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A2QLK4 (FKS1_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1,3-beta-glucan synthase component FKS1
EC=2.4.1.34
Alternative name(s):
1,3-beta-D-glucan-UDP glucosyltransferase
Gene names
Name:fksA
Synonyms:fks1
ORF Names:An06g01550
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length1897 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic subunit of the 1,3-beta-glucan synthase. Synthesizes 1,3-beta-glucan, a major structural component of the cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling By similarity. UniProtKB P38631

Catalytic activity

UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1).

Subunit structure

Component of the 1,3-beta-glucan synthase, composed of at least catalytic subunit fksA, and a regulatory subunit By similarity. UniProtKB P38631

Subcellular location

Mitochondrion. Cell membrane; Multi-pass membrane protein By similarity UniProtKB P38631.

Sequence similarities

Belongs to the glycosyltransferase 48 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189718971,3-beta-glucan synthase component FKS1
PRO_0000322581

Regions

Transmembrane487 – 50721Helical; Potential
Transmembrane525 – 54521Helical; Potential
Transmembrane564 – 58421Helical; Potential
Transmembrane591 – 61121Helical; Potential
Transmembrane655 – 67521Helical; Potential
Transmembrane707 – 72721Helical; Potential
Transmembrane728 – 74821Helical; Potential
Transmembrane1329 – 134921Helical; Potential
Transmembrane1386 – 140621Helical; Potential
Transmembrane1473 – 149321Helical; Potential
Transmembrane1497 – 151721Helical; Potential
Transmembrane1588 – 160821Helical; Potential
Transmembrane1630 – 165021Helical; Potential
Transmembrane1666 – 168621Helical; Potential
Transmembrane1701 – 172121Helical; Potential
Transmembrane1766 – 178621Helical; Potential
Transmembrane1826 – 184621Helical; Potential
Compositional bias4 – 7875Tyr-rich

Sequences

Sequence LengthMass (Da)Tools
A2QLK4 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 083DB5C85CF51E15

FASTA1,897216,975
        10         20         30         40         50         60 
MSGYPAGHYE DGYGHQEHGG DAYYQDEHGQ AYYDPNDYGD SYYDRGNYYN AEGGQAYGQE 

        70         80         90        100        110        120 
GGYYDAGHQD DYYGDQYYDQ GNGAPRGRRR GDSEEDSETF SDFTMRSETA RAADMDYYGR 

       130        140        150        160        170        180 
GDERYNSYAD SQYAGRGYNG YRPPSSQVSY GANRSSGAST PVYGMDYGSA LPGGPRSREP 

       190        200        210        220        230        240 
YPAWASDGQV PVSKEEIEDI FIDLVNKFGF QRDSMRNMYD HLMTQLDSRA SRMTPNQALL 

       250        260        270        280        290        300 
SLHADYIGGD NANYRRWYFA AHLDLDDAVG FANMKLGKAD RKTRKARKAA KAAAQQNPEN 

       310        320        330        340        350        360 
VEENLEAMEG DNSLEAAVYR WKSRMNRMSP HDRVRQLALY MLCWGEANQV RYMPECICFI 

       370        380        390        400        410        420 
FKCADDYYSS PECQSRVEPV EEFTYLNEII TPLYQFCRDQ GYEILDGKYV RRERDHEKII 

       430        440        450        460        470        480 
GYDDMNQLFW YPEGIERISF EDKTRLVDVP PAERWTKLKD VDWKKAFFKT YRETRSWFHM 

       490        500        510        520        530        540 
ITNFNRIWVI HLGAFWFFTA YNAPTLYTKN YQQQLDNKPA GSKYWSAVGF GGALVGLIQI 

       550        560        570        580        590        600 
LATLCEWMYV PRRWAGAQHL SKRLMFLIAV FIVNLAPGVV VFGFNNVLSE TICLIIGIVH 

       610        620        630        640        650        660 
FFIALATFFF FSVMPLGGLF GSYLKKHGRQ YVASQTFTAS YPRLNGNDMW MSYGLWICVF 

       670        680        690        700        710        720 
GAKLVESYFF LTLSLKDPMR ILSPMRIHQC AGVTYIPNSL CHAQPQILLG LMMFMDLTLF 

       730        740        750        760        770        780 
FLDSYLWYVI CNTIFSVARS FYLGVSIWSP WRNIFSRLPK RIYSKVLATT DMEIKYKPKV 

       790        800        810        820        830        840 
LISQVWNAII ISMYREHLLA IDHVQKLLYH QVPSEQEGKR TLRAPTFFVS QEDQSFKTEF 

       850        860        870        880        890        900 
FPAGSEAERR ISFFAQSVAT PMPEPLPVDN MPTFTVLIPH YGEKILLSLR EIIREDEPYS 

