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A2QMS4

- XKS1_ASPNC

UniProt

A2QMS4 - XKS1_ASPNC

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Protein
Probable D-xylulose kinase A
Gene
xkiA, An07g03140
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei364 – 3641ATP By similarity
Binding sitei473 – 4731ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi469 – 4702ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:An07g03140
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 4L

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Probable D-xylulose kinase A
PRO_0000393520Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00005475.

Structurei

3D structure databases

ProteinModelPortaliA2QMS4.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

HOGENOMiHOG000174850.
KOiK00854.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QMS4-1 [UniParc]FASTAAdd to Basket

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MQGPLYIGFD LSTQQLKGLV VNSDLKVVYV SKFDFDADSH GFPIKKGVLT    50
NEAEHEVFAP VALWLQALDG VLEGLRKQGM DFSQIKGISG AGQQHGSVYW 100
GENAEKLLKE LDASKTLEEQ LDGAFSHPFS PNWQDSSTQK ECDEFDAALG 150
GQSELAFATG SKAHHRFTGP QIMRFQRKYP DVYKKTSRIS LVSSFIASLF 200
LGHIAPMDIS DVCGMNLWNI KKGAYDEKLL QLCAGSSGVD DLKRKLGDVP 250
EDGGIHLGPI DRYYVERYGF SPDCTIIPAT GDNPATILAL PLRASDAMVS 300
LGTSTTFLMS TPSYKPDPAT HFFNHPTTAG LYMFMLCYKN GGLARELVRD 350
AVNEKLGEKP STSWANFDKV TLETPPMGQK ADSDPMKLGL FFPRPEIVPN 400
LRSGQWRFDY NPKDGSLQPS NGGWDEPFDE ARAIVESQML SLRLRSRGLT 450
QSPGEGIPAQ PRRVYLVGGG SKNKAIAKVA GEILGGSEGV YKLEIGDNAC 500
ALGAAYKAVW AMERAEGQTF EDLIGKRWHE EEFIEKIADG YQPGVFERYG 550
QAAEGFEKME LEVLRQEGKH 570
Length:570
Mass (Da):62,762
Last modified:March 6, 2007 - v1
Checksum:iDB30560DD5868E86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270126 Genomic DNA. Translation: CAL00248.1.
RefSeqiXP_001391397.1. XM_001391360.2.

Genome annotation databases

EnsemblFungiiCADANGAT00005586; CADANGAP00005475; CADANGAG00005586.
GeneIDi4981581.
KEGGiang:ANI_1_1644064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270126 Genomic DNA. Translation: CAL00248.1 .
RefSeqi XP_001391397.1. XM_001391360.2.

3D structure databases

ProteinModelPortali A2QMS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00005475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00005586 ; CADANGAP00005475 ; CADANGAG00005586 .
GeneIDi 4981581.
KEGGi ang:ANI_1_1644064.

Phylogenomic databases

HOGENOMi HOG000174850.
KOi K00854.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiXKS1_ASPNC
AccessioniPrimary (citable) accession number: A2QMS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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