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A2QM49 (LCPS_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:An07g00800
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409232

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane99 – 12123Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane242 – 26221Helical; Potential
Region1 – 261261Lycopene beta-cyclase
Region268 – 582315Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
A2QM49 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 88E8322BC29400BA

FASTA58265,647
        10         20         30         40         50         60 
MNQNGTRLCY SVREVPPTSF VSAPANYKRA SSHCTYTIPA ASALTVLYYP FFTAQDRCKI 

        70         80         90        100        110        120 
CILITIAILA TLPWDSYLIR SAIWTYPPDA VVGLKILDIP IEEVFFFAIQ TYITSLTYCI 

       130        140        150        160        170        180 
FTKPLVRPMY LRSHLERRGT RYVVATVILA LMGGGTACLL LGRRMTYLGL ILVWACPILL 

       190        200        210        220        230        240 
FQWMMSYPFL SELPWKPTIT SICLPTLHLW FADSRAMGTG TWRIEEGTKL NFRIGGLELE 

       250        260        270        280        290        300 
EALFFLVSNM MVVLGLVGCD YAYALQEYES LSQPASDVYI TLRKALSLLA RPLPIDASLI 

       310        320        330        340        350        360 
SALSQAVYRL QEKSQSMFLG SALFQGQLRI DLIFLYSFCR VMDDLIDEAE DEQEARFWVT 

       370        380        390        400        410        420 
ECRHLLDSTH RSEPHSDHFY TGKKGEEHER LRQSISYLPP SHLSNDSFDD LLKGFEIDLK 

       430        440        450        460        470        480 
FNPQREAFPI QSEYCLDQYA GFVAGTVGVL VFDLTLFHCG HYFIQDVPRL RRAAKDMGKA 

       490        500        510        520        530        540 
MQCQPRGDGG ATSGRKRAIA GNRGELYGYW TTAEGAERHK PGASVEDEGA FGATAKSWLA 

       550        560        570        580 
GDVITELCHC FIQAEYVIYL VRHQNASADT LVLLSALVYR LE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270119 Genomic DNA. Translation: CAK39303.1.

3D structure databases

ProteinModelPortalA2QM49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00005250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005357; CADANGAP00005250; CADANGAG00005357.

Phylogenomic databases

eggNOGNOG47964.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
ProtoNetSearch...

Entry information

Entry nameLCPS_ASPNC
AccessionPrimary (citable) accession number: A2QM49
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 6, 2007
Last modified: March 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways