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Protein

1,3-beta-glucan synthase component FKS1

Gene

fksA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic subunit of the 1,3-beta-glucan synthase. Synthesizes 1,3-beta-glucan, a major structural component of the cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling (By similarity).By similarity

Catalytic activityi

UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGT48. Glycosyltransferase Family 48.

Names & Taxonomyi

Protein namesi
Recommended name:
1,3-beta-glucan synthase component FKS1 (EC:2.4.1.34)
Alternative name(s):
1,3-beta-D-glucan-UDP glucosyltransferase
Gene namesi
Name:fksA1 Publication
Synonyms:fks1By similarity
ORF Names:An06g01550
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 8ER

Organism-specific databases

EuPathDBiFungiDB:An06g01550.

Subcellular locationi

  • Mitochondrion
  • Cell membrane Sequence analysisBy similarity; Multi-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 50721HelicalSequence analysisAdd
BLAST
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST
Transmembranei564 – 58421HelicalSequence analysisAdd
BLAST
Transmembranei591 – 61121HelicalSequence analysisAdd
BLAST
Transmembranei655 – 67521HelicalSequence analysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence analysisAdd
BLAST
Transmembranei728 – 74821HelicalSequence analysisAdd
BLAST
Transmembranei1329 – 134921HelicalSequence analysisAdd
BLAST
Transmembranei1386 – 140621HelicalSequence analysisAdd
BLAST
Transmembranei1473 – 149321HelicalSequence analysisAdd
BLAST
Transmembranei1497 – 151721HelicalSequence analysisAdd
BLAST
Transmembranei1588 – 160821HelicalSequence analysisAdd
BLAST
Transmembranei1630 – 165021HelicalSequence analysisAdd
BLAST
Transmembranei1666 – 168621HelicalSequence analysisAdd
BLAST
Transmembranei1701 – 172121HelicalSequence analysisAdd
BLAST
Transmembranei1766 – 178621HelicalSequence analysisAdd
BLAST
Transmembranei1826 – 184621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry

DrugBankiDB00362. Anidulafungin.
DB00520. Caspofungin.
DB01141. Micafungin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189718971,3-beta-glucan synthase component FKS1PRO_0000322581Add
BLAST

Interactioni

Subunit structurei

Component of the 1,3-beta-glucan synthase, composed of at least catalytic subunit fksA, and a regulatory subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2QLK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 7875Tyr-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 48 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000216604.
KOiK00706.
OrthoDBiEOG092C025F.