       910        920        930        940        950        960 
RVTLLEYLKQ LHPHEWDCFV KDTKILADET SQLNGEPEKN EKDAQKSKID DLPFYCIGFK 

       970        980        990       1000       1010       1020 
SAAPEYTLRT RIWSSLRSQT LYRTISGFMN YSRAIKLLYR VENPEVVQMF GGNSEKLERE 

      1030       1040       1050       1060       1070       1080 
LERMARRKFK ICVSMQRYAK FNKEERENTE FLLRAYPDLQ IAYLDEEPPA NEGEEPRLYS 

      1090       1100       1110       1120       1130       1140 
ALIDGHCELL DNGMRKPKFR IQLSGNPILG DGKSDNQNHS IIFYRGEYIQ VIDANQDNYL 

      1150       1160       1170       1180       1190       1200 
EECLKIRSVL AEFEELTTDN VSPYTPGIAT EAETPVAILG AREYIFSENV GVLGDVAASK 

      1210       1220       1230       1240       1250       1260 
EQTFGTLFAR TLAQIGGKLH YGHPDFLNGI FMTTRGGISK AQKGLHLNED IYAGMTALCR 

      1270       1280       1290       1300       1310       1320 
GGRIKHCEYF QCGKGRDLGF GSILNFTTKI GTGMGEQMLS REYYYLGTQL PLDRFLSFYY 

      1330       1340       1350       1360       1370       1380 
AHPGFHLNNM FIMLSVQMFM IVLINLGALK HETITCRYNS NLPITDPLRP TYCADLTPII 

      1390       1400       1410       1420       1430       1440 
AWVNRCVVSI FIVFFISFVP LAVQELTERG LWRMATRLAK HFGSFSFMFE VFVCQIYANA 

      1450       1460       1470       1480       1490       1500 
VHQNLSFGGA RYIGTGRGFA TARIPFGVLY SRFAGPSIYA GSRLLLMLLF ATSTVWTPAL 

      1510       1520       1530       1540       1550       1560 
IWFWVSLLAL CISPFLFNPH QFAWHDFFID YRDYIRWLSR GNSRSHASSW IAFCRLSRTR 

      1570       1580       1590       1600       1610       1620 
LTGYKRKLLG VPSEKGSGDV PRAKFTNIFF SEIIAPLVQV AVTLVPYLYI NSRTGISNDN 

      1630       1640       1650       1660       1670       1680 
ERASNAVVRI AIVAFGPIGV NAGVSGMFFG MACCMGPIFG MCCKKFGAVL AAIAHAIAVI 

      1690       1700       1710       1720       1730       1740 
ILLVIFEVMF FLESWSWPRM VLGMISAAAI QRFIYKLIIS LALTREFKHD QSNIAWWTGK 

      1750       1760       1770       1780       1790       1800 
WYNMGWHSLS QPGREFLCKI TELGYFSADF VLGHILLFVM LPALCIPYVD KFHSVILFWL 

      1810       1820       1830       1840       1850       1860 
RPSRQIRPPI YSLKQSKLRK RRVVRFAILY FTMLVLFLIL LIAPLVARDE GISVNLNIMS 

      1870       1880       1890 
LMQPLDTDNN DTISSYTGNG LPVGYSAWTP SAASASA

« Hide

References

« Hide 'large scale' references
[1]"Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M. expand/collapse author list , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
Nat. Biotechnol. 25:221-231(2007) [PubMed: 17259976] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CBS 513.88 / FGSC A1513.
[2]"Expression of agsA, one of five 1,3-alpha-D-glucan synthase-encoding genes in Aspergillus niger, is induced in response to cell wall stress."
Damveld R.A., van Kuyk P.A., Arentshorst M., Klis F.M., van den Hondel C.A.M.J.J., Ram A.F.
Fungal Genet. Biol. 42:165-177(2005) [PubMed: 15670714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1133-1254.
Strain: ATCC 9089 / N402.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM270115 Genomic DNA. Translation: CAK47999.1.
AY533027 Genomic DNA. Translation: AAS37661.1.
RefSeqXP_001390977.1. XM_001390940.2.

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT48. Glycosyltransferase Family 48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005160; CADANGAP00005055; CADANGAG00005160.
GeneID4981154.
GenomeReviewsGene locus fksA in contig AM270985_GR.
KEGGang:ANI_1_188054.

Phylogenomic databases

GeneTreeEFGT00050000001535.
HOGENOMHBG332273.
OrthoDBEOG49PF6H.

Family and domain databases

InterProIPR003440. Glyco_trans_48.
[Graphical view]
KOK00706.
PfamPF02364. Glucan_synthase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKS1_ASPNC
AccessionPrimary (citable) accession number: A2QLK4
Secondary accession number(s): Q5DRK6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents