGL FFPRPEIVPN LRSGQWRFDY NPKDGSLQPS 

       430        440        450        460        470        480 
NGGWDEPFDE ARAIVESQML SLRLRSRGLT QSPGEGIPAQ PRRVYLVGGG SKNKAIAKVA 

       490        500        510        520        530        540 
GEILGGSEGV YKLEIGDNAC ALGAAYKAVW AMERAEGQTF EDLIGKRWHE EEFIEKIADG 

       550        560        570 
YQPGVFERYG QAAEGFEKME LEVLRQEGKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270126 Genomic DNA. Translation: CAL00248.1.
RefSeqXP_001391397.1. XM_001391360.2.

3D structure databases

ProteinModelPortalA2QMS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00005475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005586; CADANGAP00005475; CADANGAG00005586.
GeneID4981581.
KEGGang:ANI_1_1644064.

Phylogenomic databases

HOGENOMHOG000174850.
KOK00854.
OrthoDBEOG7CRTZN.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXKS1_ASPNC
AccessionPrimary (citable) accession number: A2QMS4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families