Family and domain databases

InterProiIPR026899. FKS1-like_dom1.
IPR003440. Glyco_trans_48.
[Graphical view]
PfamiPF14288. FKS1_dom1. 1 hit.
PF02364. Glucan_synthase. 1 hit.
[Graphical view]
SMARTiSM01205. FKS1_dom1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QLK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYPAGHYE DGYGHQEHGG DAYYQDEHGQ AYYDPNDYGD SYYDRGNYYN
60 70 80 90 100
AEGGQAYGQE GGYYDAGHQD DYYGDQYYDQ GNGAPRGRRR GDSEEDSETF
110 120 130 140 150
SDFTMRSETA RAADMDYYGR GDERYNSYAD SQYAGRGYNG YRPPSSQVSY
160 170 180 190 200
GANRSSGAST PVYGMDYGSA LPGGPRSREP YPAWASDGQV PVSKEEIEDI
210 220 230 240 250
FIDLVNKFGF QRDSMRNMYD HLMTQLDSRA SRMTPNQALL SLHADYIGGD
260 270 280 290 300
NANYRRWYFA AHLDLDDAVG FANMKLGKAD RKTRKARKAA KAAAQQNPEN
310 320 330 340 350
VEENLEAMEG DNSLEAAVYR WKSRMNRMSP HDRVRQLALY MLCWGEANQV
360 370 380 390 400
RYMPECICFI FKCADDYYSS PECQSRVEPV EEFTYLNEII TPLYQFCRDQ
410 420 430 440 450
GYEILDGKYV RRERDHEKII GYDDMNQLFW YPEGIERISF EDKTRLVDVP
460 470 480 490 500
PAERWTKLKD VDWKKAFFKT YRETRSWFHM ITNFNRIWVI HLGAFWFFTA
510 520 530 540 550
YNAPTLYTKN YQQQLDNKPA GSKYWSAVGF GGALVGLIQI LATLCEWMYV
560 570 580 590 600
PRRWAGAQHL SKRLMFLIAV FIVNLAPGVV VFGFNNVLSE TICLIIGIVH
610 620 630 640 650
FFIALATFFF FSVMPLGGLF GSYLKKHGRQ YVASQTFTAS YPRLNGNDMW
660 670 680 690 700
MSYGLWICVF GAKLVESYFF LTLSLKDPMR ILSPMRIHQC AGVTYIPNSL
710 720 730 740 750
CHAQPQILLG LMMFMDLTLF FLDSYLWYVI CNTIFSVARS FYLGVSIWSP
760 770 780 790 800
WRNIFSRLPK RIYSKVLATT DMEIKYKPKV LISQVWNAII ISMYREHLLA
810 820 830 840 850
IDHVQKLLYH QVPSEQEGKR TLRAPTFFVS QEDQSFKTEF FPAGSEAERR
860 870 880 890 900
ISFFAQSVAT PMPEPLPVDN MPTFTVLIPH YGEKILLSLR EIIREDEPYS
910 920 930 940 950
RVTLLEYLKQ LHPHEWDCFV KDTKILADET SQLNGEPEKN EKDAQKSKID
960 970 980 990 1000
DLPFYCIGFK SAAPEYTLRT RIWSSLRSQT LYRTISGFMN YSRAIKLLYR
1010 1020 1030 1040 1050
VENPEVVQMF GGNSEKLERE LERMARRKFK ICVSMQRYAK FNKEERENTE
1060 1070 1080 1090 1100
FLLRAYPDLQ IAYLDEEPPA NEGEEPRLYS ALIDGHCELL DNGMRKPKFR
1110 1120 1130 1140 1150
IQLSGNPILG DGKSDNQNHS IIFYRGEYIQ VIDANQDNYL EECLKIRSVL
1160 1170 1180 1190 1200
AEFEELTTDN VSPYTPGIAT EAETPVAILG AREYIFSENV GVLGDVAASK
1210 1220 1230 1240 1250
EQTFGTLFAR TLAQIGGKLH YGHPDFLNGI FMTTRGGISK AQKGLHLNED
1260 1270 1280 1290 1300
IYAGMTALCR GGRIKHCEYF QCGKGRDLGF GSILNFTTKI GTGMGEQMLS
1310 1320 1330 1340 1350
REYYYLGTQL PLDRFLSFYY AHPGFHLNNM FIMLSVQMFM IVLINLGALK
1360 1370 1380 1390 1400
HETITCRYNS NLPITDPLRP TYCADLTPII AWVNRCVVSI FIVFFISFVP
1410 1420 1430 1440 1450
LAVQELTERG LWRMATRLAK HFGSFSFMFE VFVCQIYANA VHQNLSFGGA
1460 1470 1480 1490 1500
RYIGTGRGFA TARIPFGVLY SRFAGPSIYA GSRLLLMLLF ATSTVWTPAL
1510 1520 1530 1540 1550
IWFWVSLLAL CISPFLFNPH QFAWHDFFID YRDYIRWLSR GNSRSHASSW
1560 1570 1580 1590 1600
IAFCRLSRTR LTGYKRKLLG VPSEKGSGDV PRAKFTNIFF SEIIAPLVQV
1610 1620 1630 1640 1650
AVTLVPYLYI NSRTGISNDN ERASNAVVRI AIVAFGPIGV NAGVSGMFFG
1660 1670 1680 1690 1700
MACCMGPIFG MCCKKFGAVL AAIAHAIAVI ILLVIFEVMF FLESWSWPRM
1710 1720 1730 1740 1750
VLGMISAAAI QRFIYKLIIS LALTREFKHD QSNIAWWTGK WYNMGWHSLS
1760 1770 1780 1790 1800
QPGREFLCKI TELGYFSADF VLGHILLFVM LPALCIPYVD KFHSVILFWL
1810 1820 1830 1840 1850
RPSRQIRPPI YSLKQSKLRK RRVVRFAILY FTMLVLFLIL LIAPLVARDE
1860 1870 1880 1890
GISVNLNIMS LMQPLDTDNN DTISSYTGNG LPVGYSAWTP SAASASA
Length:1,897
Mass (Da):216,975
Last modified:March 6, 2007 - v1
Checksum:i083DB5C85CF51E15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270115 Genomic DNA. Translation: CAK47999.1.
AY533027 Genomic DNA. Translation: AAS37661.1.
RefSeqiXP_001390977.1. XM_001390940.2.

Genome annotation databases

EnsemblFungiiCADANGAT00005160; CADANGAP00005055; CADANGAG00005160.
GeneIDi4981154.
KEGGiang:ANI_1_188054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270115 Genomic DNA. Translation: CAK47999.1.
AY533027 Genomic DNA. Translation: AAS37661.1.
RefSeqiXP_001390977.1. XM_001390940.2.

3D structure databases

ProteinModelPortaliA2QLK4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00362. Anidulafungin.
DB00520. Caspofungin.
DB01141. Micafungin.

Protein family/group databases

CAZyiGT48. Glycosyltransferase Family 48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANGAT00005160; CADANGAP00005055; CADANGAG00005160.
GeneIDi4981154.
KEGGiang:ANI_1_188054.

Organism-specific databases

EuPathDBiFungiDB:An06g01550.

Phylogenomic databases

HOGENOMiHOG000216604.
KOiK00706.
OrthoDBiEOG092C025F.

Family and domain databases

InterProiIPR026899. FKS1-like_dom1.
IPR003440. Glyco_trans_48.
[Graphical view]
PfamiPF14288. FKS1_dom1. 1 hit.
PF02364. Glucan_synthase. 1 hit.
[Graphical view]
SMARTiSM01205. FKS1_dom1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKS1_ASPNC
AccessioniPrimary (citable) accession number: A2QLK4
Secondary accession number(s): Q5DRK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.